Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/VapC-VagC |
| Location | 1903771..1904415 | Replicon | chromosome |
| Accession | NZ_CP091509 | ||
| Organism | Neisseria dumasiana strain LMG 30012 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | - |
| Locus tag | LVJ88_RS08800 | Protein ID | WP_085418458.1 |
| Coordinates | 1904020..1904415 (+) | Length | 132 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | - |
| Locus tag | LVJ88_RS08795 | Protein ID | WP_085356725.1 |
| Coordinates | 1903771..1904016 (+) | Length | 82 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LVJ88_RS08775 (LVJ88_08775) | 1899081..1900247 | - | 1167 | WP_085418460.1 | ATP phosphoribosyltransferase regulatory subunit | - |
| LVJ88_RS08780 (LVJ88_08780) | 1900510..1901679 | - | 1170 | WP_085418459.1 | alpha-hydroxy acid oxidase | - |
| LVJ88_RS08785 (LVJ88_08785) | 1901969..1902412 | + | 444 | WP_054600297.1 | Fe-S cluster assembly transcriptional regulator IscR | - |
| LVJ88_RS08790 (LVJ88_08790) | 1902448..1903662 | + | 1215 | WP_054600298.1 | IscS subfamily cysteine desulfurase | - |
| LVJ88_RS08795 (LVJ88_08795) | 1903771..1904016 | + | 246 | WP_085356725.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | Antitoxin |
| LVJ88_RS08800 (LVJ88_08800) | 1904020..1904415 | + | 396 | WP_085418458.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| LVJ88_RS08805 (LVJ88_08805) | 1904542..1904928 | + | 387 | WP_085418457.1 | Fe-S cluster assembly scaffold IscU | - |
| LVJ88_RS08810 (LVJ88_08810) | 1904994..1905215 | + | 222 | Protein_1722 | TraR/DksA C4-type zinc finger protein | - |
| LVJ88_RS08815 (LVJ88_08815) | 1905577..1905813 | + | 237 | WP_085418456.1 | recombinase RecA | - |
| LVJ88_RS08820 (LVJ88_08820) | 1905954..1906274 | + | 321 | WP_054600303.1 | iron-sulfur cluster assembly protein IscA | - |
| LVJ88_RS08825 (LVJ88_08825) | 1906383..1906919 | + | 537 | WP_085356722.1 | inorganic diphosphatase | - |
| LVJ88_RS08830 (LVJ88_08830) | 1907170..1907523 | - | 354 | WP_085356721.1 | helix-turn-helix domain-containing protein | - |
| LVJ88_RS08835 (LVJ88_08835) | 1907719..1907955 | + | 237 | WP_085356720.1 | DUF896 domain-containing protein | - |
| LVJ88_RS08840 (LVJ88_08840) | 1908005..1908880 | + | 876 | WP_085418455.1 | pirin family protein | - |
| LVJ88_RS08845 (LVJ88_08845) | 1909171..1909317 | - | 147 | WP_082403052.1 | FeoB-associated Cys-rich membrane protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | vipB/tssC / vipA/tssB / hcp/tssD / luxS | 1887285..1983159 | 95874 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 132 a.a. Molecular weight: 14471.77 Da Isoelectric Point: 9.4213
>T233455 WP_085418458.1 NZ_CP091509:1904020-1904415 [Neisseria dumasiana]
MRYLLDTNIVSHILRRQPNVMARLQSVPMSDLYISAVTHAELMYGLAKKPDAAKLHRAVHELLLRIGVLPFDEQASTHYG
KFKAQAKQSGKNLASLDMMIAAHASAVSAVLVSNDAAFQQIADLSVEDWTK
MRYLLDTNIVSHILRRQPNVMARLQSVPMSDLYISAVTHAELMYGLAKKPDAAKLHRAVHELLLRIGVLPFDEQASTHYG
KFKAQAKQSGKNLASLDMMIAAHASAVSAVLVSNDAAFQQIADLSVEDWTK
Download Length: 396 bp
>T233455 NZ_HG938370:85551-85952 [Burkholderia cenocepacia H111]
ATGCCGCGCTTCATGCTCGACACCAACATGTGTATCTATCTGATGAAAAATCAGCCTGAGCAGGTCGCGAGACGGTTTGC
GCGGTGCTACACGGGCGACGTCGTCATGTCGGCGATCACCTATGCGGAGCTCGAGTACGGCCTGACCGCTTGTGCGAATC
CCGCGCGGGAGCGCCGCCATCTCGCCGCATTGATCGAGGATATTCCCGTCGCGCCTTTCGACGCGGCGGCCGCGCAAGCG
TATGGCCCGGTTCGCGAGGCCACCCGCGAGCGGAAGAAGGATCACCTCGACAAACTGATTGCCGCGCATGCGGTGTCGCT
CGATGTCGTCCTTGTCACCAACAACGAGCGCGATTTCGTCAGCTATCCGGGATTGCGACTGGAGAACTGGCTGAACGATT
AG
ATGCCGCGCTTCATGCTCGACACCAACATGTGTATCTATCTGATGAAAAATCAGCCTGAGCAGGTCGCGAGACGGTTTGC
GCGGTGCTACACGGGCGACGTCGTCATGTCGGCGATCACCTATGCGGAGCTCGAGTACGGCCTGACCGCTTGTGCGAATC
CCGCGCGGGAGCGCCGCCATCTCGCCGCATTGATCGAGGATATTCCCGTCGCGCCTTTCGACGCGGCGGCCGCGCAAGCG
TATGGCCCGGTTCGCGAGGCCACCCGCGAGCGGAAGAAGGATCACCTCGACAAACTGATTGCCGCGCATGCGGTGTCGCT
CGATGTCGTCCTTGTCACCAACAACGAGCGCGATTTCGTCAGCTATCCGGGATTGCGACTGGAGAACTGGCTGAACGATT
AG
Antitoxin
Download Length: 82 a.a. Molecular weight: 9251.10 Da Isoelectric Point: 4.1834
>AT233455 WP_085356725.1 NZ_CP091509:1903771-1904016 [Neisseria dumasiana]
MQTAKLFQNGRSQAVRLPAAFRFTGDEVYIRRDEATGDVILSQRPSDWQGFIAAASELDESDTIERDTSIQQRDPFADWQ
E
MQTAKLFQNGRSQAVRLPAAFRFTGDEVYIRRDEATGDVILSQRPSDWQGFIAAASELDESDTIERDTSIQQRDPFADWQ
E
Download Length: 246 bp
>AT233455 NZ_HG938370:85315-85551 [Burkholderia cenocepacia H111]
ATGCATACCACGAGGGTATTCAGGAACGGCAACTCGCAGGCCGTGCGAATTCCTGCGGACCTTGCCTATGAGCGCAGCGA
TATCGAACTGGAAATTGAGCGCGTCGGTGACGAAATCCGCATTCGGCCGATGCGGCGGCCTTTGACTCAGGTACTGGCGA
AGTTCGCGAAATTCGGGCCGGACTTCATGGCCGATGGGCGTGGCGACCACGAGCAGGCCGAACGCGAGGGTTTGTGA
ATGCATACCACGAGGGTATTCAGGAACGGCAACTCGCAGGCCGTGCGAATTCCTGCGGACCTTGCCTATGAGCGCAGCGA
TATCGAACTGGAAATTGAGCGCGTCGGTGACGAAATCCGCATTCGGCCGATGCGGCGGCCTTTGACTCAGGTACTGGCGA
AGTTCGCGAAATTCGGGCCGGACTTCATGGCCGATGGGCGTGGCGACCACGAGCAGGCCGAACGCGAGGGTTTGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|