Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 838076..838736 Replicon chromosome
Accession NZ_CP091540
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain S46L1

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag L5Z03_RS04035 Protein ID WP_000244756.1
Coordinates 838323..838736 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag L5Z03_RS04030 Protein ID WP_000351186.1
Coordinates 838076..838342 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L5Z03_RS04010 (834004) 834004..835437 - 1434 WP_001230141.1 6-phospho-beta-glucosidase BglA -
L5Z03_RS04015 (835596) 835596..835907 + 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
L5Z03_RS04020 (836071) 836071..836730 + 660 WP_000250289.1 hemolysin III family protein -
L5Z03_RS04025 (836846) 836846..837826 - 981 WP_000874172.1 tRNA-modifying protein YgfZ -
L5Z03_RS04030 (838076) 838076..838342 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
L5Z03_RS04035 (838323) 838323..838736 + 414 WP_000244756.1 protein YgfX Toxin
L5Z03_RS04040 (838789) 838789..839310 - 522 WP_001055885.1 flavodoxin FldB -
L5Z03_RS04045 (839423) 839423..840319 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
L5Z03_RS04050 (840343) 840343..841056 + 714 WP_000745625.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
L5Z03_RS04055 (841062) 841062..842795 + 1734 WP_000813394.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T233572 WP_000244756.1 NZ_CP091540:838323-838736 [Salmonella enterica subsp. enterica serovar Typhimurium]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

>T233572 NZ_HG994850:1950304-1950558 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAAATTATCAAAGATACACGCAGAACACCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GCTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT233572 WP_000351186.1 NZ_CP091540:838076-838342 [Salmonella enterica subsp. enterica serovar Typhimurium]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT233572 NZ_HG994850:1950056-1950307 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References