Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1903771..1904415 Replicon chromosome
Accession NZ_CP091509
Organism Neisseria dumasiana strain LMG 30012

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LVJ88_RS08800 Protein ID WP_085418458.1
Coordinates 1904020..1904415 (+) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LVJ88_RS08795 Protein ID WP_085356725.1
Coordinates 1903771..1904016 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ88_RS08775 (LVJ88_08775) 1899081..1900247 - 1167 WP_085418460.1 ATP phosphoribosyltransferase regulatory subunit -
LVJ88_RS08780 (LVJ88_08780) 1900510..1901679 - 1170 WP_085418459.1 alpha-hydroxy acid oxidase -
LVJ88_RS08785 (LVJ88_08785) 1901969..1902412 + 444 WP_054600297.1 Fe-S cluster assembly transcriptional regulator IscR -
LVJ88_RS08790 (LVJ88_08790) 1902448..1903662 + 1215 WP_054600298.1 IscS subfamily cysteine desulfurase -
LVJ88_RS08795 (LVJ88_08795) 1903771..1904016 + 246 WP_085356725.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
LVJ88_RS08800 (LVJ88_08800) 1904020..1904415 + 396 WP_085418458.1 type II toxin-antitoxin system VapC family toxin Toxin
LVJ88_RS08805 (LVJ88_08805) 1904542..1904928 + 387 WP_085418457.1 Fe-S cluster assembly scaffold IscU -
LVJ88_RS08810 (LVJ88_08810) 1904994..1905215 + 222 Protein_1722 TraR/DksA C4-type zinc finger protein -
LVJ88_RS08815 (LVJ88_08815) 1905577..1905813 + 237 WP_085418456.1 recombinase RecA -
LVJ88_RS08820 (LVJ88_08820) 1905954..1906274 + 321 WP_054600303.1 iron-sulfur cluster assembly protein IscA -
LVJ88_RS08825 (LVJ88_08825) 1906383..1906919 + 537 WP_085356722.1 inorganic diphosphatase -
LVJ88_RS08830 (LVJ88_08830) 1907170..1907523 - 354 WP_085356721.1 helix-turn-helix domain-containing protein -
LVJ88_RS08835 (LVJ88_08835) 1907719..1907955 + 237 WP_085356720.1 DUF896 domain-containing protein -
LVJ88_RS08840 (LVJ88_08840) 1908005..1908880 + 876 WP_085418455.1 pirin family protein -
LVJ88_RS08845 (LVJ88_08845) 1909171..1909317 - 147 WP_082403052.1 FeoB-associated Cys-rich membrane protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - vipB/tssC / vipA/tssB / hcp/tssD / luxS 1887285..1983159 95874


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-123)

Antitoxin

SpoVT-AbrB domain

(7-38)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14471.77 Da        Isoelectric Point: 9.4213

>T233455 WP_085418458.1 NZ_CP091509:1904020-1904415 [Neisseria dumasiana]
MRYLLDTNIVSHILRRQPNVMARLQSVPMSDLYISAVTHAELMYGLAKKPDAAKLHRAVHELLLRIGVLPFDEQASTHYG
KFKAQAKQSGKNLASLDMMIAAHASAVSAVLVSNDAAFQQIADLSVEDWTK

Download         Length: 396 bp

>T233455 NZ_HG938370:85551-85952 [Burkholderia cenocepacia H111]
ATGCCGCGCTTCATGCTCGACACCAACATGTGTATCTATCTGATGAAAAATCAGCCTGAGCAGGTCGCGAGACGGTTTGC
GCGGTGCTACACGGGCGACGTCGTCATGTCGGCGATCACCTATGCGGAGCTCGAGTACGGCCTGACCGCTTGTGCGAATC
CCGCGCGGGAGCGCCGCCATCTCGCCGCATTGATCGAGGATATTCCCGTCGCGCCTTTCGACGCGGCGGCCGCGCAAGCG
TATGGCCCGGTTCGCGAGGCCACCCGCGAGCGGAAGAAGGATCACCTCGACAAACTGATTGCCGCGCATGCGGTGTCGCT
CGATGTCGTCCTTGTCACCAACAACGAGCGCGATTTCGTCAGCTATCCGGGATTGCGACTGGAGAACTGGCTGAACGATT
AG

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9251.10 Da        Isoelectric Point: 4.1834

>AT233455 WP_085356725.1 NZ_CP091509:1903771-1904016 [Neisseria dumasiana]
MQTAKLFQNGRSQAVRLPAAFRFTGDEVYIRRDEATGDVILSQRPSDWQGFIAAASELDESDTIERDTSIQQRDPFADWQ
E

Download         Length: 246 bp

>AT233455 NZ_HG938370:85315-85551 [Burkholderia cenocepacia H111]
ATGCATACCACGAGGGTATTCAGGAACGGCAACTCGCAGGCCGTGCGAATTCCTGCGGACCTTGCCTATGAGCGCAGCGA
TATCGAACTGGAAATTGAGCGCGTCGGTGACGAAATCCGCATTCGGCCGATGCGGCGGCCTTTGACTCAGGTACTGGCGA
AGTTCGCGAAATTCGGGCCGGACTTCATGGCCGATGGGCGTGGCGACCACGAGCAGGCCGAACGCGAGGGTTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References