Detailed information of TA system TA233461

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicB(antitoxin)
• Location: 346692..347458
• Replicon: chromosome
• Accession: NZ_CP091515
• Organism: Snodgrassella alvi wkB2

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: X2H9L8
• Locus tag: LVJ87_RS01650
• Protein ID: WP_025330116.1
• Coordinates: 346692..346865 (+)
• Length: 58 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: LVJ87_RS01655
• Protein ID: WP_237749812.1
• Coordinates: 346976..347458 (+)
• Length: 161 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LVJ87_RS01620 (LVJ87_01620)	341911..343464	-	1554	WP_025330122.1	DUF1073 domain-containing protein	-
LVJ87_RS01625 (LVJ87_01625)	343461..344804	-	1344	WP_025330121.1	PBSX family phage terminase large subunit	-
LVJ87_RS01630 (LVJ87_01630)	344797..345345	-	549	WP_198209771.1	terminase small subunit	-
LVJ87_RS01635 (LVJ87_01635)	345531..345713	+	183	WP_025330119.1	type II toxin-antitoxin system HicA family toxin	-
LVJ87_RS01640 (LVJ87_01640)	345745..346170	+	426	WP_025330118.1	type II toxin-antitoxin system HicB family antitoxin	-
LVJ87_RS01645 (LVJ87_01645)	346167..346415	+	249	WP_025330117.1	helix-turn-helix transcriptional regulator	-
LVJ87_RS01650 (LVJ87_01650)	346692..346865	+	174	WP_025330116.1	type II toxin-antitoxin system HicA family toxin	Toxin
LVJ87_RS01655 (LVJ87_01655)	346976..347458	+	483	WP_237749812.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
LVJ87_RS01660 (LVJ87_01660)	347621..348121	-	501	WP_038648687.1	hypothetical protein	-
LVJ87_RS01665 (LVJ87_01665)	348132..348425	-	294	WP_025330113.1	DUF1364 domain-containing protein	-
LVJ87_RS01670 (LVJ87_01670)	348428..349027	-	600	WP_025330112.1	DUF1367 family protein	-
LVJ87_RS01675 (LVJ87_01675)	349030..349377	-	348	WP_025330111.1	hypothetical protein	-
LVJ87_RS01680 (LVJ87_01680)	349307..349660	-	354	WP_025330110.1	hypothetical protein	-
LVJ87_RS01685 (LVJ87_01685)	349650..350165	-	516	WP_025330109.1	DNA N-6-adenine-methyltransferase	-
LVJ87_RS01690 (LVJ87_01690)	350162..350419	-	258	WP_144353315.1	hypothetical protein	-
LVJ87_RS01695 (LVJ87_01695)	350434..350853	-	420	WP_237749811.1	hypothetical protein	-
LVJ87_RS01700 (LVJ87_01700)	350863..350928	-	66	Protein_334	hypothetical protein	-
LVJ87_RS01705 (LVJ87_01705)	351375..352097	+	723	WP_025330106.1	S24 family peptidase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	310324..370571	60247

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (6-57)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (20-81)

Sequences

Toxin

Protein

• Length: 58 a.a.
• Molecular weight: 6614.98 Da
• Isoelectric Point: 11.1168

>T233461 WP_025330116.1 NZ_CP091515:346692-346865 [Snodgrassella alvi wkB2]
MKIQKFLNLLISQGVKTKDGTKHIKLYYNGKQSTLPRHPSKEIPKRLVEKIKKQLGL

Nucleotide

• Length: 174 bp

>T233461 NZ_HG938371:c1951342-1950446 [Burkholderia cenocepacia H111]
ATGAGTGTCATCGACAAACGTGAACGCGACCGCACCGCGGCGTTCGCCGCGCTGCTCGGGCAGTTTCCCGAGCAGCGTTG
CGCGGCCGGCGCGGCGGGCACGATCGGTTATCGCGAGGCCGGCGCGCAGCATGCGGGCCGCGCGCTGCCCGTCGTGCTGC
TGCACGGGATCGGCTCGGGCGCCGCGTCGTGGGTCCGCCAGCTCGACACGCTGGGCGCATCGCGGCGCGTGCTCGCGTGG
GATGCGCCCGGTTACGGCGTGTCGACGCCCGTGCACGGCGCGTCGCCGGCCGCCGCCGATTACGCGGCAGCGCTGAACGC
GTGGCTCGAGGCACTCGGCATCGAACGCTGCGTCCTGGTCGGCCATTCGCTCGGCGCGATCATCGCGGGCGGTCTCGCCC
GCGTGACGCCCGCGCGGATCGCCGGCCTGCTGCTGGTGTCGCCCGCGGGCGGCTACGGCAGCGCACCGGCCGAGACCCGC
GAAGCGCGCCGCGACGCGCGGCTCGCGATGCTCGCGGAACTCGGCCCGGCCGGGCTCGCCGAGCAGCGCAGCGGCAACAT
GCTGTCCGGTTTCGCGAACGAGGAGGCGAAGGCATGGGTGCGCTGGAACATGGCGCGCATCGTGCCGGCCGGCTATGCGC
AGGCCACGCATCTGCTCGCGAACGCCGATCTCGCGGCCGATCTCGCCGGCTTCCGGGGCCGCACGGCCGTGGCCGTCGGC
GCGAACGACGCGATCACGCCGCCCGCCGCGTGCGAGCGGATCGCCGCGGCCGCGCACGTCGGGCTGCAGGTGATTCCGCA
GGCAGGGCACGCCGGCTATGTGGAAGCGCCGGCCGCGTATTCCGCGCTGATCGACTCGTTCTGCCGGCAGTGCGATACGC
AGTGGGGGCTGGCATGA

Antitoxin

Protein

• Length: 161 a.a.
• Molecular weight: 17931.74 Da
• Isoelectric Point: 7.3219

>AT233461 WP_237749812.1 NZ_CP091515:346976-347458 [Snodgrassella alvi wkB2]
MVQISEMYSQNTSCKTDMSYSALIQKQANSYVVTFRDLPEALTCGDTLEEARIMAADALLTALEFYFEDRRPVPIPSKMQ
KGEELISLPPSVTAKVLLLNEMIKQNVSNAELARRLLTRPQDVQRLTNLRHATKIDAINAALNQLGKQLHISLIPIHHSA

Nucleotide

• Length: 483 bp

>AT233461 NZ_HG938371:c1950408-1949551 [Burkholderia cenocepacia H111]
ATGAGCGAACCGCTGCAACAAAACGAATCCGAAAACGCGAAGGCCGAAGCCAGCTACGTGGTGCCGGGCCTCGAACGCGG
GTTGCGGATTCTCGCCGAATTCTCGCCGCGCGAGCCCGTGCTCGGCGCGCCCGAACTGTCGAAGCGGCTCGGCATTCCGC
GCACGACGGTGTTCCGTCTGCTGCAGACGCTCGAATCGCTCGGCTTTCTCGAACGCGCGGACAAGGATCGCAACTACAAG
CTCGGCATCGCGGTGCTGCGGCTCGGCTTCGAATACCTGAGCTCGCTGGAGCTGACCGATCTCGGCCTGCCGGTGATCGA
AAGCCTGCGCGATGCGACCGGCTTCACGACGCACATCGTGATCCGCGACGGCCGCGACGTGGTGTTCGTCGCGAAGGCGC
AGAGCCAGTCGCCGGTGTTCAGTTCGATCCGCGTGAACGTCGGCACCCGGCTGCCCGCGCATGCAACGACACACGGCCAC
GTGCTGATGGGCGACCTGTCGCTGAAGGAACTGCATGCGCTGTATCCGGAAGGCGTGCTGAACCGGATGACGAGCGCGAC
GCCGGAAACGGTCGACGCGCTGTACGAAGTGATCCGCGAGGATGCGCTGCGCGGCTACGGCGTCAGCAATTCGTCGTTCG
AGCGCGGGATCTCGGTCGTCACGGCGCCGGTGCGCAACGAGACGCAGAAGATCGTCGCTTGCATCACGGTGACGGTGCCG
CGTCCGGAGATCGACGCGGCGCTGATCGCGGACGGGCTGATCGACAAGGTGCAGCGCGCGGCGGCGGAACTGTCGCGGCG
GCTGAATTACCGCTCGGATGACGAGCACACGTTTCTCAAAGCTTTAGGACTCCGATGA

Structures

Toxin

• AlphaFold DB: X2H9L8