Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/Txe-RelB
Location 2385833..2386356 Replicon chromosome
Accession NZ_CP091525
Organism Staphylococcus aureus strain N09CSA16

Toxin (Protein)


Gene name relE Uniprot ID A0A3A5LQI3
Locus tag L4X60_RS11705 Protein ID WP_000074049.1
Coordinates 2386090..2386356 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag L4X60_RS11700 Protein ID WP_000587616.1
Coordinates 2385833..2386090 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L4X60_RS11685 (2382330) 2382330..2383079 - 750 WP_000072461.1 CPBP family lipoprotein N-acylation protein LnsB -
L4X60_RS11690 (2383274) 2383274..2384851 + 1578 WP_000143494.1 FMN-binding glutamate synthase family protein -
L4X60_RS11695 (2385019) 2385019..2385474 - 456 WP_000732076.1 DUF1307 domain-containing protein -
L4X60_RS11700 (2385833) 2385833..2386090 + 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
L4X60_RS11705 (2386090) 2386090..2386356 + 267 WP_000074049.1 Txe/YoeB family addiction module toxin Toxin
L4X60_RS11710 (2386711) 2386711..2387787 + 1077 WP_001076673.1 M42 family metallopeptidase -
L4X60_RS11715 (2388035) 2388035..2388697 + 663 WP_000923526.1 ATP-binding cassette domain-containing protein -
L4X60_RS11720 (2388690) 2388690..2389466 + 777 WP_000072149.1 iron export ABC transporter permease subunit FetB -
L4X60_RS11725 (2389862) 2389862..2391049 + 1188 WP_000026189.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10676.24 Da        Isoelectric Point: 10.1597

>T233511 WP_000074049.1 NZ_CP091525:2386090-2386356 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLRKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T233511 NZ_HG969191:c892459-892187 [Bartonella henselae]
ATGAAGCTCGTTTGGACACGGATAGCGCATTACGATCGTCAAAAGATACGGGAATATATCGCGCAAGAAAATCCTTCTGC
TGCATTAGTATTCGACAAGCTTTTATCTAAAAAAGTAGAAAGACTCATTAGCTTTCCTAATCTTGGTCGTGTTGGCCGAA
TTAGGAATACGCGCGAGCTTATTGTGCGTAAGAATTATATTATGATTTATGATGTTTCTAATGGCACTATACGGGTTTTG
CGCATACTTCACGCAAAACAAAAGTGGCCATAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT233511 WP_000587616.1 NZ_CP091525:2385833-2386090 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT233511 NZ_HG969191:c892746-892456 [Bartonella henselae]
ATGGCTGAAACAACATTTACCTTTCGCGTTGATGATGTATTAAAAAGTGAATTTTCTCGGGCTGCAAAAGCATGTGATCG
ATCTGCTGCACAGCTCTTACGGGATTACATGCGTGATATTGTAAAAGAACAAAAAGAAAAGATAGCGCATGAATTATGGT
TTCAAGAACAAGTCCAACTTGGATTGAATTCTGCCAACGCAGGTGATGTAATACCTTTTGAAGAAATTGAAACAGAAGCA
CAAGCATGGCGCTTTGAAATACAACGCAAGCTGAAGACATCAGATTCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3A5LQI3

Antitoxin

Source ID Structure
PDB 7V6W
PDB 7V5Z
PDB 7V5Y
AlphaFold DB W8TQT5

References