Detailed information of TA system TA233522

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 512598..513111
• Replicon: chromosome
• Accession: NZ_CP091527
• Organism: Klebsiella sp. PCX

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: GQR96_RS02405
• Protein ID: WP_064190102.1
• Coordinates: 512830..513111 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: R4Y888
• Locus tag: GQR96_RS02400
• Protein ID: WP_002886901.1
• Coordinates: 512598..512840 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GQR96_RS02385 (508629)	508629..509369	+	741	WP_004206507.1	KDGP aldolase family protein	-
GQR96_RS02390 (509436)	509436..510587	+	1152	WP_065878155.1	lactonase family protein	-
GQR96_RS02395 (510610)	510610..512520	+	1911	WP_057212387.1	PRD domain-containing protein	-
GQR96_RS02400 (512598)	512598..512840	+	243	WP_002886901.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
GQR96_RS02405 (512830)	512830..513111	+	282	WP_064190102.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
GQR96_RS02410 (513115)	513115..513579	-	465	WP_064190101.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
GQR96_RS02415 (513890)	513890..516028	-	2139	WP_004206513.1	anaerobic ribonucleoside-triphosphate reductase	-
GQR96_RS02420 (516414)	516414..518069	-	1656	WP_064178460.1	alpha,alpha-phosphotrehalase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (18-82)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-80)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 11031.81 Da
• Isoelectric Point: 10.1752

>T233522 WP_064190102.1 NZ_CP091527:512830-513111 [Klebsiella sp. PCX]
MTYELEFDPRAWREWQLGETVKKQFKNNLQQIMQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGKR
EKAAVYHQANKRL

Nucleotide

• Length: 282 bp

>T233522 NZ_HG969192:c488937-488614 [Bartonella tribocorum]
ATGCGTGGATCTCTCGTCACAATAGCTATGCAAGGCGATTTTGGTAAACCAAGACCTGCGTTAATCATTCAAGCCAATCA
ATTTAGTGAACATACAAGCGTAACGGTTTTACCCATTACCAGCACACTTGTTGATACGCCATTACTTCGCATTACTCTCC
AACCGGACAGCAAAAATGGTTTACAAAAAACTTCTCAAGTCATGATTGATAAAATTATGACGGTAAGATGTGAAAAAGTT
AGTCCAGCTTTTGGCTCCATTCATGCAGATAAAATGGTGGAAATTGAACGCTGCTTAGCTGTATTTTTGGGAATAGTAAA
ATAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9045.55 Da
• Isoelectric Point: 6.3340

>AT233522 WP_002886901.1 NZ_CP091527:512598-512840 [Klebsiella sp. PCX]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Nucleotide

• Length: 243 bp

>AT233522 NZ_HG969192:c489161-488937 [Bartonella tribocorum]
ATGGCTACAATGCACGTTAATGAACGCGTTCAAAAACATCGCAACGCACAAAGAAAAGCAGGTTTGCGCTTAATGCAAAT
TTGGGTACCAGATACTCGTCAACCAAACTTTGCAGAAGAGTGCCGACGCCAATGTCGCTTAGTCGCAAAAATGGATAAAA
CAGATACATCTATGCAGTTGTTAATGGATCAATCTTTAATGGATATTGATGGCTGGACAGAATGA

Structures

Antitoxin

• AlphaFold DB: A0A0H3GLP0