Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2748269..2748903 Replicon chromosome
Accession NZ_CP091519
Organism Alysiella crassa strain S6

Toxin (Protein)


Gene name vapC Uniprot ID A0A376BMZ6
Locus tag LVJ80_RS14240 Protein ID WP_034294258.1
Coordinates 2748269..2748661 (-) Length 131 a.a.

Antitoxin (Protein)


Gene name VapB1 Uniprot ID A0A376BN38
Locus tag LVJ80_RS14245 Protein ID WP_034294260.1
Coordinates 2748658..2748903 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ80_RS14205 (LVJ80_14205) 2743913..2745160 - 1248 WP_051968568.1 ATP-binding protein -
LVJ80_RS14210 (LVJ80_14210) 2745224..2746153 + 930 WP_034294252.1 alpha/beta hydrolase -
LVJ80_RS14215 (LVJ80_14215) 2746315..2746731 + 417 WP_034294254.1 MarR family transcriptional regulator -
LVJ80_RS14220 (LVJ80_14220) 2746857..2747288 + 432 WP_034294256.1 organic hydroperoxide resistance protein -
LVJ80_RS14225 (LVJ80_14225) 2747371..2747703 - 333 WP_244773164.1 LysR substrate-binding domain-containing protein -
LVJ80_RS14230 (LVJ80_14230) 2747700..2747945 - 246 WP_211249442.1 hypothetical protein -
LVJ80_RS14235 (LVJ80_14235) 2747999..2748250 - 252 WP_211249443.1 LysR family transcriptional regulator -
LVJ80_RS14240 (LVJ80_14240) 2748269..2748661 - 393 WP_034294258.1 type II toxin-antitoxin system VapC family toxin Toxin
LVJ80_RS14245 (LVJ80_14245) 2748658..2748903 - 246 WP_034294260.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LVJ80_RS14250 (LVJ80_14250) 2749110..2750207 + 1098 WP_084693573.1 alpha/beta hydrolase -
LVJ80_RS14255 (LVJ80_14255) 2750285..2751367 - 1083 WP_115723633.1 IS4 family transposase -
LVJ80_RS14260 (LVJ80_14260) 2751427..2752389 - 963 WP_051968641.1 LysR family transcriptional regulator -
LVJ80_RS14265 (LVJ80_14265) 2752684..2753532 + 849 WP_034295772.1 MBL fold metallo-hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-122)

Antitoxin

SpoVT-AbrB domain

(8-45)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14828.12 Da        Isoelectric Point: 9.3848

>T233473 WP_034294258.1 NZ_CP091519:c2748661-2748269 [Alysiella crassa]
MKYLLDTNIIIAFQKQHQGLLAQMKKHSVSDFALSNIVLFELAFGAYNSQKVDENLHKLSRLRFPTLPFNSQDAYHAGKI
RATLQQKGTPIGAYDTLIAGQAIAQNLILITHNIKEFQRVDDLKFEDWLI

Download         Length: 393 bp

>T233473 NZ_HG941718:c2289388-2289134 [Escherichia coli O25b:H4-ST131]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAGCAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAACCAGAACCCCTGAAACATAACTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCTTCTGGTATACGCGGTTACTGATGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9610.80 Da        Isoelectric Point: 4.1844

>AT233473 WP_034294260.1 NZ_CP091519:c2748903-2748658 [Alysiella crassa]
MTATAKLFWTGNSQAVRLPKEFRFEGKEVRIFKQGNQVIIEPIVDDWDWVNDLEPFDDTMEHAILELKNDVPQERDWSVF
E

Download         Length: 246 bp

>AT233473 NZ_HG941718:c2289636-2289385 [Escherichia coli O25b:H4-ST131]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGACAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A376BMZ6

Antitoxin

Source ID Structure
AlphaFold DB A0A376BN38

References