Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ypjF-yeeU/CbtA-CbeA
Location 1257065..1257798 Replicon chromosome
Accession NZ_CP091534
Organism Escherichia coli strain 537-20

Toxin (Protein)


Gene name ypjF Uniprot ID -
Locus tag L6D13_RS06090 Protein ID WP_043491403.1
Coordinates 1257065..1257394 (-) Length 110 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag L6D13_RS06095 Protein ID WP_038416562.1
Coordinates 1257433..1257798 (-) Length 122 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L6D13_RS24725 (1252922) 1252922..1253110 + 189 WP_072161517.1 DNA invertase -
L6D13_RS06080 (1253265) 1253265..1253384 + 120 WP_000927517.1 hypothetical protein -
L6D13_RS06085 (1253449) 1253449..1256704 + 3256 Protein_1193 AIDA repeat-containing protein -
L6D13_RS06090 (1257065) 1257065..1257394 - 330 WP_043491403.1 TA system toxin CbtA family protein Toxin
L6D13_RS06095 (1257433) 1257433..1257798 - 366 WP_038416562.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
L6D13_RS06100 (1257824) 1257824..1258045 - 222 WP_038416561.1 DUF987 family protein -
L6D13_RS06105 (1258057) 1258057..1258536 - 480 WP_043491407.1 DNA repair protein RadC -
L6D13_RS06110 (1258547) 1258547..1259014 - 468 WP_038416558.1 antirestriction protein -
L6D13_RS06115 (1259111) 1259111..1259365 - 255 WP_071881512.1 hypothetical protein -
L6D13_RS06120 (1259365) 1259365..1260186 - 822 WP_172426760.1 DUF932 domain-containing protein -
L6D13_RS06125 (1260297) 1260297..1260530 - 234 WP_038416556.1 DUF905 domain-containing protein -
L6D13_RS06130 (1260604) 1260604..1261434 - 831 WP_230042021.1 inhibitor of vertebrate lysozyme family protein -
L6D13_RS06135 (1261608) 1261608..1262018 - 411 WP_038416555.1 hypothetical protein -
L6D13_RS06140 (1262163) 1262163..1262378 - 216 WP_038416553.1 hypothetical protein -
L6D13_RS06145 (1262390) 1262390..1262539 - 150 WP_001458941.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1249504..1281388 31884


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-108)

Antitoxin

Antitoxin CbeA

(17-117)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12384.08 Da        Isoelectric Point: 6.8692

>T233544 WP_043491403.1 NZ_CP091534:c1257394-1257065 [Escherichia coli]
MQTLSLHPTRATPLCLSPVETWQRLLAHLFSQHYGLTLNDTPFSNETTIREHIDAGVSLSDAVNFLVEKYGLVRIDREGF
SWQEQTPYISAVDILRARRSTGLLKTDVK

Download         Length: 330 bp

>T233544 NZ_HG992341:c4680088-4679954 [Xanthomonas arboricola pv. corylina]
ATGAAGCGTGCAATTGTGCTGCTGGTGCTGTCGGTGTTGTCGGTCGGTATGCTGTCGGGTTGCAACACCGTCGCAGGTGC
CGGCAAGGACGTGCAGGGCGCTGGCGAGAAGGTGGAAGACGCTGCGCGCAAGTAA

Antitoxin


Download         Length: 122 a.a.        Molecular weight: 13509.23 Da        Isoelectric Point: 4.7952

>AT233544 WP_038416562.1 NZ_CP091534:c1257798-1257433 [Escherichia coli]
MNNHSESGTKPENPACKQWGLRCTITPCFGARLVQEGNRVHFLADRAGFNGAFSDEDVLRLDQAFSLILKQLELMLTSGE
LNPLYQHCVTLYHNGLTCEADTLGSFGYVYIAIYPDQPEPQ

Download         Length: 366 bp

>AT233544 NZ_HG992341:c4680323-4680171 [Xanthomonas arboricola pv. corylina]
ATGAAGCGACTGCTGACACTGATGGTACTGGGCCTGTTTTCGGCCGGCGTGATGACTGGCTGCAACACCATGGCCGGCGC
TGGCAAGGACATGCAGGGTGCAGGTGAGAAGGTCGAAAAGAAGGCCGACAATTGCAGCGACGGTAAGTGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References