Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 206521..207281 Replicon chromosome
Accession NZ_CP091542
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain S58L2

Toxin (Protein)


Gene name tacT Uniprot ID Q57IH1
Locus tag L5Z53_RS00970 Protein ID WP_000533909.1
Coordinates 206796..207281 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID M7RHS4
Locus tag L5Z53_RS00965 Protein ID WP_000965886.1
Coordinates 206521..206808 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L5Z53_RS00940 (201816) 201816..202118 + 303 WP_000605590.1 YsaB family lipoprotein -
L5Z53_RS00945 (202257) 202257..203168 + 912 WP_001168551.1 glycine--tRNA ligase subunit alpha -
L5Z53_RS00950 (203178) 203178..205247 + 2070 WP_001291736.1 glycine--tRNA ligase subunit beta -
L5Z53_RS00955 (205429) 205429..205704 + 276 Protein_189 IS3 family transposase -
L5Z53_RS00960 (205876) 205876..206343 + 468 WP_000702452.1 GNAT family N-acetyltransferase -
L5Z53_RS00965 (206521) 206521..206808 + 288 WP_000965886.1 DUF1778 domain-containing protein Antitoxin
L5Z53_RS00970 (206796) 206796..207281 + 486 WP_000533909.1 GNAT family N-acetyltransferase Toxin
L5Z53_RS00975 (207653) 207653..208192 - 540 WP_000047149.1 copper-binding periplasmic metallochaperone CueP -
L5Z53_RS00980 (208366) 208366..208578 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
L5Z53_RS00985 (208867) 208867..209157 - 291 WP_000455790.1 HTH-type transcriptional regulator -
L5Z53_RS00990 (209596) 209596..210306 + 711 WP_000190524.1 DUF3053 domain-containing protein -
L5Z53_RS00995 (210356) 210356..211330 - 975 WP_000804674.1 glyoxylate/hydroxypyruvate reductase GhrB -
L5Z53_RS01000 (211549) 211549..212211 - 663 WP_000747548.1 OmpA family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(5-94)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17703.41 Da        Isoelectric Point: 9.8719

>T233596 WP_000533909.1 NZ_CP091542:206796-207281 [Salmonella enterica subsp. enterica serovar Typhimurium]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

>T233596 NZ_HG994851:1929948-1930202 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAAATTATCAAAGATACACGCAGAACACCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GCTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10950.60 Da        Isoelectric Point: 4.6811

>AT233596 WP_000965886.1 NZ_CP091542:206521-206808 [Salmonella enterica subsp. enterica serovar Typhimurium]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp

>AT233596 NZ_HG994851:1929700-1929951 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7F36
PDB 7AK8
PDB 5FVJ

Antitoxin

Source ID Structure
PDB 7AK8
AlphaFold DB A0A3V2JDX2

References