Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1222155..1222774 Replicon chromosome
Accession NZ_CP091527
Organism Klebsiella sp. PCX

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag GQR96_RS05720 Protein ID WP_002892050.1
Coordinates 1222155..1222373 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag GQR96_RS05725 Protein ID WP_002892066.1
Coordinates 1222400..1222774 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GQR96_RS05685 (1218199) 1218199..1218462 + 264 WP_004204754.1 type B 50S ribosomal protein L31 -
GQR96_RS05690 (1218462) 1218462..1218602 + 141 WP_002892018.1 type B 50S ribosomal protein L36 -
GQR96_RS05695 (1218599) 1218599..1219297 - 699 WP_064187826.1 GNAT family protein -
GQR96_RS05700 (1219398) 1219398..1220855 + 1458 WP_065903537.1 PLP-dependent aminotransferase family protein -
GQR96_RS05705 (1220824) 1220824..1221294 - 471 WP_004204751.1 YlaC family protein -
GQR96_RS05710 (1221337) 1221337..1221459 + 123 WP_032426076.1 hypothetical protein -
GQR96_RS05715 (1221431) 1221431..1221997 - 567 WP_004204750.1 maltose O-acetyltransferase -
GQR96_RS05720 (1222155) 1222155..1222373 - 219 WP_002892050.1 HHA domain-containing protein Toxin
GQR96_RS05725 (1222400) 1222400..1222774 - 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
GQR96_RS05730 (1223259) 1223259..1226405 - 3147 WP_004204748.1 multidrug efflux RND transporter permease subunit AcrB -
GQR96_RS05735 (1226428) 1226428..1227621 - 1194 WP_004204747.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T233523 WP_002892050.1 NZ_CP091527:c1222373-1222155 [Klebsiella sp. PCX]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T233523 NZ_HG969192:490691-491017 [Bartonella tribocorum]
ATGAGGCGTGGTGATATCTATATGGTAGATTTGGAACCAATCCAAGGACGAGAGCAGCGTGGGTATCGTCCTGTCGTCAT
TGTTTCTCCTGATGATTTTAATCAAGCAACAGGTTTACCAGTTATTTTGCCGATCACAAGCGGTGGAAATTTTGTTCGCC
GTATTGGATTTGCAGTGCCGCTTACGGGTACAAGAACGAGGGGTGTTATTCGTTGCGATCAGCCTCGTGTTCTCGATTTG
GTGGTGCGCAATGGGCGTAAAGTAGAAAGTTTGCCAACAGTTATTATGAATGAAGTATTAGCGAAGGTTGTCACGATCTT
TAGTTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT233523 WP_002892066.1 NZ_CP091527:c1222774-1222400 [Klebsiella sp. PCX]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT233523 NZ_HG969192:490437-490694 [Bartonella tribocorum]
ATGCACACAACAAAATTACGTAAAGTTGGAGGATCAGTGATGCTCTCCATCCCACCTGCATTGCTTGATGTTCTTCACTT
GACTGAAAATAGCGAAGTTGGTTTGGCTATTGATAATGGTCGTCTTGTCGTGGGACCATCAGTCCAGCCGCGATACACGA
TGGCTGAGTTATTAGCTGCCTCCGATTATTCGCAACCACAATCACCTGAAGACCGTGAGTGGGTTGATTCCTCTGCTGTA
GGGGGCGAGCTTATATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References