Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4420120..4420901 Replicon chromosome
Accession NZ_CP091544
Organism Salmonella enterica strain 1618

Toxin (Protein)


Gene name TacT2 Uniprot ID E8X9W8
Locus tag L4414_RS21710 Protein ID WP_000626099.1
Coordinates 4420120..4420611 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag L4414_RS21715 Protein ID WP_001110452.1
Coordinates 4420608..4420901 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L4414_RS21675 (4416115) 4416115..4416690 + 576 WP_001188509.1 transcriptional regulator -
L4414_RS21685 (4416961) 4416961..4417038 - 78 Protein_4248 helix-turn-helix domain-containing protein -
L4414_RS21690 (4417129) 4417129..4417461 - 333 WP_001165471.1 MerR family transcriptional regulator -
L4414_RS21695 (4417533) 4417533..4417910 + 378 WP_000916345.1 EthD family reductase -
L4414_RS21700 (4418943) 4418943..4419017 + 75 Protein_4251 porin family protein -
L4414_RS21705 (4419120) 4419120..4419872 + 753 WP_000842434.1 non-specific acid phosphatase -
L4414_RS21710 (4420120) 4420120..4420611 - 492 WP_000626099.1 GNAT family N-acetyltransferase Toxin
L4414_RS21715 (4420608) 4420608..4420901 - 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
L4414_RS21720 (4421218) 4421218..4421439 + 222 WP_001576552.1 hypothetical protein -
L4414_RS21725 (4421704) 4421704..4422579 + 876 WP_000921674.1 AraC family transcriptional regulator -
L4414_RS21730 (4422576) 4422576..4422863 + 288 WP_001269916.1 transcriptional regulator RtsB -
L4414_RS21735 (4422886) 4422886..4423101 + 216 WP_001595136.1 hypothetical protein -
L4414_RS21740 (4423109) 4423109..4423378 + 270 WP_010989096.1 hypothetical protein -
L4414_RS21745 (4423672) 4423672..4424577 - 906 WP_001268200.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17646.39 Da        Isoelectric Point: 6.8437

>T233644 WP_000626099.1 NZ_CP091544:c4420611-4420120 [Salmonella enterica]
MISTPEPLHAGHILTPFCCGVDSIDNWLEQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

>T233644 NZ_KR071788:c13820-13494 [Xanthomonas oryzae pv. oryzicola]
ATGATGCGGGGTGACTTTGTGACCATCGCCATGCAAGGCGACTTCGGAAAACCACGGCCCGCTCTGGTGATCCAGGCCGA
CCAGTTTGACGCACACACCACCGTGACGGTGCTGCCGGTGACAAGCACGCTCGTTGCTGCGCCGCTGCTGCGCATTACCG
TTCATCCAAGTACCGACAATGGTTTGCAGAAGCCGTCTCAGGTGATGGTGGACAAGGCCATGACCGTGAAGCGTGACAAG
GTAGGTCGAGCCTTTGGGCGCGTAGACGCTGATGCGTTGGTGGTAATTGAGCGCTGCCTGGCCGTGTTCTTGGGCATCGC
TAAGTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT233644 WP_001110452.1 NZ_CP091544:c4420901-4420608 [Salmonella enterica]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT233644 NZ_KR071788:c14035-13817 [Xanthomonas oryzae pv. oryzicola]
ATGGCACACGTCAATTCACGAGTTCAAAAGCACCGCGACGCCCTGCGCATGGCAGGGCTGCGTCCGGTGCAAATTTGGGT
GCCGGACACACGGCGGCCTGACTTCGCCGCGGAATGCCGCCGTCAGTGTCGTCTTGCTGCACAAGCGGACATGGCGGACA
CCGACATGCAGCGCTTCATGGATGAGGCGCTAGCAGACATGGATGGCTGGACGGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7AK7

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References