Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbE-relB/ParE-YafN
Location 1184836..1185353 Replicon chromosome
Accession NZ_CP091518
Organism Kingella kingae strain 4177/66

Toxin (Protein)


Gene name stbE Uniprot ID -
Locus tag LVJ79_RS06215 Protein ID WP_026036330.1
Coordinates 1184836..1185114 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag LVJ79_RS06220 Protein ID WP_026036329.1
Coordinates 1185111..1185353 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ79_RS06195 (LVJ79_06195) 1180185..1182044 - 1860 WP_003786741.1 FAD-dependent oxidoreductase -
LVJ79_RS06200 (LVJ79_06200) 1182381..1182689 + 309 WP_003786737.1 Grx4 family monothiol glutaredoxin -
LVJ79_RS06205 (LVJ79_06205) 1183019..1184377 - 1359 WP_003786735.1 PFL family protein -
LVJ79_RS06210 (LVJ79_06210) 1184422..1184784 - 363 WP_003786733.1 hypothetical protein -
LVJ79_RS06215 (LVJ79_06215) 1184836..1185114 - 279 WP_026036330.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LVJ79_RS06220 (LVJ79_06220) 1185111..1185353 - 243 WP_026036329.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
LVJ79_RS06225 (LVJ79_06225) 1185433..1187124 - 1692 WP_003786726.1 D-lactate dehydrogenase -
LVJ79_RS06230 (LVJ79_06230) 1187151..1187423 - 273 WP_032133449.1 ACT domain-containing protein -
LVJ79_RS06235 (LVJ79_06235) 1187485..1188645 - 1161 WP_003786722.1 radical SAM family heme chaperone HemW -
LVJ79_RS06240 (LVJ79_06240) 1188627..1189175 - 549 WP_032827709.1 DNA-3-methyladenine glycosylase I -
LVJ79_RS06245 (LVJ79_06245) 1189175..1189555 - 381 WP_003786719.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-81)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(10-72)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10709.42 Da        Isoelectric Point: 10.2595

>T233467 WP_026036330.1 NZ_CP091518:c1185114-1184836 [Kingella kingae]
INYRFVAEAEDEWRKLDNSIKQQFKSALAKRLENPRIPSAALHNMPDCYKIKLRKIGYRLVYRVDDNVLTVTVIAIGKRD
KSVVYDVANSRL

Download         Length: 279 bp

>T233467 NZ_HG941718:c509511-509293 [Escherichia coli O25b:H4-ST131]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9019.12 Da        Isoelectric Point: 4.0466

>AT233467 WP_026036329.1 NZ_CP091518:c1185353-1185111 [Kingella kingae]
MQAVLADYAVSVAELKRNYASIIDEATGAVAVLNHNKLEAYLIPAQHYEQLMDYLEDLQDAQIIQERINSPSREVSLDEL

Download         Length: 243 bp

>AT233467 NZ_HG941718:c509911-509537 [Escherichia coli O25b:H4-ST131]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References