Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 49335..50169 Replicon chromosome
Accession NZ_CP091534
Organism Escherichia coli strain 537-20

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag L6D13_RS00255 Protein ID WP_001518317.1
Coordinates 49335..49712 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag L6D13_RS00260 Protein ID WP_024187829.1
Coordinates 49801..50169 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L6D13_RS00225 (44699) 44699..45622 - 924 WP_000535960.1 carboxylate/amino acid/amine transporter -
L6D13_RS00230 (45733) 45733..46917 - 1185 WP_001172893.1 sugar efflux transporter -
L6D13_RS00235 (47314) 47314..47475 - 162 Protein_46 RhuM family protein -
L6D13_RS00240 (47711) 47711..48556 - 846 WP_001518322.1 DUF4942 domain-containing protein -
L6D13_RS00245 (48641) 48641..48838 - 198 WP_000839251.1 DUF957 domain-containing protein -
L6D13_RS00250 (48850) 48850..49338 - 489 WP_001518318.1 DUF5983 family protein -
L6D13_RS00255 (49335) 49335..49712 - 378 WP_001518317.1 type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA Toxin
L6D13_RS00260 (49801) 49801..50169 - 369 WP_024187829.1 type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA Antitoxin
L6D13_RS00265 (50248) 50248..50469 - 222 WP_000692312.1 DUF987 domain-containing protein -
L6D13_RS00270 (50538) 50538..51014 - 477 WP_001518017.1 RadC family protein -
L6D13_RS00275 (51030) 51030..51503 - 474 WP_001518016.1 antirestriction protein -
L6D13_RS00280 (51597) 51597..51842 - 246 WP_001518015.1 hypothetical protein -
L6D13_RS00285 (51842) 51842..52663 - 822 WP_001518315.1 DUF932 domain-containing protein -
L6D13_RS00290 (52842) 52842..52931 - 90 WP_112031555.1 DUF905 family protein -
L6D13_RS00295 (53074) 53074..53529 - 456 WP_001518314.1 IrmA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13964.02 Da        Isoelectric Point: 8.9341

>T233535 WP_001518317.1 NZ_CP091534:c49712-49335 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITQGKYPEAKR

Download         Length: 378 bp

>T233535 NZ_HG992336:c4478839-4478705 [Xanthomonas arboricola]
ATGAAGCGTGCAATTGTGCTGCTGGTGCTGTCGGTGTTGTCGGTCGGTATGCTGTCGGGTTGCAACACCGTCGCAGGTGC
CGGCAAGGACGTGCAGGGCGCTGGCGAGAAGGTGGAAGACGCTGCGCGCAAGTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13631.41 Da        Isoelectric Point: 6.2044

>AT233535 WP_024187829.1 NZ_CP091534:c50169-49801 [Escherichia coli]
VSDTLPGTTHPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT233535 NZ_HG992336:c4479074-4478922 [Xanthomonas arboricola]
ATGAAGCGACTGCTGACACTGATGGTACTGGGCCTGTTTTCGGCCGGCGTGATGACTGGCTGCAACACCATGGCCGGCGC
TGGCAAGGACATGCAGGGTGCAGGTGAGAAGGTCGAAAAGAAGGCCGACAATTGCAGCGACGGTAAGTGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References