233498

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2735931..2736445 Replicon chromosome
Accession NZ_CP091523
Organism Staphylococcus aureus strain N12HSA28

Toxin (Protein)


Gene name TsdT Uniprot ID A0A641A3V2
Locus tag L5471_RS13455 Protein ID WP_000581793.1
Coordinates 2736236..2736445 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag L5471_RS13450 Protein ID WP_000138932.1
Coordinates 2735931..2736224 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L5471_RS13430 (2731393) 2731393..2732034 + 642 WP_000483155.1 thiamine phosphate synthase -
L5471_RS13435 (2732120) 2732120..2732992 + 873 WP_000725802.1 membrane protein insertase YidC -
L5471_RS13440 (2733606) 2733606..2734253 - 648 WP_001187628.1 HD domain-containing protein -
L5471_RS13445 (2734281) 2734281..2735765 - 1485 WP_000571549.1 cardiolipin synthase -
L5471_RS13450 (2735931) 2735931..2736224 + 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
L5471_RS13455 (2736236) 2736236..2736445 + 210 WP_000581793.1 heavy metal-associated domain-containing protein Toxin
L5471_RS13460 (2736573) 2736573..2736710 + 138 WP_000828354.1 Lmo0850 family protein -
L5471_RS13465 (2736973) 2736973..2738175 - 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
L5471_RS13470 (2738493) 2738493..2739563 + 1071 WP_000159627.1 D-alanine--D-alanine ligase -
L5471_RS13475 (2739578) 2739578..2740936 + 1359 WP_000611483.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7809.75 Da        Isoelectric Point: 4.1008

>T233498 WP_000581793.1 NZ_CP091523:2736236-2736445 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVI

Download         Length: 210 bp

>T233498 NZ_HG965802:c810447-810175 [Bartonella henselae]
ATGAAGCTCGTTTGGACACGGATAGCGCATTACGATCGTCAAAAGATACGGGAATATATCGCGCAAGAAAATCCTTCTGC
TGCATTAGTATTCGACAAGCTTTTATCTAAAAAAGTAGAAAGACTCATTAGCTTTCCTAATCTTGGTCGTGTTGGCCGAA
TTAGGAATACGCGCGAGCTTATTGTGCGTAAGAATTATATTATGATTTATGATGTTTCTAATGGCACTATACGGGTTTTG
CGCATACTTCACGCAAAACAAAAGTGGCCATAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT233498 WP_000138932.1 NZ_CP091523:2735931-2736224 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT233498 NZ_HG965802:c810734-810444 [Bartonella henselae]
ATGGCTGAAACAACATTTACCTTTCGCGTTGATGATGCATTAAAAAGTGAATTTTCTCAGGCTGCAAAAGCATGTGATCG
ATCTGCTGCACAGCTCTTACGGGATTACATGCGTGATATTGTAAAAGAACAAAAAGAAAAGATAGCGCATGAATTATGGT
TTCAGGAACAAGTCCAACTTGGATTAAATTCTGCCAACGCAGGTGATGTAATACCTTTTGAAGAAATTGAAACAGAAGCA
CAAGCATGGCGCTTTGAAATACAACGCAAGCTGAAGACATCAGATTCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A641A3V2

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References