Detailed information of TA system TA233591

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 4249446..4249962
• Replicon: chromosome
• Accession: NZ_CP091540
• Organism: Salmonella enterica subsp. enterica serovar Typhimurium strain S46L1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: C0Q7A9
• Locus tag: L5Z03_RS20890
• Protein ID: WP_000220578.1
• Coordinates: 4249446..4249730 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: V7ISI8
• Locus tag: L5Z03_RS20895
• Protein ID: WP_000212724.1
• Coordinates: 4249720..4249962 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L5Z03_RS20875 (4244658)	4244658..4246310	+	1653	WP_000155057.1	alpha,alpha-phosphotrehalase	-
L5Z03_RS20880 (4246719)	4246719..4248857	+	2139	WP_000187818.1	anaerobic ribonucleoside-triphosphate reductase	-
L5Z03_RS20885 (4248978)	4248978..4249442	+	465	WP_001268859.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
L5Z03_RS20890 (4249446)	4249446..4249730	-	285	WP_000220578.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
L5Z03_RS20895 (4249720)	4249720..4249962	-	243	WP_000212724.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
L5Z03_RS20900 (4250040)	4250040..4251953	-	1914	WP_001212137.1	BglG family transcription antiterminator	-
L5Z03_RS20905 (4251970)	4251970..4252710	-	741	WP_000779263.1	KDGP aldolase family protein	-
L5Z03_RS20910 (4252707)	4252707..4253825	-	1119	WP_001139182.1	DgaE family pyridoxal phosphate-dependent ammonia lyase	-
L5Z03_RS20915 (4253809)	4253809..4254942	-	1134	WP_000459930.1	amidohydrolase/deacetylase family metallohydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-83)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-80)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 10854.67 Da
• Isoelectric Point: 10.0482

>T233591 WP_000220578.1 NZ_CP091540:c4249730-4249446 [Salmonella enterica subsp. enterica serovar Typhimurium]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Nucleotide

• Length: 285 bp

>T233591 NZ_HG994851:c609049-608585 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGATGCTTTAGTTGC
CGAAGTCGAGGCATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCTGCCACAAAGTTATTGGCGGTGGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGCTATCGTCTCTTCTTTCGTTACAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACGCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGTAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAGCCATTGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8961.34 Da
• Isoelectric Point: 5.0651

>AT233591 WP_000212724.1 NZ_CP091540:c4249962-4249720 [Salmonella enterica subsp. enterica serovar Typhimurium]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Nucleotide

• Length: 243 bp

>AT233591 NZ_HG994851:c609384-609049 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTAACGCTGTACTGACCACTGAATCAAAGGTCACTATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCTGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCGACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGACGATGAGAT
TGGCGACGACGAATAA

Structures

Toxin

• AlphaFold DB: A0A3Z1E876

Antitoxin

• AlphaFold DB: A0A5H5JRI5