Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/HicA-HicB |
| Location | 345531..346170 | Replicon | chromosome |
| Accession | NZ_CP091515 | ||
| Organism | Snodgrassella alvi wkB2 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | X2HE68 |
| Locus tag | LVJ87_RS01635 | Protein ID | WP_025330119.1 |
| Coordinates | 345531..345713 (+) | Length | 61 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | X2H602 |
| Locus tag | LVJ87_RS01640 | Protein ID | WP_025330118.1 |
| Coordinates | 345745..346170 (+) | Length | 142 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LVJ87_RS01615 (LVJ87_01615) | 341157..341960 | - | 804 | WP_025330123.1 | phage minor head protein | - |
| LVJ87_RS01620 (LVJ87_01620) | 341911..343464 | - | 1554 | WP_025330122.1 | DUF1073 domain-containing protein | - |
| LVJ87_RS01625 (LVJ87_01625) | 343461..344804 | - | 1344 | WP_025330121.1 | PBSX family phage terminase large subunit | - |
| LVJ87_RS01630 (LVJ87_01630) | 344797..345345 | - | 549 | WP_198209771.1 | terminase small subunit | - |
| LVJ87_RS01635 (LVJ87_01635) | 345531..345713 | + | 183 | WP_025330119.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| LVJ87_RS01640 (LVJ87_01640) | 345745..346170 | + | 426 | WP_025330118.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| LVJ87_RS01645 (LVJ87_01645) | 346167..346415 | + | 249 | WP_025330117.1 | helix-turn-helix transcriptional regulator | - |
| LVJ87_RS01650 (LVJ87_01650) | 346692..346865 | + | 174 | WP_025330116.1 | type II toxin-antitoxin system HicA family toxin | - |
| LVJ87_RS01655 (LVJ87_01655) | 346976..347458 | + | 483 | WP_237749812.1 | type II toxin-antitoxin system HicB family antitoxin | - |
| LVJ87_RS01660 (LVJ87_01660) | 347621..348121 | - | 501 | WP_038648687.1 | hypothetical protein | - |
| LVJ87_RS01665 (LVJ87_01665) | 348132..348425 | - | 294 | WP_025330113.1 | DUF1364 domain-containing protein | - |
| LVJ87_RS01670 (LVJ87_01670) | 348428..349027 | - | 600 | WP_025330112.1 | DUF1367 family protein | - |
| LVJ87_RS01675 (LVJ87_01675) | 349030..349377 | - | 348 | WP_025330111.1 | hypothetical protein | - |
| LVJ87_RS01680 (LVJ87_01680) | 349307..349660 | - | 354 | WP_025330110.1 | hypothetical protein | - |
| LVJ87_RS01685 (LVJ87_01685) | 349650..350165 | - | 516 | WP_025330109.1 | DNA N-6-adenine-methyltransferase | - |
| LVJ87_RS01690 (LVJ87_01690) | 350162..350419 | - | 258 | WP_144353315.1 | hypothetical protein | - |
| LVJ87_RS01695 (LVJ87_01695) | 350434..350853 | - | 420 | WP_237749811.1 | hypothetical protein | - |
| LVJ87_RS01700 (LVJ87_01700) | 350863..350928 | - | 66 | Protein_334 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 310324..370571 | 60247 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 61 a.a. Molecular weight: 6827.97 Da Isoelectric Point: 10.9086
>T233460 WP_025330119.1 NZ_CP091515:345531-345713 [Snodgrassella alvi wkB2]
MHSSKVIKRLLDDGWYEVAVRGSHHQFKHPEKSGRVTVPHPKKDLPLGTVKNIFKQAGLK
MHSSKVIKRLLDDGWYEVAVRGSHHQFKHPEKSGRVTVPHPKKDLPLGTVKNIFKQAGLK
Download Length: 183 bp
>T233460 NZ_HG938371:c1688915-1688499 [Burkholderia cenocepacia H111]
GTGTTTTTGATTGATACGAACGTCATCAGCGAAATCAGGAAGGGCAAGCGAACCAACCGCGGCGTGAGGGCGTTCTTCAG
GCAGGCCGAAGCGGACGCGAGCCCGCTTTACCTGTCCGTCGTGACGGTGGCCGAGCTGCGGCGCGGTGTCGACCTGATCC
GTCATCGCGGCGATCACAGCCAGGCGTCGGCGCTCGAGGCTTGGCTCACGATGATCCTGTCCGGCTATGCGCCGAACATC
CTGCCGGTCGATGTCGAAACCGGCCAGATGTGGGGGCATTTGCGCGTGCCCGATCCGACGCACGAACTCGACAAGCTGAT
CGCGGCCACCGCGTTGATCAACGATTTGACGGTCGTCACGCGCAACGTCGACGATTTCGCTCGCACCGGCGTCCGGTTGC
TGAATCCGTTCGAGTAA
GTGTTTTTGATTGATACGAACGTCATCAGCGAAATCAGGAAGGGCAAGCGAACCAACCGCGGCGTGAGGGCGTTCTTCAG
GCAGGCCGAAGCGGACGCGAGCCCGCTTTACCTGTCCGTCGTGACGGTGGCCGAGCTGCGGCGCGGTGTCGACCTGATCC
GTCATCGCGGCGATCACAGCCAGGCGTCGGCGCTCGAGGCTTGGCTCACGATGATCCTGTCCGGCTATGCGCCGAACATC
CTGCCGGTCGATGTCGAAACCGGCCAGATGTGGGGGCATTTGCGCGTGCCCGATCCGACGCACGAACTCGACAAGCTGAT
CGCGGCCACCGCGTTGATCAACGATTTGACGGTCGTCACGCGCAACGTCGACGATTTCGCTCGCACCGGCGTCCGGTTGC
TGAATCCGTTCGAGTAA
Antitoxin
Download Length: 142 a.a. Molecular weight: 15742.73 Da Isoelectric Point: 4.5106
>AT233460 WP_025330118.1 NZ_CP091515:345745-346170 [Snodgrassella alvi wkB2]
MFLYIAIHKDENTGYGVTVPSLPGCFSYGDTLEKAIEESKQAILFHIEGLLEDGIEPETNQPDLATLIDTPEYAGAQWFG
IEVNIDHLTLKPERFNVSWPKYLLNKVDTYVSLTHDTRSNFLAKAALERINSANQNAGIAK
MFLYIAIHKDENTGYGVTVPSLPGCFSYGDTLEKAIEESKQAILFHIEGLLEDGIEPETNQPDLATLIDTPEYAGAQWFG
IEVNIDHLTLKPERFNVSWPKYLLNKVDTYVSLTHDTRSNFLAKAALERINSANQNAGIAK
Download Length: 426 bp
>AT233460 NZ_HG938371:c1689138-1688902 [Burkholderia cenocepacia H111]
ATGGCAAATCTTCTGGTGCGTAACGTGGATGACACTCTCGTTCAAAGCCTGCGCGAGCAGGCTGCGGCCAACGGCAGGAG
CGCCGAGGCCGAACATCGAGCCATTCTGGCCGAAGCGCTCGGCCGGCCGAAGCGGCGCACATTCGCGCAAGTGCTGATGA
GCATGCCGGAGGTGGGTGAAGACGCGGATTTCCAACGTGTTCAGGATTCAGGCGAGGTCAGGCGTGTTTTTGATTGA
ATGGCAAATCTTCTGGTGCGTAACGTGGATGACACTCTCGTTCAAAGCCTGCGCGAGCAGGCTGCGGCCAACGGCAGGAG
CGCCGAGGCCGAACATCGAGCCATTCTGGCCGAAGCGCTCGGCCGGCCGAAGCGGCGCACATTCGCGCAAGTGCTGATGA
GCATGCCGGAGGTGGGTGAAGACGCGGATTTCCAACGTGTTCAGGATTCAGGCGAGGTCAGGCGTGTTTTTGATTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|