Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 1211820..1212415 Replicon chromosome
Accession NZ_CP091516
Organism Kingella potus strain 3/SID/1128

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag LVJ84_RS07050 Protein ID WP_115309004.1
Coordinates 1211820..1212119 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag LVJ84_RS07055 Protein ID WP_115309005.1
Coordinates 1212116..1212415 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ84_RS07035 (LVJ84_07035) 1208224..1209405 + 1182 WP_115309001.1 integrase arm-type DNA-binding domain-containing protein -
LVJ84_RS07040 (LVJ84_07040) 1209589..1210668 + 1080 WP_115309002.1 ATP-binding protein -
LVJ84_RS07045 (LVJ84_07045) 1210932..1211213 + 282 WP_115309003.1 hypothetical protein -
LVJ84_RS07050 (LVJ84_07050) 1211820..1212119 + 300 WP_115309004.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LVJ84_RS07055 (LVJ84_07055) 1212116..1212415 + 300 WP_115309005.1 putative addiction module antidote protein Antitoxin
LVJ84_RS07060 (LVJ84_07060) 1212519..1213172 - 654 WP_115307381.1 IS1595 family transposase -
LVJ84_RS07065 (LVJ84_07065) 1213724..1214407 - 684 WP_244731284.1 lysozyme inhibitor LprI family protein -
LVJ84_RS07070 (LVJ84_07070) 1214458..1214709 - 252 WP_244731285.1 hypothetical protein -
LVJ84_RS07075 (LVJ84_07075) 1214925..1216256 - 1332 WP_115309007.1 sodium/glutamate symporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1212519..1213172 653


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-92)

Antitoxin

Uncharacterized protein HI1420

(2-97)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11208.78 Da        Isoelectric Point: 9.8318

>T233462 WP_115309004.1 NZ_CP091516:1211820-1212119 [Kingella potus]
MRYIIETTAHFDEWFDGLRDLRAKAKVITRLERIEAGNLGDHKAIGGGLSEIRINEGKGYRLYYTIRGNTVIFMLAGGNK
STQQADIARARQLKEDLNP

Download         Length: 300 bp

>T233462 NZ_HG938371:c2070881-2070369 [Burkholderia cenocepacia H111]
ATGATCCCTGTCGATACGAACGTCATGCCCGAACCGCTGCGGCGTGAGCCGAACGCGGCGGTGATCGAGTGGCTCGATGC
GCAGAACGTCGAGACGCTGTATCTCGCGGCGATCGGTCTCGCGGAATTGCGGTTCGGCGTGGCTGCATTGCGGGAAGGGC
GCAGGCGGGATTGGCTGCAGCAGAGTATCGGGCAGCGTGTGCTGTCGCTGTTTCGCGGTCGGATCCTGCCGTTCGACGAC
GCGGCGAGCAGGGCGTACGCGAGCTTTTGCGCGCGGACGCGTGCCGCGGGCAACGCGATCGCGGTCGCCGATGGCTACAT
CGCCGCGACGGCCGAGGCAAACGGCTCGATCGTGGCCACACGCGACGTCGCGCCGTTCCAGGCGTTGGGGCTGCGCATCA
TCGATCCATGGGCCGTCCGGTTCGCGATCGCCGGTTCTTTTGGCGTGCCGAAATGCAAAACGCGCCGTGCGTGGCGGCGC
GTTTTGAATCGAACCATCAGGCTCGTTCCCTGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10707.40 Da        Isoelectric Point: 8.4394

>AT233462 WP_115309005.1 NZ_CP091516:1212116-1212415 [Kingella potus]
MTKTIPFDPARYLKNEEEIAVYLEVAAEEAAEAGDNSILLRAINTAAKARGMMEIAKQAGVSRESLYKSLAPNAKPRFDT
IVKVLDALGVQIKISAKTA

Download         Length: 300 bp

>AT233462 NZ_HG938371:c2071111-2070878 [Burkholderia cenocepacia H111]
GTGATCACCGTTCGAAATTTGCCCGATGAAGTGCACCGCGCGCTTCGGATCGGCGCGGCCCGACACGGGCGCAGTACGGA
AGCGGAGGTGCGCGACATCCTGGAGCAGGCCGTTCTGCCGGGCGGGCGGCTCGAGCTCGGAACGCTGCTCGCGGAAATCG
GGCGGGAAGCGGGCGATGTCGATATCGGCGTGCTGTGCGACGAGATGCCAACCGGTCCGATGAGCTTTGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References