Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 332946..333532 Replicon chromosome
Accession NZ_CP091534
Organism Escherichia coli strain 537-20

Toxin (Protein)


Gene name hicA Uniprot ID A0A0H0RQZ4
Locus tag L6D13_RS01530 Protein ID WP_042014162.1
Coordinates 332946..333176 (+) Length 77 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID U9Y7E1
Locus tag L6D13_RS01535 Protein ID WP_000593555.1
Coordinates 333173..333532 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L6D13_RS01520 (328983) 328983..331718 + 2736 WP_000149132.1 ribosome-associated ATPase/putative transporter RbbA -
L6D13_RS01525 (331718) 331718..332842 + 1125 WP_001314210.1 ABC transporter permease -
L6D13_RS01530 (332946) 332946..333176 + 231 WP_042014162.1 type II toxin-antitoxin system HicA family toxin Toxin
L6D13_RS01535 (333173) 333173..333532 + 360 WP_000593555.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
L6D13_RS01540 (333652) 333652..334053 - 402 WP_001190062.1 nickel-responsive transcriptional regulator NikR -
L6D13_RS01545 (334059) 334059..334865 - 807 WP_000173668.1 nickel import ATP-binding protein NikE -
L6D13_RS01550 (334862) 334862..335626 - 765 WP_001136236.1 nickel import ATP-binding protein NikD -
L6D13_RS01555 (335626) 335626..336459 - 834 WP_001008963.1 nickel ABC transporter permease subunit NikC -
L6D13_RS01560 (336456) 336456..337400 - 945 WP_000947068.1 nickel ABC transporter permease subunit NikB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(15-65)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 77 a.a.        Molecular weight: 8419.79 Da        Isoelectric Point: 8.5518

>T233536 WP_042014162.1 NZ_CP091534:332946-333176 [Escherichia coli]
MDQLFKSPLPQGIKWTDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESVRDWLLSIGVKP

Download         Length: 231 bp

>T233536 NZ_HG992336:c4479074-4478922 [Xanthomonas arboricola]
ATGAAGCGACTGCTGACACTGATGGTACTGGGCCTGTTTTCGGCCGGCGTGATGACTGGCTGCAACACCATGGCCGGCGC
TGGCAAGGACATGCAGGGTGCAGGTGAGAAGGTCGAAAAGAAGGCCGACAATTGCAGCGACGGTAAGTGCTGA

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13402.27 Da        Isoelectric Point: 5.1987

>AT233536 WP_000593555.1 NZ_CP091534:333173-333532 [Escherichia coli]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp

>AT233536 NZ_HG992336:c4478839-4478705 [Xanthomonas arboricola]
ATGAAGCGTGCAATTGTGCTGCTGGTGCTGTCGGTGTTGTCGGTCGGTATGCTGTCGGGTTGCAACACCGTCGCAGGTGC
CGGCAAGGACGTGCAGGGCGCTGGCGAGAAGGTGGAAGACGCTGCGCGCAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H0RQZ4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LKZ6

References