Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4290784..4291300 Replicon chromosome
Accession NZ_CP091544
Organism Salmonella enterica strain 1618

Toxin (Protein)


Gene name relE Uniprot ID C0Q7A9
Locus tag L4414_RS21035 Protein ID WP_000220578.1
Coordinates 4290784..4291068 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag L4414_RS21040 Protein ID WP_000212724.1
Coordinates 4291058..4291300 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L4414_RS21020 (4285996) 4285996..4287648 + 1653 WP_000155057.1 alpha,alpha-phosphotrehalase -
L4414_RS21025 (4288057) 4288057..4290195 + 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
L4414_RS21030 (4290316) 4290316..4290780 + 465 WP_001268859.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
L4414_RS21035 (4290784) 4290784..4291068 - 285 WP_000220578.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
L4414_RS21040 (4291058) 4291058..4291300 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
L4414_RS21045 (4291378) 4291378..4293291 - 1914 WP_001212137.1 BglG family transcription antiterminator -
L4414_RS21050 (4293308) 4293308..4294048 - 741 WP_000779263.1 KDGP aldolase family protein -
L4414_RS21055 (4294045) 4294045..4295163 - 1119 WP_001139182.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
L4414_RS21060 (4295147) 4295147..4296280 - 1134 WP_000459930.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10854.67 Da        Isoelectric Point: 10.0482

>T233643 WP_000220578.1 NZ_CP091544:c4291068-4290784 [Salmonella enterica]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT233643 WP_000212724.1 NZ_CP091544:c4291300-4291058 [Salmonella enterica]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E876

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References