Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3536271..3536891 Replicon chromosome
Accession NZ_CP091540
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain S46L1

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag L5Z03_RS17615 Protein ID WP_001280991.1
Coordinates 3536673..3536891 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag L5Z03_RS17610 Protein ID WP_000344807.1
Coordinates 3536271..3536645 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L5Z03_RS17600 (3531410) 3531410..3532603 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
L5Z03_RS17605 (3532626) 3532626..3535775 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
L5Z03_RS17610 (3536271) 3536271..3536645 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
L5Z03_RS17615 (3536673) 3536673..3536891 + 219 WP_001280991.1 HHA domain-containing protein Toxin
L5Z03_RS17620 (3537070) 3537070..3537621 + 552 WP_001278792.1 maltose O-acetyltransferase -
L5Z03_RS17625 (3537738) 3537738..3538208 + 471 WP_000136181.1 YlaC family protein -
L5Z03_RS17630 (3538264) 3538264..3538404 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
L5Z03_RS17635 (3538410) 3538410..3538670 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
L5Z03_RS17640 (3538895) 3538895..3540445 + 1551 WP_000213139.1 EAL domain-containing protein -
L5Z03_RS17650 (3540676) 3540676..3541065 + 390 WP_000961285.1 MGMT family protein -
L5Z03_RS17655 (3541098) 3541098..3541667 - 570 WP_000779803.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T233586 WP_001280991.1 NZ_CP091540:3536673-3536891 [Salmonella enterica subsp. enterica serovar Typhimurium]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T233586 NZ_HG994850:4361546-4361887 [Escherichia coli]
ATGACTGACACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGCTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACTGCGGTAGATGTCAAAGTAATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGCCGAGAGCGAA
CTGATGCAGTCGCTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAGGCAGGTGCAGGAGTTTATTGGGGTGATTGC
GGGTAAACAGAAAGTCGCCTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT233586 WP_000344807.1 NZ_CP091540:3536271-3536645 [Salmonella enterica subsp. enterica serovar Typhimurium]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT233586 NZ_HG994850:c4361551-4361475 [Escherichia coli]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References