Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 953378..954038 Replicon chromosome
Accession NZ_CP091544
Organism Salmonella enterica strain 1618

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag L4414_RS04680 Protein ID WP_000244756.1
Coordinates 953625..954038 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag L4414_RS04675 Protein ID WP_000351186.1
Coordinates 953378..953644 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L4414_RS04655 (949306) 949306..950739 - 1434 WP_001230141.1 6-phospho-beta-glucosidase BglA -
L4414_RS04660 (950898) 950898..951209 + 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
L4414_RS04665 (951373) 951373..952032 + 660 WP_000250289.1 hemolysin III family protein -
L4414_RS04670 (952148) 952148..953128 - 981 WP_000874172.1 tRNA-modifying protein YgfZ -
L4414_RS04675 (953378) 953378..953644 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
L4414_RS04680 (953625) 953625..954038 + 414 WP_000244756.1 protein YgfX Toxin
L4414_RS04685 (954091) 954091..954612 - 522 WP_001055885.1 flavodoxin FldB -
L4414_RS04690 (954725) 954725..955621 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
L4414_RS04695 (955645) 955645..956358 + 714 WP_000745625.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
L4414_RS04700 (956364) 956364..958097 + 1734 WP_000813394.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T233626 WP_000244756.1 NZ_CP091544:953625-954038 [Salmonella enterica]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

>T233626 NZ_HG999363:4770663-4771079 [Xanthomonas euroxanthea]
GTGATCCTGCTCGATACCAATGTCATCTCCGAGCTTTGGCGGCCTCAGCCCAACCCGAAGGTCGTTGCCTGGATCGATGC
GCAGGCTGTCGAGACACTGTTCCTGTCGGTGGTAACGGTGGCCGAATTGCGTTTTGGCATTGCCGTGATGCCCGAGGGCC
GCAAGCGATCCACGTTGCATGCACGGTTGGAAAGCGATGTATTGCCACTGTTCAATGGGCGCCTGCTGGCGTTTGATCTG
GACGCATCGCACGCATTCGCGACACTCGCATCGAAAGCCAGAGCCGCAGGACTCACACTCGGTCGCGCCGATGCCTACAT
CGCTGCAACGGCAGCCGCGCAAGGCCTGACCGTTGCCACTCGCGACACGGCACCGTTCGCGGCGATGGCGCTGGACGTCA
TTGACCCGTGGAGTTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT233626 WP_000351186.1 NZ_CP091544:953378-953644 [Salmonella enterica]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT233626 NZ_HG999363:4770412-4770666 [Xanthomonas euroxanthea]
ATGCCTTCTTTCACCGTCCGCAATATCCCCGATGAGGTGCATCGCGCGATCCGCGCGAGGGCCGCACTCCACGGCCGCAG
CACCGAGGCGGAGATCCGCGCAATCCTTGAATCAGCGGCCAAACCGGCAGACCGGGTCAAACTCGGCTCCCTGCTGGTGG
ACATTGGCCGCGACGCTGGCCTGACAGCAAAACAGGCCGACGCGTTCGACACCTTACGCGACAAGACCGCAATCAAGCCG
ATCAGCCTGAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References