Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-parD/RelE(toxin)
Location 2220100..2220788 Replicon chromosome
Accession NZ_CP091522
Organism Neisseria sp. Dent CA1/247

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag LVJ85_RS10970 Protein ID WP_244739842.1
Coordinates 2220513..2220788 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag LVJ85_RS10965 Protein ID WP_199903497.1
Coordinates 2220100..2220387 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ85_RS10945 (LVJ85_10945) 2216113..2216658 - 546 WP_244739838.1 plasmid mobilization relaxosome protein MobC -
LVJ85_RS10950 (LVJ85_10950) 2216727..2218829 - 2103 WP_244739839.1 hypothetical protein -
LVJ85_RS10955 (LVJ85_10955) 2218898..2219719 - 822 WP_244739840.1 hypothetical protein -
LVJ85_RS10960 (LVJ85_10960) 2219844..2220122 - 279 WP_244739841.1 type II toxin-antitoxin system RelE/ParE family toxin -
LVJ85_RS10965 (LVJ85_10965) 2220100..2220387 - 288 WP_199903497.1 hypothetical protein Antitoxin
LVJ85_RS10970 (LVJ85_10970) 2220513..2220788 - 276 WP_244739842.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LVJ85_RS10975 (LVJ85_10975) 2220775..2220975 - 201 WP_244739843.1 hypothetical protein -
LVJ85_RS10980 (LVJ85_10980) 2221089..2224127 - 3039 WP_244739844.1 PriCT-2 domain-containing protein -
LVJ85_RS10985 (LVJ85_10985) 2224229..2224720 - 492 WP_244739845.1 hypothetical protein -
LVJ85_RS10990 (LVJ85_10990) 2224969..2225592 - 624 WP_244739846.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 2195870..2235064 39194


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-85)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10452.00 Da        Isoelectric Point: 5.8742

>T233478 WP_244739842.1 NZ_CP091522:c2220788-2220513 [Neisseria sp. Dent CA1/247]
MHIIEWSAGALSDVDDILDFIFADNPHAAVEMDLLIHDSVQHLSTLPYIGRKGRVADTREYVIHPNYLIIYEVSPNRVKI
LSVLHVRKEYP

Download         Length: 276 bp

>T233478 NZ_HG941718:c3536033-3535719 [Escherichia coli O25b:H4-ST131]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCTTCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTCGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCCGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10885.08 Da        Isoelectric Point: 4.2397

>AT233478 WP_199903497.1 NZ_CP091522:c2220387-2220100 [Neisseria sp. Dent CA1/247]
MAQFIMNVPDAEKEAFMEAARLSDRNASQLVREFMRDFIEKQRYEAYVRAEVEKGLADVAAGRVRSGEEVDREMEALLEQ
WADEERNADAGRVDG

Download         Length: 288 bp

>AT233478 NZ_HG941718:c3535722-3535306 [Escherichia coli O25b:H4-ST131]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTACTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGTGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTTCCGGAAATAGGCAGTAAATCGATGGT
GTCACGCGTTTTGAGCGGGAAAAGGAAATTAACGCTGGAACACGCTAAAAAACTGGCAACGCGATTCGGTATTTCTCCCG
CCTTGTTTATTGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References