Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 1325292..1325878 Replicon chromosome
Accession NZ_CP091512
Organism Vitreoscilla stercoraria strain SAG 1488-6

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LVJ81_RS06525 Protein ID WP_019959540.1
Coordinates 1325624..1325878 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LVJ81_RS06520 Protein ID WP_019959539.1
Coordinates 1325292..1325627 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ81_RS06495 (LVJ81_06495) 1320486..1320773 + 288 WP_019959534.1 helix-turn-helix domain-containing protein -
LVJ81_RS06500 (LVJ81_06500) 1321192..1321656 + 465 WP_019959535.1 hypothetical protein -
LVJ81_RS06505 (LVJ81_06505) 1322083..1322277 - 195 WP_019959536.1 hypothetical protein -
LVJ81_RS06510 (LVJ81_06510) 1322706..1323260 + 555 WP_244802709.1 AraC family transcriptional regulator -
LVJ81_RS06515 (LVJ81_06515) 1323261..1324595 - 1335 WP_280520937.1 2-isopropylmalate synthase -
LVJ81_RS13130 1324618..1324935 - 318 WP_280520938.1 hypothetical protein -
LVJ81_RS06520 (LVJ81_06520) 1325292..1325627 - 336 WP_019959539.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LVJ81_RS06525 (LVJ81_06525) 1325624..1325878 - 255 WP_019959540.1 type II toxin-antitoxin system HicA family toxin Toxin
LVJ81_RS06530 (LVJ81_06530) 1325966..1326526 - 561 WP_026353726.1 recombinase family protein -
LVJ81_RS06535 (LVJ81_06535) 1326828..1327787 + 960 WP_019959482.1 type I-F CRISPR-associated endonuclease Cas1f -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 1292991..1420048 127057


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(23-75)

Antitoxin

Uncharacterised protein family HicB

(55-105)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9570.05 Da        Isoelectric Point: 10.6504

>T233458 WP_019959540.1 NZ_CP091512:c1325878-1325624 [Vitreoscilla stercoraria]
MKRKHQKTLELIFHRPVSGSIKWTEIEALFIELGANVQEREGSRIAVVLFGQVKVFHRPHPSPDTDKGAVASVRKWLDEN
GVRP

Download         Length: 255 bp

>T233458 NZ_HG938371:c798565-798248 [Burkholderia cenocepacia H111]
ATGCCCTACAGTCCTCCTGCATTCAGCATCCGGACCACCGACGTCTTCGACGCCTGGTTTGCCGGCCTGCCCGATCGCCT
CGCCAAACGCCGCATCCAGGCGCGCATCGACCGCCTGTCGATGGGCAATCCGGGCGACTGGAAATCCGCTGGCTCCCCCG
TCGTCGAAATGCGTATCGACCACGGCCCGGGCTATCGCGTCTATTACGTGAGGCGCGGAACGATATGGGTCATCCTGCTG
TGCGGCGGCGATAAATCGACGCAACAGGCCGACATCCGCGCCGCGCACGCAATGCTCGCGCACCTCGACATGGAGTGA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12199.91 Da        Isoelectric Point: 5.6459

>AT233458 WP_019959539.1 NZ_CP091512:c1325627-1325292 [Vitreoscilla stercoraria]
MINTMIINGYKAVIAYDSEIELFRGEFIGLNGGADFYAADVESLRREGAESLKVFLEVCKENGIEPKKQYSGRFNVRINP
KLHEDAMAAAIAQGISLNELVSRAIATAAHH

Download         Length: 336 bp

>AT233458 NZ_HG938371:c798244-797945 [Burkholderia cenocepacia H111]
ATGGACAAGATCAAGACCCGGCCGTGGGATTCGGCCGAACACCTGAAAACCGAAGACGACATGGCCGACTACTTCGACGC
ATGCCTGCAGGAGGCCGGCGACGATCCGGCCTTCATCGCGCATGCACTCGGCGTGATCGCCCGCGCACGCGGCATGTCGC
AGGTCGCGCGCGATGCGGGCCTGTCGCGCGAAGGGCTGTACAAGGCGCTGTCGCACGACGGCAATCCGAGCTTCGGCACG
ATCCTGAAAGTCATCAAGGCGCTTGGCCTGCAATTGCACGGCGCCAAGGCTGCCGTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References