Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4495363..4496144 Replicon chromosome
Accession NZ_CP091540
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain S46L1

Toxin (Protein)


Gene name TacT2 Uniprot ID E8X9W8
Locus tag L5Z03_RS22245 Protein ID WP_000626099.1
Coordinates 4495363..4495854 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag L5Z03_RS22250 Protein ID WP_001110452.1
Coordinates 4495851..4496144 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L5Z03_RS22205 (4490549) 4490549..4490791 - 243 WP_197603740.1 hypothetical protein -
L5Z03_RS22210 (4490788) 4490788..4491144 - 357 WP_033567083.1 hypothetical protein -
L5Z03_RS22215 (4491141) 4491141..4492013 - 873 WP_033567082.1 ParA family protein -
L5Z03_RS22220 (4492204) 4492204..4492281 - 78 Protein_4350 helix-turn-helix domain-containing protein -
L5Z03_RS22225 (4492372) 4492372..4492704 - 333 WP_001165471.1 MerR family transcriptional regulator -
L5Z03_RS22230 (4492776) 4492776..4493153 + 378 WP_000916345.1 EthD family reductase -
L5Z03_RS22235 (4494186) 4494186..4494260 + 75 Protein_4353 porin family protein -
L5Z03_RS22240 (4494363) 4494363..4495115 + 753 WP_000842434.1 non-specific acid phosphatase -
L5Z03_RS22245 (4495363) 4495363..4495854 - 492 WP_000626099.1 GNAT family N-acetyltransferase Toxin
L5Z03_RS22250 (4495851) 4495851..4496144 - 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
L5Z03_RS22255 (4496461) 4496461..4496682 + 222 WP_001576552.1 hypothetical protein -
L5Z03_RS22260 (4496947) 4496947..4497822 + 876 WP_000921674.1 AraC family transcriptional regulator -
L5Z03_RS22265 (4497819) 4497819..4498106 + 288 WP_001269916.1 transcriptional regulator RtsB -
L5Z03_RS22270 (4498129) 4498129..4498344 + 216 WP_001595136.1 hypothetical protein -
L5Z03_RS22275 (4498352) 4498352..4498621 + 270 WP_010989096.1 hypothetical protein -
L5Z03_RS22280 (4498915) 4498915..4499820 - 906 WP_001268200.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17646.39 Da        Isoelectric Point: 6.8437

>T233592 WP_000626099.1 NZ_CP091540:c4495854-4495363 [Salmonella enterica subsp. enterica serovar Typhimurium]
MISTPEPLHAGHILTPFCCGVDSIDNWLEQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

>T233592 NZ_HG994851:c830857-830483 [Escherichia coli]
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGAGCTGCCCGTCTCCCGTCACCATCTGGCAGACTCTGCTCTC
CCGACTACTGGGCCAGCATTACGGCCTTACACTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACTTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGCATCCGGAGAAACGATGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT233592 WP_001110452.1 NZ_CP091540:c4496144-4495851 [Salmonella enterica subsp. enterica serovar Typhimurium]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT233592 NZ_HG994851:c831315-830947 [Escherichia coli]
GTGTCAGACGCACTCTCCGGGACAATGCTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGTCTGACCTGCAAAGCTGACACTCTCGGTAGCGG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7AK7

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References