Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hipBA/HipA-HipB |
| Location | 2510981..2512569 | Replicon | chromosome |
| Accession | NZ_CP091527 | ||
| Organism | Klebsiella sp. PCX | ||
Toxin (Protein)
| Gene name | hipA | Uniprot ID | - |
| Locus tag | GQR96_RS11875 | Protein ID | WP_064187239.1 |
| Coordinates | 2511247..2512569 (+) | Length | 441 a.a. |
Antitoxin (Protein)
| Gene name | hipB | Uniprot ID | A0A2A5MFC9 |
| Locus tag | GQR96_RS11870 | Protein ID | WP_004205921.1 |
| Coordinates | 2510981..2511247 (+) | Length | 89 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| GQR96_RS11845 (2506114) | 2506114..2507037 | + | 924 | WP_004205929.1 | LysR family hpxDE operon transcriptional regulator HpxR | - |
| GQR96_RS11850 (2507018) | 2507018..2508172 | - | 1155 | WP_043519552.1 | FAD-dependent urate hydroxylase HpxO | - |
| GQR96_RS11855 (2508518) | 2508518..2509897 | + | 1380 | WP_017900377.1 | nucleobase:cation symporter-2 family protein | - |
| GQR96_RS11860 (2509875) | 2509875..2510375 | + | 501 | WP_017900378.1 | 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase | - |
| GQR96_RS11865 (2510372) | 2510372..2510698 | + | 327 | WP_053810395.1 | hydroxyisourate hydrolase | - |
| GQR96_RS11870 (2510981) | 2510981..2511247 | + | 267 | WP_004205921.1 | type II toxin-antitoxin system antitoxin HipB | Antitoxin |
| GQR96_RS11875 (2511247) | 2511247..2512569 | + | 1323 | WP_064187239.1 | type II toxin-antitoxin system HipA family toxin | Toxin |
| GQR96_RS11880 (2512586) | 2512586..2513878 | - | 1293 | WP_023318214.1 | glycoside hydrolase family 10 protein | - |
| GQR96_RS11885 (2514020) | 2514020..2514226 | - | 207 | WP_004205917.1 | helix-turn-helix transcriptional regulator | - |
| GQR96_RS11890 (2514229) | 2514229..2514762 | - | 534 | WP_053810394.1 | hypothetical protein | - |
| GQR96_RS11895 (2514791) | 2514791..2515135 | - | 345 | WP_004205915.1 | hypothetical protein | - |
| GQR96_RS11900 (2515122) | 2515122..2516237 | - | 1116 | WP_065904746.1 | serine hydrolase domain-containing protein | - |
| GQR96_RS11905 (2516506) | 2516506..2517288 | - | 783 | WP_065904745.1 | type I methionyl aminopeptidase | - |
| GQR96_RS11910 (2517269) | 2517269..2517487 | - | 219 | WP_002904808.1 | ParD-like family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 441 a.a. Molecular weight: 49026.36 Da Isoelectric Point: 8.6091
>T233524 WP_064187239.1 NZ_CP091527:2511247-2512569 [Klebsiella sp. PCX]
MATLTTWMNNARVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRERIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLAALRWQTLDEAQLTALLTAYQSDIPLGMVTGQDDFRISVAGAQEKTAL
LRMGEHWCIPQGTTPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARALGLAVPEAEIINTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGIPSSMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSLFLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILGEFADRVP
QAIESARRTLPSDFSAHVWRAITENMLKLHARLQQGLLAG
MATLTTWMNNARVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRERIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLAALRWQTLDEAQLTALLTAYQSDIPLGMVTGQDDFRISVAGAQEKTAL
LRMGEHWCIPQGTTPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARALGLAVPEAEIINTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGIPSSMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSLFLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILGEFADRVP
QAIESARRTLPSDFSAHVWRAITENMLKLHARLQQGLLAG
Download Length: 1323 bp
>T233524 NZ_HG969192:491439-491708 [Bartonella tribocorum]
TTGGCTTGGACGATTAGATATGAAAAAAAAGCTCTTAGTTTTTTAAAAAAATGCGATAAAAAAGAAGCACGGAGGATTGT
TGATTTTTTAGATCAACACGTTGCTCCTCTTGAAGATGTGCGTGTAATAGGTAAGCCCTTAAAAGGACAATTATCAGGTT
TATGGAGATATCGTGTAGGAGATTACAGGATACTTTGTGAACTCTATGATAAGAAGCTTGTCGTATTAGTTTTGGCTGTT
GGACATAGAAAAAATATATATAAAGGTTAA
TTGGCTTGGACGATTAGATATGAAAAAAAAGCTCTTAGTTTTTTAAAAAAATGCGATAAAAAAGAAGCACGGAGGATTGT
TGATTTTTTAGATCAACACGTTGCTCCTCTTGAAGATGTGCGTGTAATAGGTAAGCCCTTAAAAGGACAATTATCAGGTT
TATGGAGATATCGTGTAGGAGATTACAGGATACTTTGTGAACTCTATGATAAGAAGCTTGTCGTATTAGTTTTGGCTGTT
GGACATAGAAAAAATATATATAAAGGTTAA
Antitoxin
Download Length: 89 a.a. Molecular weight: 9940.38 Da Isoelectric Point: 7.1997
>AT233524 WP_004205921.1 NZ_CP091527:2510981-2511247 [Klebsiella sp. PCX]
MNSPQIYSPVQLANYLKLLRQQNHWTQEALASRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKPAETAMIP
DNTTDLDW
MNSPQIYSPVQLANYLKLLRQQNHWTQEALASRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKPAETAMIP
DNTTDLDW
Download Length: 267 bp
>AT233524 NZ_HG969192:491228-491455 [Bartonella tribocorum]
ATGACGATATCTATTCGGTTGCCAAGTGATCTCGAAACACGTTTGAATAATTTAGCTGCTAAGACAGGACGTACAAAGTC
TTTTTATTTACGCGAGATTATTGAACGTGGAATAGAGGAAGCGGAGGATTATTATTTAGCTTCACAAGTAAGAGAGCGCG
TTCGAAGGGGAGAGGGTACTTTTTATAGCTCTGAAGAGGTGAGGAAAGAGCTTGGCTTGGACGATTAG
ATGACGATATCTATTCGGTTGCCAAGTGATCTCGAAACACGTTTGAATAATTTAGCTGCTAAGACAGGACGTACAAAGTC
TTTTTATTTACGCGAGATTATTGAACGTGGAATAGAGGAAGCGGAGGATTATTATTTAGCTTCACAAGTAAGAGAGCGCG
TTCGAAGGGGAGAGGGTACTTTTTATAGCTCTGAAGAGGTGAGGAAAGAGCTTGGCTTGGACGATTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|