233475

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 2144048..2144634 Replicon chromosome
Accession NZ_CP091522
Organism Neisseria sp. Dent CA1/247

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LVJ85_RS10540 Protein ID WP_244739784.1
Coordinates 2144048..2144302 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LVJ85_RS10545 Protein ID WP_244739785.1
Coordinates 2144299..2144634 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ85_RS10510 (LVJ85_10510) 2139896..2140486 - 591 WP_244743183.1 GTP cyclohydrolase II -
LVJ85_RS10515 (LVJ85_10515) 2140479..2141150 - 672 WP_244739780.1 hypothetical protein -
LVJ85_RS10525 (LVJ85_10525) 2141619..2142821 + 1203 WP_244739781.1 tyrosine-type recombinase/integrase -
LVJ85_RS10530 (LVJ85_10530) 2142844..2143020 + 177 WP_244739782.1 hypothetical protein -
LVJ85_RS10535 (LVJ85_10535) 2143152..2143457 + 306 WP_244739783.1 hypothetical protein -
LVJ85_RS13365 2143867..2143995 - 129 WP_255733767.1 hypothetical protein -
LVJ85_RS10540 (LVJ85_10540) 2144048..2144302 + 255 WP_244739784.1 type II toxin-antitoxin system HicA family toxin Toxin
LVJ85_RS10545 (LVJ85_10545) 2144299..2144634 + 336 WP_244739785.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LVJ85_RS10550 (LVJ85_10550) 2145129..2146205 + 1077 WP_244739786.1 ATP-binding protein -
LVJ85_RS10555 (LVJ85_10555) 2146530..2148008 - 1479 WP_244739787.1 4-hydroxy-3-polyprenylbenzoate decarboxylase -
LVJ85_RS10565 (LVJ85_10565) 2148477..2148659 - 183 WP_085364438.1 DNA gyrase inhibitor YacG -
LVJ85_RS10570 (LVJ85_10570) 2148663..2149433 - 771 WP_244739788.1 cell division protein ZapD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(23-75)

Antitoxin

Uncharacterised protein family HicB

(55-105)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9418.92 Da        Isoelectric Point: 10.5624

>T233475 WP_244739784.1 NZ_CP091522:2144048-2144302 [Neisseria sp. Dent CA1/247]
MKKKHQRTLALIFSRPVSGSIKWADIEALFVELGAEIQEREGSRVAVILFGQVKVFHRPHPSPDTDKGAVASVRKWLEEN
GVKP

Download         Length: 255 bp

>T233475 NZ_HG941718:c3212428-3212021 [Escherichia coli O25b:H4-ST131]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATTCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGAAAACGGCA
ACATTTATGGCTGGCAGCTGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12017.42 Da        Isoelectric Point: 5.0956

>AT233475 WP_244739785.1 NZ_CP091522:2144299-2144634 [Neisseria sp. Dent CA1/247]
MNNVMEINGHKAIIQYDPETELLRGEFVGLNGGADFYADNVADLHKEGVASLAVFLDVCKEKGIEPYKQYSGRFNVRVSP
ETHAAAAAAAAAQNISLNEWVNRAISQSAHA

Download         Length: 336 bp

>AT233475 NZ_HG941718:c3212675-3212409 [Escherichia coli O25b:H4-ST131]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCACCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCAGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References