Detailed information of TA system TA233456

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yoeB-relB/YoeB-RelB
• Location: 1984709..1985214
• Replicon: chromosome
• Accession: NZ_CP091509
• Organism: Neisseria dumasiana strain LMG 30012

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: LVJ88_RS09255
• Protein ID: WP_085419045.1
• Coordinates: 1984709..1984969 (-)
• Length: 87 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: LVJ88_RS09260
• Protein ID: WP_085360212.1
• Coordinates: 1984966..1985214 (-)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LVJ88_RS09225 (LVJ88_09225)	1980183..1981040	+	858	WP_085418982.1	LysR family transcriptional regulator	-
LVJ88_RS09230 (LVJ88_09230)	1981303..1981842	-	540	WP_085419050.1	hypothetical protein	-
LVJ88_RS09235 (LVJ88_09235)	1981833..1982303	-	471	WP_085419051.1	hypothetical protein	-
LVJ88_RS09240 (LVJ88_09240)	1982326..1983108	-	783	WP_085419052.1	N-6 DNA methylase	-
LVJ88_RS09245 (LVJ88_09245)	1983173..1983574	-	402	WP_244694150.1	phosphoglycerate kinase	-
LVJ88_RS09250 (LVJ88_09250)	1984195..1984605	+	411	WP_143773696.1	hypothetical protein	-
LVJ88_RS09255 (LVJ88_09255)	1984709..1984969	-	261	WP_085419045.1	Txe/YoeB family addiction module toxin	Toxin
LVJ88_RS09260 (LVJ88_09260)	1984966..1985214	-	249	WP_085360212.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
LVJ88_RS09265 (LVJ88_09265)	1985332..1985736	-	405	WP_085419044.1	type II toxin-antitoxin system VapC family toxin	-
LVJ88_RS09270 (LVJ88_09270)	1985733..1986014	-	282	WP_085419043.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	-
LVJ88_RS09275 (LVJ88_09275)	1986196..1986543	-	348	WP_054600261.1	type II toxin-antitoxin system PemK/MazF family toxin	-
LVJ88_RS09280 (LVJ88_09280)	1986540..1986782	-	243	WP_244694151.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	-
LVJ88_RS09285 (LVJ88_09285)	1987299..1988096	-	798	WP_244694152.1	hypothetical protein	-
LVJ88_RS09290 (LVJ88_09290)	1988113..1988322	-	210	WP_232005234.1	Cro/CI family transcriptional regulator	-
LVJ88_RS09295 (LVJ88_09295)	1988436..1989068	+	633	WP_085360218.1	S24 family peptidase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (4-75)

Sequences

Toxin

Protein

• Length: 87 a.a.
• Molecular weight: 10253.75 Da
• Isoelectric Point: 10.0297

>T233456 WP_085419045.1 NZ_CP091509:c1984969-1984709 [Neisseria dumasiana]
MKHRFTADAAEDLAYWVKHDGRKVERIKVLLEDIKINHPKGIGKPEPLRHQKSGLWSRRIDREHRLVYSVEEDTVTVYAC
RFHYGR

Nucleotide

• Length: 261 bp

>T233456 NZ_HG938370:1755478-1755777 [Burkholderia cenocepacia H111]
ATGGCGGTTAAAGGCAGACAACTTCGGCTGACCCCGTTGGCTGAATGCGATCTTGAAGACATTTGGCGCTATACCGCCGA
GCATTGGTCGCCTGAGCAGGCAGAGCACTATTACCGCGATCTGATTGGCACCATGGAAGCGCTGGCGCGCGGCAAAAAAG
CGGGGCGGATTTGCGTTGTTCGCGACGGATATTTTCGCTACCCCGCTGGTTCTCACGTTGTGTTCTATCGCGAAACGGAT
GAAACCATCGACGTCATCCGTGTCCTGCATCAACGGATGGACATCGAACGACATCTGTAG

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9220.29 Da
• Isoelectric Point: 4.3068

>AT233456 WP_085360212.1 NZ_CP091509:c1985214-1984966 [Neisseria dumasiana]
MDNVVSYTAAREDLANIMTKVCDDHVVTHITRRNGGNCVLMSEEEYNSIMETLYLFGNPTNAARLEHSLAQAERGEFVDV
EL

Nucleotide

• Length: 249 bp

>AT233456 NZ_HG938370:1755243-1755488 [Burkholderia cenocepacia H111]
ATGTCGCGAAACACATCCGTTTCCCTTGGCGATCACTTTGCAGAATTTGTCGATGCGCAGGTGCGATCGGGACGATATGG
TTCCGCAAGTGACGTCGTGCGAGCCGGGTTGCGGCTCCTCGAATCACACGAAACGCAAATGCGTGCATTGCAGGAAGCAT
TGAAGGCGGGTGAAGGGTCGGGGACGCCCAAGCCCTTCGACAGCGAGGCCTTCCTGGCCCGCATGCGGGCCACGCATGGC
GGTTAA