Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1998331..1998977 Replicon chromosome
Accession NZ_CP091516
Organism Kingella potus strain 3/SID/1128

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LVJ84_RS11810 Protein ID WP_115307217.1
Coordinates 1998331..1998516 (+) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LVJ84_RS11815 Protein ID WP_115307216.1
Coordinates 1998570..1998977 (+) Length 136 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ84_RS11765 (LVJ84_11765) 1993831..1994571 + 741 WP_244731555.1 pimeloyl-ACP methyl ester esterase BioH -
LVJ84_RS11770 (LVJ84_11770) 1994659..1995174 + 516 WP_115308342.1 hypothetical protein -
LVJ84_RS11775 (LVJ84_11775) 1995256..1995417 + 162 Protein_2338 Rieske 2Fe-2S domain-containing protein -
LVJ84_RS11780 (LVJ84_11780) 1995505..1995777 - 273 WP_244733532.1 hypothetical protein -
LVJ84_RS11785 (LVJ84_11785) 1995801..1996205 + 405 WP_244733533.1 hypothetical protein -
LVJ84_RS11790 (LVJ84_11790) 1996461..1996661 + 201 WP_244731556.1 hypothetical protein -
LVJ84_RS15055 1997355..1997405 + 51 Protein_2342 hypothetical protein -
LVJ84_RS15060 1997452..1997748 + 297 WP_280529816.1 tyrosine-type recombinase/integrase -
LVJ84_RS11800 (LVJ84_11800) 1997760..1997897 - 138 WP_244733542.1 hypothetical protein -
LVJ84_RS11805 (LVJ84_11805) 1997911..1998243 - 333 WP_115307218.1 hypothetical protein -
LVJ84_RS11810 (LVJ84_11810) 1998331..1998516 + 186 WP_115307217.1 type II toxin-antitoxin system HicA family toxin Toxin
LVJ84_RS11815 (LVJ84_11815) 1998570..1998977 + 408 WP_115307216.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LVJ84_RS11820 (LVJ84_11820) 1998964..1999434 - 471 WP_115307215.1 lysozyme -
LVJ84_RS11825 (LVJ84_11825) 1999471..1999683 - 213 WP_115308340.1 hypothetical protein -
LVJ84_RS11830 (LVJ84_11830) 2000312..2001157 + 846 WP_244731558.1 Rha family transcriptional regulator -
LVJ84_RS11835 (LVJ84_11835) 2001660..2002154 - 495 WP_244731559.1 hypothetical protein -
LVJ84_RS11840 (LVJ84_11840) 2002151..2002378 - 228 WP_244731560.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1991842..2041659 49817


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-128)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6803.93 Da        Isoelectric Point: 10.4950

>T233463 WP_115307217.1 NZ_CP091516:1998331-1998516 [Kingella potus]
MKSRELIAILEAGGWQLVRVKGSHHQFKKDGVPHLITISHPEKDVSLGQLKDAKKKSGLDF

Download         Length: 186 bp

>T233463 NZ_HG938371:2354408-2354989 [Burkholderia cenocepacia H111]
ATGAATCCCGATACGATCCGCGCGCGCCTCGATTTCCTGCGCGACGCCGAACGCCTGAAAGACGTGCTGCGCAGCGGCCA
CACGTCGGCCGGGCGCGCGGAAAGCACGGCCGAGCATAGCTGGCGGCTGTGCCTGATGGCGCTCGTGTTCGCCGACGCGC
TGCCCGGCGTCGATACGCTGAAGCTGCTGAAACTGTGCGTCGTCCACGACCTCGGCGAGGCGCTGCACGGCGACATCCCC
GCGATCGAGCAGGCCGCGCATCCCGACAAGAGCGCGCACGAACGCGACGATCTGCTGACGCTGACCGCGTCGCTCGACCG
CGCGGCGCGCGACGAGATCGTCGCGCTGTGGGACGAATACGAGGCAGCCACCTCGCCGGAAGCCCGCGCGGCGAAGGCGC
TCGACAAGCTGGAAACGATCCTGCAGCACAACCAGGGCAGCAATCCGCCCGATTTCGACTATGCGTTCAATCTCGGCTAC
GGCCGGCGCTATACCGATGCCGCGCCGCTGTTCAGCGCGATCCGCGAGATCGTCGATGTCGACACGCAGCGCAGGATCGA
CGCGGGTGGGCAGCGCGCGTAA

Antitoxin


Download         Length: 136 a.a.        Molecular weight: 14900.80 Da        Isoelectric Point: 4.1955

>AT233463 WP_115307216.1 NZ_CP091516:1998570-1998977 [Kingella potus]
MIYYPAALFQDAGQSGYGIVIPDLPGCYPVGDTVEEALADAKAAAAFHIEGMIAESLEYVTAPRGIAELRSLPDYADALM
WVLVEVDETVFSKQTRFNVSWPQYLLDRVDEYTAIHHETRSGFLARAALDALNRS

Download         Length: 408 bp

>AT233463 NZ_HG938371:2353763-2354329 [Burkholderia cenocepacia H111]
ATGCCCCACCCGCCGCTTCATCCATCCTCGCTCGGCCCGCAACTCAAGCGCTGGCGCGCGCTGCACCGCGTAAAGCAAAG
CCATGCAGCCGAACTGTTCCGCGTCGCGCAATCGACGATCTCCCGCTGGGAAGCCGGCCTTCAGCAGATGTCGCCCGCCG
AGCGCGCGACGGCCGAACGGCTGCTCGCCGCGCGCCTCGATTCCGCGGGCGACCACGCGCTCGCGCGGCTGATCGCCGGC
AGCACGGGCCGCATGCATCTCGTGTGCGACCTCACGCACCGCCTGCTGGCCAGCTCGCCGGCGCGCGCGGCCGAGTTCTC
GCGGCCGCTTTCGACGCTGCTCGGCGCGTCGCTGTGGCGCTATGCGACGCCGGAAATCGCCCGCATGGAAGCCGCGCTCG
ACCCGCTCGGCTGGTACGACCGCGCGGGACCGCCGAGCGTCGAGTTCGACACGGGCGCGAACGCGTCGCGCGTCGTGCCG
ATTCGCGGCAGCCTGTGCCGATGGACGCGGATGACGCTGTCGGACGGCTCGGCCGTGCGGCTCGTGGAAACGCTGGACGC
GCACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References