Detailed information of TA system TA233503

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 121150..121926
• Replicon: chromosome
• Accession: NZ_CP091525
• Organism: Staphylococcus aureus strain N09CSA16

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: X5E2E6
• Locus tag: L4X60_RS00770
• Protein ID: WP_000031108.1
• Coordinates: 121774..121926 (+)
• Length: 51 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: W8U4V4
• Locus tag: L4X60_RS00765
• Protein ID: WP_001251224.1
• Coordinates: 121150..121749 (+)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L4X60_RS00745 (117066)	117066..118523	+	1458	WP_000649908.1	ABC transporter permease subunit	-
L4X60_RS00750 (118516)	118516..119238	+	723	WP_000590809.1	amino acid ABC transporter ATP-binding protein	-
L4X60_RS00755 (119389)	119389..120516	+	1128	WP_000379980.1	tRNA epoxyqueuosine(34) reductase QueG	-
L4X60_RS00760 (120521)	120521..120991	+	471	WP_000181394.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
L4X60_RS00765 (121150)	121150..121749	+	600	WP_001251224.1	glucosamine-6-phosphate isomerase	Antitoxin
L4X60_RS00770 (121774)	121774..121926	+	153	WP_000031108.1	SAS053 family protein	Toxin
L4X60_RS00775 (122474)	122474..122869	+	396	WP_000901023.1	hypothetical protein	-
L4X60_RS00780 (123065)	123065..124450	+	1386	WP_000116228.1	class II fumarate hydratase	-
L4X60_RS00785 (124903)	124903..125724	-	822	WP_000669376.1	RluA family pseudouridine synthase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (124-196)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5936.28 Da
• Isoelectric Point: 3.8962

>T233503 WP_000031108.1 NZ_CP091525:121774-121926 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Nucleotide

• Length: 153 bp

>T233503 NZ_HG969191:371293-371616 [Bartonella henselae]
ATGCGTGGATCTCTCGTCACAATAGCGATGCAAGGCGATTTTGGTAAACCAAGACCTGCGTTAATCATTCAAGCCAATCA
ATTTAGTGAACATACAAGCGTGATGGTTTTACCAATTACAAGTACACTTATTGATGCACCATTACTCCGTATTACTGTCC
AACCAGACGCTAAAAATGGTTTACAAAAGCCCTCGCAAGTCATGATTGATAAGATTATGACAGTAAGATGTGAAAAAGTT
AGTCCAGCTTTCGGCTTCATTCATGCAGATAAAATGGTAGAAATTGAACGTTGTTTGGCTGTATTTTTAGGAATAGTAAA
ATGA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22343.47 Da
• Isoelectric Point: 5.1445

>AT233503 WP_001251224.1 NZ_CP091525:121150-121749 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Nucleotide

• Length: 600 bp

>AT233503 NZ_HG969191:371069-371293 [Bartonella henselae]
ATGGCTACAATGCACGTCAATGAACGCGTTCAAAAACATCGCAATGCACAAAGAAAAGCAGGTTTGCGTTTAATACAAAT
TTGGGTACCAGATACTCGTCAACCAAACTTTGCAGAAGAGTGTCGACGCCAATGTCGCTTAGTCGCAAAAATGGATAAAA
CAGATACATCTATGCAGTTGTTAATGGATAAATCTTTAATGGATATTGATGGCTGGACAGAATGA

Structures

Toxin

• AlphaFold DB: X5E2E6

Antitoxin

• AlphaFold DB: W8U4V4