Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
| Location | 4495363..4496144 | Replicon | chromosome |
| Accession | NZ_CP091540 | ||
| Organism | Salmonella enterica subsp. enterica serovar Typhimurium strain S46L1 | ||
Toxin (Protein)
| Gene name | TacT2 | Uniprot ID | E8X9W8 |
| Locus tag | L5Z03_RS22245 | Protein ID | WP_000626099.1 |
| Coordinates | 4495363..4495854 (-) | Length | 164 a.a. |
Antitoxin (Protein)
| Gene name | TacA2 | Uniprot ID | B5R979 |
| Locus tag | L5Z03_RS22250 | Protein ID | WP_001110452.1 |
| Coordinates | 4495851..4496144 (-) | Length | 98 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| L5Z03_RS22205 (4490549) | 4490549..4490791 | - | 243 | WP_197603740.1 | hypothetical protein | - |
| L5Z03_RS22210 (4490788) | 4490788..4491144 | - | 357 | WP_033567083.1 | hypothetical protein | - |
| L5Z03_RS22215 (4491141) | 4491141..4492013 | - | 873 | WP_033567082.1 | ParA family protein | - |
| L5Z03_RS22220 (4492204) | 4492204..4492281 | - | 78 | Protein_4350 | helix-turn-helix domain-containing protein | - |
| L5Z03_RS22225 (4492372) | 4492372..4492704 | - | 333 | WP_001165471.1 | MerR family transcriptional regulator | - |
| L5Z03_RS22230 (4492776) | 4492776..4493153 | + | 378 | WP_000916345.1 | EthD family reductase | - |
| L5Z03_RS22235 (4494186) | 4494186..4494260 | + | 75 | Protein_4353 | porin family protein | - |
| L5Z03_RS22240 (4494363) | 4494363..4495115 | + | 753 | WP_000842434.1 | non-specific acid phosphatase | - |
| L5Z03_RS22245 (4495363) | 4495363..4495854 | - | 492 | WP_000626099.1 | GNAT family N-acetyltransferase | Toxin |
| L5Z03_RS22250 (4495851) | 4495851..4496144 | - | 294 | WP_001110452.1 | DUF1778 domain-containing protein | Antitoxin |
| L5Z03_RS22255 (4496461) | 4496461..4496682 | + | 222 | WP_001576552.1 | hypothetical protein | - |
| L5Z03_RS22260 (4496947) | 4496947..4497822 | + | 876 | WP_000921674.1 | AraC family transcriptional regulator | - |
| L5Z03_RS22265 (4497819) | 4497819..4498106 | + | 288 | WP_001269916.1 | transcriptional regulator RtsB | - |
| L5Z03_RS22270 (4498129) | 4498129..4498344 | + | 216 | WP_001595136.1 | hypothetical protein | - |
| L5Z03_RS22275 (4498352) | 4498352..4498621 | + | 270 | WP_010989096.1 | hypothetical protein | - |
| L5Z03_RS22280 (4498915) | 4498915..4499820 | - | 906 | WP_001268200.1 | YjiK family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 164 a.a. Molecular weight: 17646.39 Da Isoelectric Point: 6.8437
>T233592 WP_000626099.1 NZ_CP091540:c4495854-4495363 [Salmonella enterica subsp. enterica serovar Typhimurium]
MISTPEPLHAGHILTPFCCGVDSIDNWLEQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV
MISTPEPLHAGHILTPFCCGVDSIDNWLEQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV
Download Length: 492 bp
>T233592 NZ_HG994851:c830857-830483 [Escherichia coli]
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGAGCTGCCCGTCTCCCGTCACCATCTGGCAGACTCTGCTCTC
CCGACTACTGGGCCAGCATTACGGCCTTACACTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACTTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGCATCCGGAGAAACGATGA
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGAGCTGCCCGTCTCCCGTCACCATCTGGCAGACTCTGCTCTC
CCGACTACTGGGCCAGCATTACGGCCTTACACTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACTTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGCATCCGGAGAAACGATGA
Antitoxin
Download Length: 98 a.a. Molecular weight: 10977.61 Da Isoelectric Point: 8.6141
>AT233592 WP_001110452.1 NZ_CP091540:c4496144-4495851 [Salmonella enterica subsp. enterica serovar Typhimurium]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK
Download Length: 294 bp
>AT233592 NZ_HG994851:c831315-830947 [Escherichia coli]
GTGTCAGACGCACTCTCCGGGACAATGCTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGTCTGACCTGCAAAGCTGACACTCTCGGTAGCGG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA
GTGTCAGACGCACTCTCCGGGACAATGCTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGTCTGACCTGCAAAGCTGACACTCTCGGTAGCGG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|