Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3536143..3536763 Replicon chromosome
Accession NZ_CP091542
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain S58L2

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag L5Z53_RS17620 Protein ID WP_001280991.1
Coordinates 3536545..3536763 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag L5Z53_RS17615 Protein ID WP_000344807.1
Coordinates 3536143..3536517 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L5Z53_RS17605 (3531282) 3531282..3532475 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
L5Z53_RS17610 (3532498) 3532498..3535647 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
L5Z53_RS17615 (3536143) 3536143..3536517 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
L5Z53_RS17620 (3536545) 3536545..3536763 + 219 WP_001280991.1 HHA domain-containing protein Toxin
L5Z53_RS17625 (3536942) 3536942..3537493 + 552 WP_001278792.1 maltose O-acetyltransferase -
L5Z53_RS17630 (3537610) 3537610..3538080 + 471 WP_000136181.1 YlaC family protein -
L5Z53_RS17635 (3538136) 3538136..3538276 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
L5Z53_RS17640 (3538282) 3538282..3538542 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
L5Z53_RS17645 (3538767) 3538767..3540317 + 1551 WP_000213139.1 EAL domain-containing protein -
L5Z53_RS17655 (3540548) 3540548..3540937 + 390 WP_000961285.1 MGMT family protein -
L5Z53_RS17660 (3540970) 3540970..3541539 - 570 WP_000779803.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T233613 WP_001280991.1 NZ_CP091542:3536545-3536763 [Salmonella enterica subsp. enterica serovar Typhimurium]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T233613 NZ_HG994851:c4918072-4917761 [Escherichia coli]
ATCCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGACCGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTGTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTACTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT233613 WP_000344807.1 NZ_CP091542:3536143-3536517 [Salmonella enterica subsp. enterica serovar Typhimurium]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT233613 NZ_HG994851:c4917760-4917470 [Escherichia coli]
ATGGATAAGGCACTTTTTGAGCGGTTGACTCACAGCATGGCCCAGATGAATGAAATTATTGAAGGAACGCGACAGCCTTC
GCGGACTTTTGAAGTTGATGCTATGAAAATCAAAGAAATACGCCGCGCTTCAGGGTTGTCACAATCTAAATTTGCCGATC
TTATTTCTGTAAGCGTAGACACGTTGCGTAACTGGGAGCAGGGGCGACGTTCACCGACCGGGCCTGCAAAGGCTTTGCTG
CGAGCGATTGCCAATGATCCGCAACATGTGCTGCAAGCACTTAACCGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References