Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1439130..1439755 Replicon chromosome
Accession NZ_CP091534
Organism Escherichia coli strain 537-20

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag L6D13_RS06965 Protein ID WP_000911330.1
Coordinates 1439357..1439755 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag L6D13_RS06960 Protein ID WP_000450524.1
Coordinates 1439130..1439357 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L6D13_RS06935 (1434933) 1434933..1435403 - 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -
L6D13_RS06940 (1435403) 1435403..1435975 - 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
L6D13_RS06945 (1436121) 1436121..1436999 + 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
L6D13_RS06950 (1437016) 1437016..1438050 + 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
L6D13_RS06955 (1438263) 1438263..1438976 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
L6D13_RS06960 (1439130) 1439130..1439357 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
L6D13_RS06965 (1439357) 1439357..1439755 + 399 WP_000911330.1 type II toxin-antitoxin system VapC family toxin Toxin
L6D13_RS06970 (1439902) 1439902..1440765 + 864 WP_001267507.1 neutral zinc metallopeptidase -
L6D13_RS06975 (1440780) 1440780..1442795 + 2016 WP_000829335.1 tRNA cytosine(34) acetyltransferase TmcA -
L6D13_RS06980 (1442869) 1442869..1443567 + 699 WP_000679812.1 esterase -
L6D13_RS06985 (1443677) 1443677..1443877 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14894.25 Da        Isoelectric Point: 9.2216

>T233545 WP_000911330.1 NZ_CP091534:1439357-1439755 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLVVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

>T233545 NZ_HG992341:c4680323-4680171 [Xanthomonas arboricola pv. corylina]
ATGAAGCGACTGCTGACACTGATGGTACTGGGCCTGTTTTCGGCCGGCGTGATGACTGGCTGCAACACCATGGCCGGCGC
TGGCAAGGACATGCAGGGTGCAGGTGAGAAGGTCGAAAAGAAGGCCGACAATTGCAGCGACGGTAAGTGCTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT233545 WP_000450524.1 NZ_CP091534:1439130-1439357 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp

>AT233545 NZ_HG992341:c4680088-4679954 [Xanthomonas arboricola pv. corylina]
ATGAAGCGTGCAATTGTGCTGCTGGTGCTGTCGGTGTTGTCGGTCGGTATGCTGTCGGGTTGCAACACCGTCGCAGGTGC
CGGCAAGGACGTGCAGGGCGCTGGCGAGAAGGTGGAAGACGCTGCGCGCAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References