Detailed information of TA system TA233510

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsaAT/-
• Location: 1212144..1212621
• Replicon: chromosome
• Accession: NZ_CP091525
• Organism: Staphylococcus aureus strain N09CSA16

Toxin (Protein)

• Gene name: TsaT
• Uniprot ID: T1Y7S2
• Locus tag: L4X60_RS06110
• Protein ID: WP_000052076.1
• Coordinates: 1212433..1212621 (+)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: TsaA
• Uniprot ID: T1Y6P8
• Locus tag: L4X60_RS06105
• Protein ID: WP_001059690.1
• Coordinates: 1212144..1212404 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L4X60_RS06070 (1207536)	1207536..1208252	-	717	WP_000150011.1	type I 3-dehydroquinate dehydratase	-
L4X60_RS06075 (1208400)	1208400..1208822	+	423	WP_000974460.1	organic hydroperoxide resistance protein	-
L4X60_RS06080 (1209221)	1209221..1209715	+	495	WP_000569884.1	GNAT family N-acetyltransferase	-
L4X60_RS06085 (1209870)	1209870..1210486	+	617	Protein_1172	LysE/ArgO family amino acid transporter	-
L4X60_RS06090 (1210559)	1210559..1211140	-	582	WP_001140693.1	histidine phosphatase family protein	-
L4X60_RS06095 (1211367)	1211367..1211603	+	237	WP_000349581.1	hypothetical protein	-
L4X60_RS06100 (1211600)	1211600..1211803	-	204	WP_000145163.1	sterile alpha motif-like domain-containing protein	-
L4X60_RS06105 (1212144)	1212144..1212404	+	261	WP_001059690.1	hypothetical protein	Antitoxin
L4X60_RS06110 (1212433)	1212433..1212621	+	189	WP_000052076.1	hypothetical protein	Toxin
L4X60_RS06115 (1212809)	1212809..1213378	+	570	WP_001106654.1	lipoprotein N-acylation protein LnsA	-
L4X60_RS06120 (1213466)	1213466..1213750	+	285	WP_001004399.1	hypothetical protein	-
L4X60_RS06125 (1213812)	1213812..1214030	+	219	WP_000005886.1	hypothetical protein	-
L4X60_RS06130 (1214522)	1214522..1214722	-	201	WP_001059082.1	cold-shock protein	-
L4X60_RS06135 (1215079)	1215079..1215765	-	687	WP_000141557.1	thermonuclease family protein	-
L4X60_RS06140 (1216106)	1216106..1216627	-	522	WP_153906492.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-87)

Antitoxin

• Protein of unknown function DUF6290 (2-71)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7142.82 Da
• Isoelectric Point: 9.9971

>T233510 WP_000052076.1 NZ_CP091525:1212433-1212621 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Nucleotide

• Length: 189 bp

>T233510 NZ_HG969191:789320-789589 [Bartonella henselae]
TTGGCTTGGACGATTAGATATGAAAAAAAAGCTCTCAGTTTTTTAAAAAAATGCGATAAAAAAGAAGCACGGCGGATTGT
TGATTTTTTAGATCAACACGTTGCTCCTCTTGAAGATGTGCGTGTAATAGGTAAGCCCTTAAAAGGACAATTCCCAGGTT
TATGGAGATATCGTGTAGGAGATTACAGGATACTTTGTGAACTCTATGATAAGGAGCTTGTCGTATTAGTTTTGGCTGTT
GGACATAGAAAAAATATATATAAAGGTTAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9940.09 Da
• Isoelectric Point: 4.0624

>AT233510 WP_001059690.1 NZ_CP091525:1212144-1212404 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Nucleotide

• Length: 261 bp

>AT233510 NZ_HG969191:789109-789336 [Bartonella henselae]
ATGACGATATCTATTCGGTTGCCAAGTGATCTCGAAACACGTTTGAATAATTTAGCTGCTAAGACAGGACGTACAAAGTC
TTTTTATTTACGCGAGATTATTGAACGTGGCATAGAGGAAGCAGAGGATTATTATTTAGCCTCACAAGTAAGAGAGCGCG
TTCGAAGGGGAGAGGGTACTTTTTATAGCTCTGAAGAGGTGAGGAAAGAGCTTGGCTTGGACGATTAG

Structures

Toxin

• AlphaFold DB: A0A0E0VP18

Antitoxin

• AlphaFold DB: A0A0E0VN56