Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1948991..1949822 Replicon chromosome
Accession NZ_CP091534
Organism Escherichia coli strain 537-20

Toxin (Protein)


Gene name yeeV Uniprot ID S1P968
Locus tag L6D13_RS09305 Protein ID WP_000854814.1
Coordinates 1948991..1949365 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID B3Y195
Locus tag L6D13_RS09310 Protein ID WP_001285585.1
Coordinates 1949454..1949822 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L6D13_RS09265 (1944387) 1944387..1945553 + 1167 WP_000830170.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -
L6D13_RS09270 (1945672) 1945672..1946145 + 474 WP_001105416.1 DNA gyrase inhibitor SbmC -
L6D13_RS09275 (1946343) 1946343..1947401 + 1059 WP_001200890.1 FUSC family protein -
L6D13_RS09280 (1947573) 1947573..1947902 + 330 WP_000450409.1 DUF496 family protein -
L6D13_RS09285 (1948003) 1948003..1948137 - 135 WP_001297944.1 EutP/PduV family microcompartment system protein -
L6D13_RS09290 (1948257) 1948257..1948385 + 129 Protein_1823 transposase domain-containing protein -
L6D13_RS09295 (1948674) 1948674..1948754 - 81 Protein_1824 hypothetical protein -
L6D13_RS09300 (1948800) 1948800..1948994 - 195 WP_000988600.1 DUF5983 family protein -
L6D13_RS09305 (1948991) 1948991..1949365 - 375 WP_000854814.1 type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA Toxin
L6D13_RS09310 (1949454) 1949454..1949822 - 369 WP_001285585.1 type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA Antitoxin
L6D13_RS09315 (1949896) 1949896..1950117 - 222 WP_000692323.1 DUF987 domain-containing protein -
L6D13_RS09320 (1950180) 1950180..1950656 - 477 WP_001186726.1 RadC family protein -
L6D13_RS09325 (1950672) 1950672..1951151 - 480 WP_000860087.1 antirestriction protein -
L6D13_RS09330 (1951233) 1951233..1952051 - 819 WP_054472832.1 DUF932 domain-containing protein -
L6D13_RS09335 (1952151) 1952151..1952384 - 234 WP_001119729.1 DUF905 family protein -
L6D13_RS09340 (1952463) 1952463..1952918 - 456 WP_000581504.1 IrmA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13898.94 Da        Isoelectric Point: 7.8522

>T233547 WP_000854814.1 NZ_CP091534:c1949365-1948991 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T233547 NZ_HG992342:74395-74664 [Xanthomonas arboricola pv. corylina]
GTGGCCGACCTGGACGCGATTGCCGACTACATTGCGCTTGAGGACGCTGCCGCCGCAGCGGCACTGGTGAGACGGGTGTT
TGCGCATGTCGAGCAATTGGCCGAACACCCGGAGAGTGGAAGCCGGCCGCAGGAGCTCAAGCGCTCCCGCTACCGTCAAA
TCGTCGAGCCACCTTGCCGCGTGTTCTACCGTGTGGACGGGCAACGCGTTGTCGTGGTTCACGTGATGCGCTCGGAGCGG
TTACTTCGGAAGAATCGTCTTTCGCGCTGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13593.48 Da        Isoelectric Point: 6.3139

>AT233547 WP_001285585.1 NZ_CP091534:c1949822-1949454 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT233547 NZ_HG992342:74120-74377 [Xanthomonas arboricola pv. corylina]
ATGCGCACAGAACTTGTCACCACGCTCAAGCGGCAGGCCACCGAGCTCCTCGCAGATGTCGAGCGCGACAAGGAGCCGAT
CCTGATCACCCAGCATGGCCTGCCCAGCGCATACCTGGTGGACGTCGCCAGCTATGAACGCATGCAACAGCGCATGGCGA
TCCTCGAAGGAATTGCCCGTGGTGAAATGGCGGTAGCCGAAGGCCGCAGCCTGAGCCACGAGCAAGCCAAACAACGCCTG
GCGCGATGGCTGAAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FY50

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LW60

References