Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 2421357..2421883 | Replicon | chromosome |
| Accession | NZ_CP091534 | ||
| Organism | Escherichia coli strain 537-20 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | L6D13_RS11670 | Protein ID | WP_000323025.1 |
| Coordinates | 2421596..2421883 (+) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | L6D13_RS11665 | Protein ID | WP_000534858.1 |
| Coordinates | 2421357..2421596 (+) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| L6D13_RS11635 (2416719) | 2416719..2417208 | + | 490 | Protein_2283 | class I SAM-dependent methyltransferase | - |
| L6D13_RS11640 (2417686) | 2417686..2418107 | + | 422 | Protein_2284 | hypothetical protein | - |
| L6D13_RS11645 (2418763) | 2418763..2419785 | + | 1023 | Protein_2285 | ISNCY family transposase | - |
| L6D13_RS11650 (2419906) | 2419906..2420055 | + | 150 | WP_011443592.1 | protein YdfW | - |
| L6D13_RS11655 (2420492) | 2420492..2420824 | - | 333 | WP_001301033.1 | FlxA-like family protein | - |
| L6D13_RS11660 (2421027) | 2421027..2421332 | - | 306 | WP_001326990.1 | protein YdfV | - |
| L6D13_RS11665 (2421357) | 2421357..2421596 | + | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| L6D13_RS11670 (2421596) | 2421596..2421883 | + | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| L6D13_RS11675 (2421955) | 2421955..2422110 | + | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
| L6D13_RS11680 (2422327) | 2422327..2422578 | + | 252 | WP_000980994.1 | protein Rem | - |
| L6D13_RS11685 (2422645) | 2422645..2422923 | + | 279 | WP_012304870.1 | hypothetical protein | - |
| L6D13_RS11690 (2422925) | 2422925..2423974 | + | 1050 | WP_001265198.1 | DUF968 domain-containing protein | - |
| L6D13_RS11695 (2423988) | 2423988..2424740 | + | 753 | WP_001047135.1 | antitermination protein | - |
| L6D13_RS11700 (2425018) | 2425018..2425107 | - | 90 | WP_120795389.1 | hypothetical protein | - |
| L6D13_RS11705 (2425162) | 2425162..2425374 | - | 213 | WP_000087756.1 | cold shock-like protein CspF | - |
| L6D13_RS11710 (2425675) | 2425675..2425890 | + | 216 | WP_000066484.1 | cold shock-like protein CspB | - |
| L6D13_RS11715 (2426254) | 2426254..2426424 | - | 171 | WP_211180497.1 | putative zinc-binding protein YnfU | - |
| L6D13_RS11720 (2426644) | 2426644..2426859 | + | 216 | WP_000839590.1 | phage lysis protein EssD | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 2408240..2459849 | 51609 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T233556 WP_000323025.1 NZ_CP091534:2421596-2421883 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T233556 NZ_HG992742:1716879-1717148 [Vibrio sp. B1ASS3]
ATGAGTAGTAGTCAACGTTTACTATCGTGGACTGATGAGGCTTGGGGCGACTATCTGTATTGGCAAACCCAAGATAAGAA
AACACTTAAGCGCATCAACAAACTTATCAATGATGTTAAGCGTTCTCCTTTTGAGGGTATTGGTAAACCTGAGCCGTTAA
AAGAGAACTTATCTGGTTTTTGGTCTCGCCGCATCGACGACACTAATAGGCTTGTTTACGCAGTAGATGATCAAGCGATA
ACAATAATTTCATGTCGCTACCACTACTAA
ATGAGTAGTAGTCAACGTTTACTATCGTGGACTGATGAGGCTTGGGGCGACTATCTGTATTGGCAAACCCAAGATAAGAA
AACACTTAAGCGCATCAACAAACTTATCAATGATGTTAAGCGTTCTCCTTTTGAGGGTATTGGTAAACCTGAGCCGTTAA
AAGAGAACTTATCTGGTTTTTGGTCTCGCCGCATCGACGACACTAATAGGCTTGTTTACGCAGTAGATGATCAAGCGATA
ACAATAATTTCATGTCGCTACCACTACTAA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT233556 WP_000534858.1 NZ_CP091534:2421357-2421596 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT233556 NZ_HG992742:1716632-1716886 [Vibrio sp. B1ASS3]
ATGAGAATCGTATCTTTTACTGAAGCTAGAAATGGTCTTAAAGCTGTTTTGGACGGTGTAGTTAATGACGCAGATACAAC
AGTCATTACACGCCGTGACTCTGAGGATGCTGTGGTTATGTCTTTAGATTACTACAACAGCCTTATGGAGACAGTGCACT
TACTACGTTCTCCTAAGAATGCTGAACACCTAAACCGATCAATAGCACAGTACCGTGCTGGAAACACAACAGCACGAGAG
TTAATTGATGAGTAG
ATGAGAATCGTATCTTTTACTGAAGCTAGAAATGGTCTTAAAGCTGTTTTGGACGGTGTAGTTAATGACGCAGATACAAC
AGTCATTACACGCCGTGACTCTGAGGATGCTGTGGTTATGTCTTTAGATTACTACAACAGCCTTATGGAGACAGTGCACT
TACTACGTTCTCCTAAGAATGCTGAACACCTAAACCGATCAATAGCACAGTACCGTGCTGGAAACACAACAGCACGAGAG
TTAATTGATGAGTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|