Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2762483..2762997 Replicon chromosome
Accession NZ_CP091525
Organism Staphylococcus aureus strain N09CSA16

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag L4X60_RS13665 Protein ID WP_000581792.1
Coordinates 2762788..2762997 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag L4X60_RS13660 Protein ID WP_000138932.1
Coordinates 2762483..2762776 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L4X60_RS13640 (2758019) 2758019..2759338 + 1320 WP_001557163.1 ISL3-like element IS1181 family transposase -
L4X60_RS13645 (2759341) 2759341..2759412 + 72 Protein_2654 hypothetical protein -
L4X60_RS13650 (2760155) 2760155..2760802 - 648 WP_001187630.1 HD domain-containing protein -
L4X60_RS13655 (2760830) 2760830..2762317 - 1488 WP_254241334.1 cardiolipin synthase -
L4X60_RS13660 (2762483) 2762483..2762776 + 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
L4X60_RS13665 (2762788) 2762788..2762997 + 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
L4X60_RS13670 (2763125) 2763125..2763262 + 138 WP_000828354.1 Lmo0850 family protein -
L4X60_RS13675 (2763526) 2763526..2764728 - 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
L4X60_RS13680 (2765046) 2765046..2766116 + 1071 WP_000159631.1 D-alanine--D-alanine ligase -
L4X60_RS13685 (2766131) 2766131..2767489 + 1359 WP_000611464.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2758019..2759338 1319


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T233519 WP_000581792.1 NZ_CP091525:2762788-2762997 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T233519 NZ_HG969192:398046-398360 [Bartonella tribocorum]
ATGATACATAAAAGAACGCATAGAGGTGATTTGGTGATTGAATCTTTTGCGGATAAGCGGTGTAAAGATCTTTTAGAAGG
CAAGACACCCAAAGGTTTTCCTGCGACATTGGTACGCATAGCACAAAGAAAATTGTTTATGCTCGATAAAGCAGTTGATC
TTAAAGATTTGCGCAGTCCTCCAGGAAATCATTTAGAAGCATTGAAAGGAGAGCGTAAAGGTCAATATTCTATTCGTATT
AATAACCAGTTTCGTCTTTGTTTTGAATGGCGTACTAATGGTGCCTATGAAGTTGAAATTGTAGATTATCATTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT233519 WP_000138932.1 NZ_CP091525:2762483-2762776 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT233519 NZ_HG969192:398377-398673 [Bartonella tribocorum]
ATGAAAAATTATATTGCAATACATCCTGGAGAAATTTTACGGGAGGAATATTTAAAAGAATATGCTCTTTCTGCTTATGC
TCTTGCAAAAGCATTGAATGTTCCACGCACGAGGATAGAACGTATTATTGCGGAAAATAGCCCAATAACTCCTGATACCG
CTCTCAGACTGGCTTCTTTTTTTGATACGACAGCTGAGTTCTGGCTTAATATGCAAGCTGCTTATGATGTTCATATTTTA
CAAGCCGAAAAAGCAGATGAATTTGCCAAAATTAATAAATTTGAATGTAGAACTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References