Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1262568..1263217 Replicon chromosome
Accession NZ_CP091519
Organism Alysiella crassa strain S6

Toxin (Protein)


Gene name VapC1 Uniprot ID A0A376BTC3
Locus tag LVJ80_RS06555 Protein ID WP_034293024.1
Coordinates 1262568..1262978 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name VapB1 Uniprot ID A0A376BSY3
Locus tag LVJ80_RS06560 Protein ID WP_034293021.1
Coordinates 1262975..1263217 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ80_RS06530 (LVJ80_06530) 1258240..1259046 + 807 WP_034293034.1 RNA methyltransferase -
LVJ80_RS06535 (LVJ80_06535) 1259189..1260337 + 1149 WP_034293032.1 DUF4349 domain-containing protein -
LVJ80_RS06540 (LVJ80_06540) 1260436..1260960 + 525 WP_034293030.1 DNA-3-methyladenine glycosylase I -
LVJ80_RS06545 (LVJ80_06545) 1261029..1261208 - 180 WP_034293028.1 hypothetical protein -
LVJ80_RS06550 (LVJ80_06550) 1261321..1262541 - 1221 WP_034293026.1 exodeoxyribonuclease VII large subunit -
LVJ80_RS06555 (LVJ80_06555) 1262568..1262978 - 411 WP_034293024.1 PIN domain-containing protein Toxin
LVJ80_RS06560 (LVJ80_06560) 1262975..1263217 - 243 WP_034293021.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
LVJ80_RS06565 (LVJ80_06565) 1263336..1264793 + 1458 WP_244773635.1 potassium transporter TrkG -
LVJ80_RS15345 1265072..1265206 - 135 WP_280517570.1 hypothetical protein -
LVJ80_RS06570 (LVJ80_06570) 1265251..1266958 + 1708 Protein_1307 proline--tRNA ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-116)

Antitoxin

SpoVT-AbrB domain

(6-44)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 15426.96 Da        Isoelectric Point: 9.3946

>T233471 WP_034293024.1 NZ_CP091519:c1262978-1262568 [Alysiella crassa]
MIYLLDTNMIVYLMRNRPEIVARKIASLPRHDKVCMSFITYSELLKGVYRSELSEKSKHKLELLAKHIDVLLPREAISEH
YARLGAQLKQQGTPIGNNDLWIAAHARSLGAVLVSNQSQIFQNISGLIIEDWTQAA

Download         Length: 411 bp

>T233471 NZ_HG941718:c1976414-1976312 [Escherichia coli O25b:H4-ST131]
GCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9162.22 Da        Isoelectric Point: 4.2336

>AT233471 WP_034293021.1 NZ_CP091519:c1263217-1262975 [Alysiella crassa]
MLTRVFQSGNSQAVRIPISFRFKVDTVEILHGDNGDVILRPIQPDTRGEDFLALFEGFDEDFIRAVEERDNTPPQERDAL

Download         Length: 243 bp

>AT233471 NZ_HG941718:1976274-1976542 [Escherichia coli O25b:H4-ST131]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCTCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTTAAATATTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A376BTC3

Antitoxin

Source ID Structure
AlphaFold DB A0A376BSY3

References