Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 120870..121646 Replicon chromosome
Accession NZ_CP091523
Organism Staphylococcus aureus strain N12HSA28

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag L5471_RS00775 Protein ID WP_000031108.1
Coordinates 121494..121646 (+) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID W8U4V4
Locus tag L5471_RS00770 Protein ID WP_001251224.1
Coordinates 120870..121469 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L5471_RS00750 (116786) 116786..118243 + 1458 WP_000649907.1 ABC transporter permease subunit -
L5471_RS00755 (118236) 118236..118958 + 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
L5471_RS00760 (119109) 119109..120236 + 1128 WP_000379987.1 tRNA epoxyqueuosine(34) reductase QueG -
L5471_RS00765 (120241) 120241..120711 + 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
L5471_RS00770 (120870) 120870..121469 + 600 WP_001251224.1 glucosamine-6-phosphate isomerase Antitoxin
L5471_RS00775 (121494) 121494..121646 + 153 WP_000031108.1 SAS053 family protein Toxin
L5471_RS00780 (122252) 122252..122647 + 396 WP_000901023.1 hypothetical protein -
L5471_RS00785 (122843) 122843..124228 + 1386 WP_000116229.1 class II fumarate hydratase -
L5471_RS00790 (124689) 124689..125510 - 822 WP_000669376.1 RluA family pseudouridine synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T233482 WP_000031108.1 NZ_CP091523:121494-121646 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

>T233482 NZ_HG941718:c3991773-3991666 [Escherichia coli O25b:H4-ST131]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22343.47 Da        Isoelectric Point: 5.1445

>AT233482 WP_001251224.1 NZ_CP091523:120870-121469 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp

>AT233482 NZ_HG941718:3991822-3991887 [Escherichia coli O25b:H4-ST131]
GTCTAGATGCAAGAATGGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB W8U4V4

References