Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4339851..4340508 Replicon chromosome
Accession NZ_CP091527
Organism Klebsiella sp. PCX

Toxin (Protein)


Gene name cptA Uniprot ID A0A2A5MNX1
Locus tag GQR96_RS20680 Protein ID WP_004205323.1
Coordinates 4339851..4340261 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag GQR96_RS20685 Protein ID WP_002916312.1
Coordinates 4340242..4340508 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GQR96_RS20660 (4335851) 4335851..4337584 - 1734 WP_004205327.1 single-stranded-DNA-specific exonuclease RecJ -
GQR96_RS20665 (4337590) 4337590..4338303 - 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
GQR96_RS20670 (4338326) 4338326..4339222 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
GQR96_RS20675 (4339323) 4339323..4339844 + 522 WP_004205324.1 flavodoxin FldB -
GQR96_RS20680 (4339851) 4339851..4340261 - 411 WP_004205323.1 protein YgfX Toxin
GQR96_RS20685 (4340242) 4340242..4340508 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
GQR96_RS20690 (4340754) 4340754..4341737 + 984 WP_049116109.1 tRNA-modifying protein YgfZ -
GQR96_RS20695 (4341894) 4341894..4342553 - 660 WP_004205319.1 hemolysin III family protein -
GQR96_RS20700 (4342716) 4342716..4343027 - 312 WP_004205318.1 N(4)-acetylcytidine aminohydrolase -
GQR96_RS20705 (4343077) 4343077..4343805 + 729 WP_004205316.1 MurR/RpiR family transcriptional regulator -
GQR96_RS20710 (4343924) 4343924..4345357 + 1434 WP_004205314.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16035.83 Da        Isoelectric Point: 11.4778

>T233534 WP_004205323.1 NZ_CP091527:c4340261-4339851 [Klebsiella sp. PCX]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
DWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T233534 NZ_HG969192:c2300844-2300251 [Bartonella tribocorum]
GTGGAGAAATATAAAGGGGGCGGTGATCCTTATACTGATCCTAAAACTGGTGTGATGTATAATCGGTTTGAAATTCAGGA
TAAAACCGCACTGGAGCGTGTAGAATCTACTTTCGCTTATGTAAGGTCTTTTGAACTTATGCGTGCTGCTACGGGTGGTA
AGTTTGATCTCGATCACATGAAAGAGATTCATAGAAAACTGTTTGGTGACGTCTATGAATGGGCGGGAGAGATCCGTTCA
ATAGATATTGCCAAAGGCAATAGTATGTTTGCGAGTTATCATCAGATTGAAAGTTATACACCGAAGATTACGCAACAGCT
TGCAAAAGAACAGTATCTGCGTGGTCTTGATGCAGATGAATTTAGCCAAAGAGCAGGATATTACATGGGAGAGTTGAATG
CCTTGCATCCCTTTCGAGAGGGAAATGGGCGCACGTTGCGTGAATTTATGGGGCAACTTGCTCGTGAAGCTGGTTATAAT
ATCAACTGGGACGGTATCACGCGAGAGGAAATGACAAAGGCATCAATTGCAGCCCATTTTGGGAATTCTGAACACTTGTC
TGTACTTATTCGTCAAAACCTCAATCTCTTATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT233534 WP_002916312.1 NZ_CP091527:c4340508-4340242 [Klebsiella sp. PCX]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT233534 NZ_HG969192:c2301019-2300831 [Bartonella tribocorum]
ATGTTGAGTGAAGACGAAATTAAGCGACGTCGCTTTGCTGCTAAAAATGCATTAGCAAGTCAACGTTTAGAGGGGTTGGA
ACCAGATCCAAAAGTCGTGGAGCAAATGGAGCGGGTTATTATTGGAGAACTTGAAACAAGTGATGTAATCAAGGATCTTA
TGGAACGGATAAAACGTGGAGAAATATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A5MNX1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References