Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TscAT/-
Location 2835624..2836153 Replicon chromosome
Accession NZ_CP091525
Organism Staphylococcus aureus strain N09CSA16

Toxin (Protein)


Gene name TscT Uniprot ID K7ZRX2
Locus tag L4X60_RS14035 Protein ID WP_001103933.1
Coordinates 2835836..2836153 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name TscA Uniprot ID A0A6B0BJC0
Locus tag L4X60_RS14030 Protein ID WP_001058487.1
Coordinates 2835624..2835833 (+) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L4X60_RS13995 (2830855) 2830855..2831139 + 285 WP_000917289.1 co-chaperone GroES -
L4X60_RS14000 (2831215) 2831215..2832831 + 1617 WP_000240642.1 chaperonin GroEL -
L4X60_RS14005 (2832900) 2832900..2834072 - 1173 WP_000179353.1 tyrosine-type recombinase/integrase -
L4X60_RS14010 (2834086) 2834086..2834793 - 708 WP_228766634.1 helix-turn-helix transcriptional regulator -
L4X60_RS14015 (2834961) 2834961..2835167 + 207 WP_000794657.1 helix-turn-helix transcriptional regulator -
L4X60_RS14020 (2835171) 2835171..2835488 + 318 WP_000481968.1 helix-turn-helix domain-containing protein -
L4X60_RS14025 (2835485) 2835485..2835631 + 147 WP_000708434.1 hypothetical protein -
L4X60_RS14030 (2835624) 2835624..2835833 + 210 WP_001058487.1 hypothetical protein Antitoxin
L4X60_RS14035 (2835836) 2835836..2836153 + 318 WP_001103933.1 DUF1474 family protein Toxin
L4X60_RS14040 (2836220) 2836220..2837089 + 870 WP_001002699.1 primase alpha helix C-terminal domain-containing protein -
L4X60_RS14045 (2837106) 2837106..2838575 + 1470 WP_001838755.1 virulence-associated E family protein -
L4X60_RS14050 (2838861) 2838861..2839223 + 363 WP_001039169.1 hypothetical protein -
L4X60_RS14055 (2839225) 2839225..2839509 + 285 WP_000998179.1 hypothetical protein -
L4X60_RS14060 (2839506) 2839506..2840147 + 642 WP_001019811.1 hypothetical protein -
L4X60_RS14065 (2840683) 2840683..2841024 + 342 WP_001190614.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1474

(1-98)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12511.13 Da        Isoelectric Point: 4.6364

>T233521 WP_001103933.1 NZ_CP091525:2835836-2836153 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKEKINDVAIKHGWFVEDKFVKNELETKQEHINFSASYLEHRIQNEHTVELLQVYLKEFGELIQKF
HEIEKASSENFGEESDDAKKLKITE

Download         Length: 318 bp

>T233521 NZ_HG969192:476496-476777 [Bartonella tribocorum]
ATGGCAATTGTGAGTTTCAAACATAAGGGCTTAAAATTATTTTACACAACAGGTTCCACAAAAGCTATTCGACCAGATCA
CGTAAAGAAATTACGCGTTATCTTAACGGCTTTAACAAGTGCTACGACACCTGATATGTTGAGAGCGCCTGCCTTTAAAA
TGCATCCTCTTAAAGGCGAACTTACAGGATATTATTCTATATGGGTGAATGGAAATTGGCGTGTTACTTTTCGCTTTATA
GGAACAGATGTGGAGCTTGTTGATTATCAAGATTACCACTGA

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 8228.24 Da        Isoelectric Point: 4.1682

>AT233521 WP_001058487.1 NZ_CP091525:2835624-2835833 [Staphylococcus aureus]
MNNEQKEVIEHVVYQLELSIMNNFESYEHTEYVDGIEVVSEISPEKHLELIMKWCAQELKNNFQLEKGE

Download         Length: 210 bp

>AT233521 NZ_HG969192:476796-477095 [Bartonella tribocorum]
ATGATGCATAACCCCGCACATCCGGGCGAAGTTCTAAAAGTAGCTTTCTTAGAAGAAATGGGGATAACAATACAGAAATT
AGCTGATCATCTCCATATGACAAGAGCTTCTCTATCAAGAGTGATTAACGGTCATGCTTCTATAAGTACCGAACTTGCAA
TTAAATTAGAATTAGCTGGTTTTAGTAAAGCAAAATTTTGGCTGGATATGCAAACAAACTATAATTTATGGCAAACAATG
CAACAGACACAACCACCTATTTCTCCTCTGGTTTCTGATGTATCTCAAACGCAGCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB K7ZRX2

Antitoxin

Source ID Structure
AlphaFold DB A0A6B0BJC0

References