Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 981315..981969 Replicon chromosome
Accession NZ_CP091534
Organism Escherichia coli strain 537-20

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag L6D13_RS04770 Protein ID WP_000244777.1
Coordinates 981562..981969 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag L6D13_RS04765 Protein ID WP_000354046.1
Coordinates 981315..981581 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L6D13_RS04740 (976603) 976603..977346 + 744 WP_000951948.1 SDR family oxidoreductase -
L6D13_RS04745 (977403) 977403..978836 - 1434 WP_001363803.1 6-phospho-beta-glucosidase BglA -
L6D13_RS04750 (978881) 978881..979192 + 312 WP_001182954.1 N(4)-acetylcytidine aminohydrolase -
L6D13_RS04755 (979356) 979356..980015 + 660 WP_096934221.1 hemolysin III family protein -
L6D13_RS04760 (980092) 980092..981072 - 981 WP_000886062.1 tRNA-modifying protein YgfZ -
L6D13_RS04765 (981315) 981315..981581 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
L6D13_RS04770 (981562) 981562..981969 + 408 WP_000244777.1 protein YgfX Toxin
L6D13_RS04775 (982009) 982009..982530 - 522 WP_001055874.1 flavodoxin FldB -
L6D13_RS04780 (982642) 982642..983538 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
L6D13_RS04785 (983563) 983563..984273 + 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
L6D13_RS04790 (984279) 984279..986012 + 1734 WP_000813212.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T233541 WP_000244777.1 NZ_CP091534:981562-981969 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T233541 NZ_HG992338:c4865314-4865162 [Xanthomonas arboricola pv. corylina]
ATGAAGCGACTGCTGACACTGATGGTACTGGGCCTGTTTTCGGCCGGCGTGATGACTGGCTGCAACACCATGGCCGGCGC
TGGCAAGGACATGCAGGGTGCAGGTGAGAAGGTCGAAAAGAAGGCCGACAATTGCAGCGACGGTAAGTGCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT233541 WP_000354046.1 NZ_CP091534:981315-981581 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT233541 NZ_HG992338:c4865079-4864945 [Xanthomonas arboricola pv. corylina]
ATGAAGCGTGCAATTGTGCTGCTGGTGCTGTCGGTGTTGTCGGTCGGTATGCTGTCGGGTTGCAACACCGTCGCAGGTGC
CGGCAAGGACGTGCAGGGCGCTGGCGAGAAGGTGGAAGACGCTGCGCGCAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References