Detailed information of TA system TA233644

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 4420120..4420901
• Replicon: chromosome
• Accession: NZ_CP091544
• Organism: Salmonella enterica strain 1618

Toxin (Protein)

• Gene name: TacT2
• Uniprot ID: E8X9W8
• Locus tag: L4414_RS21710
• Protein ID: WP_000626099.1
• Coordinates: 4420120..4420611 (-)
• Length: 164 a.a.

Antitoxin (Protein)

• Gene name: TacA2
• Uniprot ID: B5R979
• Locus tag: L4414_RS21715
• Protein ID: WP_001110452.1
• Coordinates: 4420608..4420901 (-)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L4414_RS21675 (4416115)	4416115..4416690	+	576	WP_001188509.1	transcriptional regulator	-
L4414_RS21685 (4416961)	4416961..4417038	-	78	Protein_4248	helix-turn-helix domain-containing protein	-
L4414_RS21690 (4417129)	4417129..4417461	-	333	WP_001165471.1	MerR family transcriptional regulator	-
L4414_RS21695 (4417533)	4417533..4417910	+	378	WP_000916345.1	EthD family reductase	-
L4414_RS21700 (4418943)	4418943..4419017	+	75	Protein_4251	porin family protein	-
L4414_RS21705 (4419120)	4419120..4419872	+	753	WP_000842434.1	non-specific acid phosphatase	-
L4414_RS21710 (4420120)	4420120..4420611	-	492	WP_000626099.1	GNAT family N-acetyltransferase	Toxin
L4414_RS21715 (4420608)	4420608..4420901	-	294	WP_001110452.1	DUF1778 domain-containing protein	Antitoxin
L4414_RS21720 (4421218)	4421218..4421439	+	222	WP_001576552.1	hypothetical protein	-
L4414_RS21725 (4421704)	4421704..4422579	+	876	WP_000921674.1	AraC family transcriptional regulator	-
L4414_RS21730 (4422576)	4422576..4422863	+	288	WP_001269916.1	transcriptional regulator RtsB	-
L4414_RS21735 (4422886)	4422886..4423101	+	216	WP_001595136.1	hypothetical protein	-
L4414_RS21740 (4423109)	4423109..4423378	+	270	WP_010989096.1	hypothetical protein	-
L4414_RS21745 (4423672)	4423672..4424577	-	906	WP_001268200.1	YjiK family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (85-145)

Antitoxin

• Vibrio phage ICP1, Orf50 (14-88)

Sequences

Toxin

Protein

• Length: 164 a.a.
• Molecular weight: 17646.39 Da
• Isoelectric Point: 6.8437

>T233644 WP_000626099.1 NZ_CP091544:c4420611-4420120 [Salmonella enterica]
MISTPEPLHAGHILTPFCCGVDSIDNWLEQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Nucleotide

• Length: 492 bp

>T233644 NZ_KR071788:c13820-13494 [Xanthomonas oryzae pv. oryzicola]
ATGATGCGGGGTGACTTTGTGACCATCGCCATGCAAGGCGACTTCGGAAAACCACGGCCCGCTCTGGTGATCCAGGCCGA
CCAGTTTGACGCACACACCACCGTGACGGTGCTGCCGGTGACAAGCACGCTCGTTGCTGCGCCGCTGCTGCGCATTACCG
TTCATCCAAGTACCGACAATGGTTTGCAGAAGCCGTCTCAGGTGATGGTGGACAAGGCCATGACCGTGAAGCGTGACAAG
GTAGGTCGAGCCTTTGGGCGCGTAGACGCTGATGCGTTGGTGGTAATTGAGCGCTGCCTGGCCGTGTTCTTGGGCATCGC
TAAGTGA

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 10977.61 Da
• Isoelectric Point: 8.6141

>AT233644 WP_001110452.1 NZ_CP091544:c4420901-4420608 [Salmonella enterica]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Nucleotide

• Length: 294 bp

>AT233644 NZ_KR071788:c14035-13817 [Xanthomonas oryzae pv. oryzicola]
ATGGCACACGTCAATTCACGAGTTCAAAAGCACCGCGACGCCCTGCGCATGGCAGGGCTGCGTCCGGTGCAAATTTGGGT
GCCGGACACACGGCGGCCTGACTTCGCCGCGGAATGCCGCCGTCAGTGTCGTCTTGCTGCACAAGCGGACATGGCGGACA
CCGACATGCAGCGCTTCATGGATGAGGCGCTAGCAGACATGGATGGCTGGACGGAATGA

Structures

Toxin

• PDB: 7AK7

Antitoxin

• AlphaFold DB: A0A5I1DGA4