Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4249318..4249834 Replicon chromosome
Accession NZ_CP091542
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain S58L2

Toxin (Protein)


Gene name relE Uniprot ID C0Q7A9
Locus tag L5Z53_RS20895 Protein ID WP_000220578.1
Coordinates 4249318..4249602 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag L5Z53_RS20900 Protein ID WP_000212724.1
Coordinates 4249592..4249834 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L5Z53_RS20880 (4244530) 4244530..4246182 + 1653 WP_000155057.1 alpha,alpha-phosphotrehalase -
L5Z53_RS20885 (4246591) 4246591..4248729 + 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
L5Z53_RS20890 (4248850) 4248850..4249314 + 465 WP_001268859.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
L5Z53_RS20895 (4249318) 4249318..4249602 - 285 WP_000220578.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
L5Z53_RS20900 (4249592) 4249592..4249834 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
L5Z53_RS20905 (4249912) 4249912..4251825 - 1914 WP_001212137.1 BglG family transcription antiterminator -
L5Z53_RS20910 (4251842) 4251842..4252582 - 741 WP_000779263.1 KDGP aldolase family protein -
L5Z53_RS20915 (4252579) 4252579..4253697 - 1119 WP_001139182.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
L5Z53_RS20920 (4253681) 4253681..4254814 - 1134 WP_000459930.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10854.67 Da        Isoelectric Point: 10.0482

>T233618 WP_000220578.1 NZ_CP091542:c4249602-4249318 [Salmonella enterica subsp. enterica serovar Typhimurium]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

>T233618 NZ_HG995459:5696629-5696931 [Pseudomonas sp. PP3]
ATGATCGACTTCAAACGATCCCAAATATTTGCCGATTGGCTCGGCTCACTGAGGGACACCCTTGGCAAGGCTCGCATCAT
TGCCAGACTCCGCGCTGCCGAACATGGAAACTTTGGTGACTGTGACTCCATTGGTGCAACGGTCTATGAAATGCGCGTGC
ATCATGGTCCCGGCTATCGGATCTATTTCACACGCAAAGGCGAAAGGGTTTATCTGCTGCTGGTAGGCGGAGACAAGTCG
ACTCAAAAAAGAGATATCAAACGTGCCATTCAAATGGCACAAAACATCGGTAATGAGGAGTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT233618 WP_000212724.1 NZ_CP091542:c4249834-4249592 [Salmonella enterica subsp. enterica serovar Typhimurium]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp

>AT233618 NZ_HG995459:5696935-5697225 [Pseudomonas sp. PP3]
ATGGCCGAACAATTCACCCGTTTTGATGCCGCCGAGTTTCTCAAGACTCCGGAAGAAATGGCGGCTTATCTGGATGCCTG
TTTTGAAGAAGATGCCGGTGACGGCGTCCTGATTCGAGCGGCTCTCAACGACATCGCCAGAGCAAAGGGCATGACACAAA
TTGCCCGTGATGCCGGCTTGGGACGTGAGAGTCTATATAAAGCTCTGAGCAGCACTGGCAATCCGGAATTCGCGACTATC
ATGAAGGTTATGAAGGCGCTCGGTCTGCGTTTGCATGCCACTGTTGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E876

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References