Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4495235..4496016 Replicon chromosome
Accession NZ_CP091542
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain S58L2

Toxin (Protein)


Gene name TacT2 Uniprot ID E8X9W8
Locus tag L5Z53_RS22245 Protein ID WP_000626099.1
Coordinates 4495235..4495726 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag L5Z53_RS22250 Protein ID WP_001110452.1
Coordinates 4495723..4496016 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L5Z53_RS22205 (4490421) 4490421..4490663 - 243 WP_197603740.1 hypothetical protein -
L5Z53_RS22210 (4490660) 4490660..4491016 - 357 WP_033567083.1 hypothetical protein -
L5Z53_RS22215 (4491013) 4491013..4491885 - 873 WP_033567082.1 ParA family protein -
L5Z53_RS22220 (4492076) 4492076..4492153 - 78 Protein_4349 helix-turn-helix domain-containing protein -
L5Z53_RS22225 (4492244) 4492244..4492576 - 333 WP_001165471.1 MerR family transcriptional regulator -
L5Z53_RS22230 (4492648) 4492648..4493025 + 378 WP_000916345.1 EthD family reductase -
L5Z53_RS22235 (4494058) 4494058..4494132 + 75 Protein_4352 porin family protein -
L5Z53_RS22240 (4494235) 4494235..4494987 + 753 WP_000842434.1 non-specific acid phosphatase -
L5Z53_RS22245 (4495235) 4495235..4495726 - 492 WP_000626099.1 GNAT family N-acetyltransferase Toxin
L5Z53_RS22250 (4495723) 4495723..4496016 - 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
L5Z53_RS22255 (4496333) 4496333..4496554 + 222 WP_001576552.1 hypothetical protein -
L5Z53_RS22260 (4496819) 4496819..4497694 + 876 WP_000921674.1 AraC family transcriptional regulator -
L5Z53_RS22265 (4497691) 4497691..4497978 + 288 WP_001269916.1 transcriptional regulator RtsB -
L5Z53_RS22270 (4498001) 4498001..4498216 + 216 WP_001595136.1 hypothetical protein -
L5Z53_RS22275 (4498224) 4498224..4498493 + 270 WP_010989096.1 hypothetical protein -
L5Z53_RS22280 (4498787) 4498787..4499692 - 906 WP_001268200.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17646.39 Da        Isoelectric Point: 6.8437

>T233619 WP_000626099.1 NZ_CP091542:c4495726-4495235 [Salmonella enterica subsp. enterica serovar Typhimurium]
MISTPEPLHAGHILTPFCCGVDSIDNWLEQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

>T233619 NZ_HG995459:5696935-5697225 [Pseudomonas sp. PP3]
ATGGCCGAACAATTCACCCGTTTTGATGCCGCCGAGTTTCTCAAGACTCCGGAAGAAATGGCGGCTTATCTGGATGCCTG
TTTTGAAGAAGATGCCGGTGACGGCGTCCTGATTCGAGCGGCTCTCAACGACATCGCCAGAGCAAAGGGCATGACACAAA
TTGCCCGTGATGCCGGCTTGGGACGTGAGAGTCTATATAAAGCTCTGAGCAGCACTGGCAATCCGGAATTCGCGACTATC
ATGAAGGTTATGAAGGCGCTCGGTCTGCGTTTGCATGCCACTGTTGTCTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT233619 WP_001110452.1 NZ_CP091542:c4496016-4495723 [Salmonella enterica subsp. enterica serovar Typhimurium]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT233619 NZ_HG995459:5696629-5696931 [Pseudomonas sp. PP3]
ATGATCGACTTCAAACGATCCCAAATATTTGCCGATTGGCTCGGCTCACTGAGGGACACCCTTGGCAAGGCTCGCATCAT
TGCCAGACTCCGCGCTGCCGAACATGGAAACTTTGGTGACTGTGACTCCATTGGTGCAACGGTCTATGAAATGCGCGTGC
ATCATGGTCCCGGCTATCGGATCTATTTCACACGCAAAGGCGAAAGGGTTTATCTGCTGCTGGTAGGCGGAGACAAGTCG
ACTCAAAAAAGAGATATCAAACGTGCCATTCAAATGGCACAAAACATCGGTAATGAGGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7AK7

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References