Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /HTH_19(antitoxin) |
| Location | 505287..506075 | Replicon | chromosome |
| Accession | NZ_CP091525 | ||
| Organism | Staphylococcus aureus strain N09CSA16 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | A0A2I7Y5B3 |
| Locus tag | L4X60_RS02705 | Protein ID | WP_000525004.1 |
| Coordinates | 505287..505748 (-) | Length | 154 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | - |
| Locus tag | L4X60_RS02710 | Protein ID | WP_000333631.1 |
| Coordinates | 505761..506075 (-) | Length | 105 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| L4X60_RS02680 (500297) | 500297..502324 | + | 2028 | WP_001558502.1 | hypothetical protein | - |
| L4X60_RS02685 (502367) | 502367..503572 | - | 1206 | WP_000264751.1 | site-specific integrase | - |
| L4X60_RS02690 (503698) | 503698..504312 | + | 615 | WP_000191470.1 | hypothetical protein | - |
| L4X60_RS02695 (504309) | 504309..504455 | - | 147 | WP_001795334.1 | hypothetical protein | - |
| L4X60_RS02700 (504685) | 504685..505269 | - | 585 | WP_000825949.1 | hypothetical protein | - |
| L4X60_RS02705 (505287) | 505287..505748 | - | 462 | WP_000525004.1 | hypothetical protein | Toxin |
| L4X60_RS02710 (505761) | 505761..506075 | - | 315 | WP_000333631.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| L4X60_RS02715 (506227) | 506227..506463 | + | 237 | WP_001121027.1 | helix-turn-helix transcriptional regulator | - |
| L4X60_RS02720 (506477) | 506477..507253 | + | 777 | WP_153906478.1 | Rha family transcriptional regulator | - |
| L4X60_RS02725 (507282) | 507282..507527 | + | 246 | WP_001025401.1 | DUF2829 domain-containing protein | - |
| L4X60_RS02730 (507496) | 507496..507861 | - | 366 | WP_001128433.1 | hypothetical protein | - |
| L4X60_RS02735 (507916) | 507916..508131 | + | 216 | WP_001097552.1 | hypothetical protein | - |
| L4X60_RS02740 (508158) | 508158..508421 | + | 264 | WP_001124194.1 | helix-turn-helix domain-containing protein | - |
| L4X60_RS02745 (508434) | 508434..508595 | + | 162 | WP_001285948.1 | DUF1270 domain-containing protein | - |
| L4X60_RS02750 (508674) | 508674..508997 | + | 324 | WP_000174999.1 | hypothetical protein | - |
| L4X60_RS02755 (509012) | 509012..509374 | + | 363 | WP_000985972.1 | hypothetical protein | - |
| L4X60_RS02760 (509371) | 509371..510537 | + | 1167 | WP_000762552.1 | DUF2800 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 154 a.a. Molecular weight: 18074.46 Da Isoelectric Point: 4.6915
>T233506 WP_000525004.1 NZ_CP091525:c505748-505287 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI
Download Length: 462 bp
>T233506 NZ_HG969191:c389642-389466 [Bartonella henselae]
ATGGAACAAAATAGCCGAAAGATAATTGCAAAATTAAAACGCGATGGCTTTGAACTTGTCAAAGTAAAAGGTTCGCACCA
TAAATTTAAAAAAGATGGTAAGGTTGTTATTGTCCCACATCCTAAAAAAAATCTTCCAATTGGTACAGCGCATTCTATTG
CACAACAAGCAGGCTGA
ATGGAACAAAATAGCCGAAAGATAATTGCAAAATTAAAACGCGATGGCTTTGAACTTGTCAAAGTAAAAGGTTCGCACCA
TAAATTTAAAAAAGATGGTAAGGTTGTTATTGTCCCACATCCTAAAAAAAATCTTCCAATTGGTACAGCGCATTCTATTG
CACAACAAGCAGGCTGA
Antitoxin
Download Length: 105 a.a. Molecular weight: 12062.58 Da Isoelectric Point: 7.1661
>AT233506 WP_000333631.1 NZ_CP091525:c506075-505761 [Staphylococcus aureus]
MCFSKRMKQSREKQGMTLAELGRKIGKTEATVQRYESGNIKNLKNDTIESIATALNVNPAYLMGWVEENDDEVQHRAAHL
EGELTDDEWQRVLDYANYIRSKRK
MCFSKRMKQSREKQGMTLAELGRKIGKTEATVQRYESGNIKNLKNDTIESIATALNVNPAYLMGWVEENDDEVQHRAAHL
EGELTDDEWQRVLDYANYIRSKRK
Download Length: 315 bp
>AT233506 NZ_HG969191:c389445-389050 [Bartonella henselae]
ATGAAAAGATTTTTTGCTCTTGTTCATAAAGATGAGGATTCTGCTTTTGGTGTTCAATTTCCTGATTTTGAAGGTCTATT
CTCTGCTGCTGATGAAGAAGAAACTCTTATCATAAATGCAACCGAAGCTTTGCAACTTTACTGTGAAGATATGGATACAG
TGCCTGTTCCTTTAAAATTTGAAGAAGTGATACAACAGAAAGCTGTCAAAAAAGCTTTGTCAGAAGGAGCTTTTTTAATA
CAAGTTCCTTTTATTGAAAATGATTCAGAAGTCGTACGTACAAATATATCAATTGAACGAGGGCTTTTGCGTGCAATTGA
TAATTGTGCACAAGAGAGAGGGTTAACAAGATCTGCTTTTTTGGCAACAGCAGCCCGTCACGAGCTTAATATTTAG
ATGAAAAGATTTTTTGCTCTTGTTCATAAAGATGAGGATTCTGCTTTTGGTGTTCAATTTCCTGATTTTGAAGGTCTATT
CTCTGCTGCTGATGAAGAAGAAACTCTTATCATAAATGCAACCGAAGCTTTGCAACTTTACTGTGAAGATATGGATACAG
TGCCTGTTCCTTTAAAATTTGAAGAAGTGATACAACAGAAAGCTGTCAAAAAAGCTTTGTCAGAAGGAGCTTTTTTAATA
CAAGTTCCTTTTATTGAAAATGATTCAGAAGTCGTACGTACAAATATATCAATTGAACGAGGGCTTTTGCGTGCAATTGA
TAATTGTGCACAAGAGAGAGGGTTAACAAGATCTGCTTTTTTGGCAACAGCAGCCCGTCACGAGCTTAATATTTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|