Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/HicA-HicB |
| Location | 18483..19129 | Replicon | plasmid p1Npotu |
| Accession | NZ_CP091517 | ||
| Organism | Kingella potus strain 3/SID/1128 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | - |
| Locus tag | LVJ84_RS14420 | Protein ID | WP_115307217.1 |
| Coordinates | 18944..19129 (-) | Length | 62 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | - |
| Locus tag | LVJ84_RS14415 | Protein ID | WP_115307216.1 |
| Coordinates | 18483..18890 (-) | Length | 136 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LVJ84_RS14370 (LVJ84_14370) | 13961..14188 | + | 228 | WP_244733679.1 | hypothetical protein | - |
| LVJ84_RS14375 (LVJ84_14375) | 14303..14677 | + | 375 | WP_115307209.1 | hypothetical protein | - |
| LVJ84_RS14380 (LVJ84_14380) | 14674..14943 | + | 270 | WP_244733680.1 | hypothetical protein | - |
| LVJ84_RS14385 (LVJ84_14385) | 14889..15059 | - | 171 | WP_244733681.1 | hypothetical protein | - |
| LVJ84_RS14390 (LVJ84_14390) | 15178..15990 | - | 813 | WP_147286535.1 | KilA-N domain-containing protein | - |
| LVJ84_RS14395 (LVJ84_14395) | 16610..16822 | + | 213 | WP_115307212.1 | hypothetical protein | - |
| LVJ84_RS14400 (LVJ84_14400) | 16975..17355 | - | 381 | WP_115307213.1 | type II toxin-antitoxin system PemK/MazF family toxin | - |
| LVJ84_RS14405 (LVJ84_14405) | 17777..17989 | + | 213 | WP_115307214.1 | hypothetical protein | - |
| LVJ84_RS14410 (LVJ84_14410) | 18026..18496 | + | 471 | WP_115307215.1 | lysozyme | - |
| LVJ84_RS14415 (LVJ84_14415) | 18483..18890 | - | 408 | WP_115307216.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| LVJ84_RS14420 (LVJ84_14420) | 18944..19129 | - | 186 | WP_115307217.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| LVJ84_RS14425 (LVJ84_14425) | 19217..19549 | + | 333 | WP_115307218.1 | hypothetical protein | - |
| LVJ84_RS14430 (LVJ84_14430) | 19494..19700 | + | 207 | WP_244733685.1 | hypothetical protein | - |
| LVJ84_RS14435 (LVJ84_14435) | 19712..20701 | - | 990 | WP_115307219.1 | site-specific integrase | - |
| LVJ84_RS15170 | 20953..21081 | - | 129 | WP_280529822.1 | hypothetical protein | - |
| LVJ84_RS14440 (LVJ84_14440) | 21143..21361 | - | 219 | WP_115308905.1 | hypothetical protein | - |
| LVJ84_RS14445 (LVJ84_14445) | 21358..21534 | - | 177 | WP_172461249.1 | hypothetical protein | - |
| LVJ84_RS14450 (LVJ84_14450) | 21551..21910 | - | 360 | WP_115308906.1 | hypothetical protein | - |
| LVJ84_RS14455 (LVJ84_14455) | 21914..22159 | - | 246 | WP_115308907.1 | flagellar protein required for flagellar formation | - |
| LVJ84_RS14460 (LVJ84_14460) | 22125..22592 | - | 468 | WP_244733682.1 | hypothetical protein | - |
| LVJ84_RS14465 (LVJ84_14465) | 22535..22846 | - | 312 | WP_244733684.1 | hypothetical protein | - |
| LVJ84_RS14470 (LVJ84_14470) | 22923..23537 | - | 615 | WP_115308909.1 | YqaJ viral recombinase family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..48812 | 48812 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 62 a.a. Molecular weight: 6803.93 Da Isoelectric Point: 10.4950
>T233464 WP_115307217.1 NZ_CP091517:c19129-18944 [Kingella potus]
MKSRELIAILEAGGWQLVRVKGSHHQFKKDGVPHLITISHPEKDVSLGQLKDAKKKSGLDF
MKSRELIAILEAGGWQLVRVKGSHHQFKKDGVPHLITISHPEKDVSLGQLKDAKKKSGLDF
Download Length: 186 bp
>T233464 NZ_HG939456:c1859491-1859237 [Streptococcus agalactiae COH1]
ATGTTTAATTTTACTGAAGAAGCATGGAAAGATTATGTTTCTTGGCAACAGGAAGATAAAAAAATCTTGAAACGAATTAA
TCGTTTGATAGAAGATATTAAAAGAGACCCATTTGAAGGCATTGGAAAACCAGAACCTTTAAAATACCATTATTCAGGGG
CTTGGTCTCGAAGAATTACAGAAGAACATAGGTTGATTTATATGATAGAAGATGGAGAAATCTATTTTTTATCTTTTAGA
GATCATTATAAGTAG
ATGTTTAATTTTACTGAAGAAGCATGGAAAGATTATGTTTCTTGGCAACAGGAAGATAAAAAAATCTTGAAACGAATTAA
TCGTTTGATAGAAGATATTAAAAGAGACCCATTTGAAGGCATTGGAAAACCAGAACCTTTAAAATACCATTATTCAGGGG
CTTGGTCTCGAAGAATTACAGAAGAACATAGGTTGATTTATATGATAGAAGATGGAGAAATCTATTTTTTATCTTTTAGA
GATCATTATAAGTAG
Antitoxin
Download Length: 136 a.a. Molecular weight: 14900.80 Da Isoelectric Point: 4.1955
>AT233464 WP_115307216.1 NZ_CP091517:c18890-18483 [Kingella potus]
MIYYPAALFQDAGQSGYGIVIPDLPGCYPVGDTVEEALADAKAAAAFHIEGMIAESLEYVTAPRGIAELRSLPDYADALM
WVLVEVDETVFSKQTRFNVSWPQYLLDRVDEYTAIHHETRSGFLARAALDALNRS
MIYYPAALFQDAGQSGYGIVIPDLPGCYPVGDTVEEALADAKAAAAFHIEGMIAESLEYVTAPRGIAELRSLPDYADALM
WVLVEVDETVFSKQTRFNVSWPQYLLDRVDEYTAIHHETRSGFLARAALDALNRS
Download Length: 408 bp
>AT233464 NZ_HG939456:c1859750-1859484 [Streptococcus agalactiae COH1]
ATGGAGGCTATTGTTTATTCACATTTTAGAAATAATTTAAAAGATTATATGAAGAAGGTCAATGATGAATTTGAGCCTTT
GATTGTAGTTAATAAAAATCCTGATGAAAATATAGTGGTTTTATCTCAAGATAGCTGGGAAAGTTTACAAGAAACGATTC
GTTTGATGGAAAATGATTATCTATCACATAAGGTTATTAATGGTATATCACAAGTTAAAGAGAAGCAAGTCACTAAACAT
GGTTTAATTGAGGTAGAAGATGTTTAA
ATGGAGGCTATTGTTTATTCACATTTTAGAAATAATTTAAAAGATTATATGAAGAAGGTCAATGATGAATTTGAGCCTTT
GATTGTAGTTAATAAAAATCCTGATGAAAATATAGTGGTTTTATCTCAAGATAGCTGGGAAAGTTTACAAGAAACGATTC
GTTTGATGGAAAATGATTATCTATCACATAAGGTTATTAATGGTATATCACAAGTTAAAGAGAAGCAAGTCACTAAACAT
GGTTTAATTGAGGTAGAAGATGTTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|