233595

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 88154..89777 Replicon plasmid pMCR_S46L1
Accession NZ_CP091541
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain S46L1

Toxin (Protein)


Gene name hipA Uniprot ID H9TH67
Locus tag L5Z03_RS25065 Protein ID WP_000088046.1
Coordinates 88452..89777 (+) Length 442 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A5Z6V2D1
Locus tag L5Z03_RS25060 Protein ID WP_024136327.1
Coordinates 88154..88447 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L5Z03_RS25030 (L5Z03_24990) 84026..85267 + 1242 WP_001053338.1 VWA domain-containing protein -
L5Z03_RS25035 85358..85489 + 132 WP_000374059.1 hypothetical protein -
L5Z03_RS25040 (L5Z03_24995) 85830..86111 - 282 WP_000077926.1 hypothetical protein -
L5Z03_RS25045 (L5Z03_25000) 86161..86352 - 192 WP_000398480.1 hypothetical protein -
L5Z03_RS25050 (L5Z03_25005) 86444..86785 - 342 WP_001151575.1 hypothetical protein -
L5Z03_RS25055 (L5Z03_25010) 87158..87550 + 393 WP_000341066.1 hypothetical protein -
L5Z03_RS25060 (L5Z03_25015) 88154..88447 + 294 WP_024136327.1 helix-turn-helix transcriptional regulator Antitoxin
L5Z03_RS25065 (L5Z03_25020) 88452..89777 + 1326 WP_000088046.1 type II toxin-antitoxin system HipA family toxin Toxin
L5Z03_RS25070 (L5Z03_25025) 89838..90044 + 207 WP_000134171.1 hypothetical protein -
L5Z03_RS25075 (L5Z03_25030) 90146..90556 + 411 WP_000985911.1 hypothetical protein -
L5Z03_RS25080 (L5Z03_25035) 90569..91384 + 816 WP_001572439.1 HNH endonuclease signature motif containing protein -
L5Z03_RS25085 (L5Z03_25040) 91638..92063 + 426 WP_001043843.1 hypothetical protein -
L5Z03_RS25090 (L5Z03_25045) 92517..92753 + 237 Protein_90 type I restriction-modification system subunit M N-terminal domain-containing protein -
L5Z03_RS25095 (L5Z03_25050) 92808..93107 + 300 WP_001572440.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid mcr-1.1 / sul1 / qacE / ARR-3 / catB3 / blaOXA-1 / aac(6')-Ib-cr / aac(3)-IVa / aph(4)-Ia / sul2 - 1..149407 149407


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(9-108)

Antitoxin

Cro/C1-type helix-turn-helix domain

(21-69)


Sequences

Toxin        


Download         Length: 442 a.a.        Molecular weight: 50249.20 Da        Isoelectric Point: 6.1927

>T233595 WP_000088046.1 NZ_CP091541:88452-89777 [Salmonella enterica subsp. enterica serovar Typhimurium]
MSRKQQRLVIWMNGIKVGYWEKSKGVDSLEYLPEWVADEQGRPLSLSLPFTPGNQVWRGNVVRDYFDNLLPDSEGIRRRL
AMRYKADSLEPFDLLTELGKDCVGAIQLLHDGDEPTDLYSVKYHPLTESEIAATLRNTTETLLPGRPEDNDDLRLSIAGA
QEKTALLWHEDRWCMPEGNTPTTHIFKLPLGLVGNMKADMSSSVENEWLCSVLLGQYGLPVARTQIAHFEDQKALVVERF
DRKWSGDGQWIIRLPQEDMCQALGVSPLRKYQADGGPGISEIMEVLSNSDRAERDKAQFFMTQIIFWMMAATDGHAKNFS
ISIGPQGRYHLTPNYDVLSAWPVIGHGNNQISWQKCKLAMAVRGSSNYYQIYRIQRRHWIRHGEITGLSKQQTEAMIEEI
IARTPGVIERVSGLLPDQFPQQLAESIFDGMRQQCRRLAEK

Download         Length: 1326 bp

>T233595 NZ_HG994851:1929700-1929951 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10946.35 Da        Isoelectric Point: 10.0925

>AT233595 WP_024136327.1 NZ_CP091541:88154-88447 [Salmonella enterica subsp. enterica serovar Typhimurium]
INNDYPLNTLNQLRPLLIGFRKANGLTQKDLSERLGVTQQTYSRLEANPASASIERLFKVFSILGVKISFSSATTSSERK
QTEEMLKSNSPARQEDW

Download         Length: 294 bp

>AT233595 NZ_HG994851:1929948-1930202 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAAATTATCAAAGATACACGCAGAACACCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GCTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3T0VBU1

Antitoxin

Source ID Structure
AlphaFold DB A0A5Z6V2D1

References