Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3688636..3689254 Replicon chromosome
Accession NZ_CP091534
Organism Escherichia coli strain 537-20

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag L6D13_RS17950 Protein ID WP_001291435.1
Coordinates 3689036..3689254 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag L6D13_RS17945 Protein ID WP_000344800.1
Coordinates 3688636..3689010 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L6D13_RS17935 (3683725) 3683725..3684918 + 1194 WP_062872730.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
L6D13_RS17940 (3684941) 3684941..3688090 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
L6D13_RS17945 (3688636) 3688636..3689010 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
L6D13_RS17950 (3689036) 3689036..3689254 + 219 WP_001291435.1 HHA domain-containing protein Toxin
L6D13_RS17955 (3689426) 3689426..3689977 + 552 WP_000102568.1 maltose O-acetyltransferase -
L6D13_RS17960 (3690093) 3690093..3690563 + 471 WP_000136192.1 YlaC family protein -
L6D13_RS17965 (3690727) 3690727..3692277 + 1551 WP_001299455.1 cyclic-guanylate-specific phosphodiesterase PdeB -
L6D13_RS17970 (3692319) 3692319..3692672 - 354 WP_000878140.1 DUF1428 domain-containing protein -
L6D13_RS17980 (3693051) 3693051..3693362 + 312 WP_000409911.1 MGMT family protein -
L6D13_RS17985 (3693393) 3693393..3693965 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T233558 WP_001291435.1 NZ_CP091534:3689036-3689254 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T233558 NZ_HG992743:525720-526049 [Vibrio sp. B1ASS3]
ATGTACATTCCAGATAAAGGTGACATTGTTACTCTCGATTTCGATTCTAGCGCTGGAAAAGAGATCATGAAACGCCGTCC
TGCTTTTGTGATCTCTCGAAAAATGTTTAATGAGCATACTGGATTTGCTGTAGTGGCTCCAATTACTAGTACGATTAGAG
GGATGAAGTTAGAAGTGGTTCTTCCCGAATCATTATCTACTCAAGGTGCCGTACTTATCCATCAAGTGAAGTCGCTCGAC
TTTTCTAACCGTCAGATTCGTTTTGTTGAAAAGGCTCCTAAGCACATAACGGAGAAAGTTTCAGAATTGACTAAGGTTAT
TATTTCCTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT233558 WP_000344800.1 NZ_CP091534:3688636-3689010 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT233558 NZ_HG992743:525463-525720 [Vibrio sp. B1ASS3]
ATGACCGCTGTTACTATCCGTCAATCTGGTGGCGCTAATATAGTTAGCATCCCTAAAGCCATTGTAAAAACGTTGAGTCT
ACATACTGGTTCTAAGCTAGAGTTATCTATTCAAGATAACAACATCGTACTCTCCCCTATCGAGGAAGAATTGACCCTAG
AGTCGGTGTTAGCTGGAAGTCCTAAAACTTGCTTTGCGATTACTGAGGAAGATAAGGAATGGATGAATGACAAGCCTGTT
GGAAAGGAAATAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References