Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 1588132..1588718 Replicon chromosome
Accession NZ_CP091509
Organism Neisseria dumasiana strain LMG 30012

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LVJ88_RS07225 Protein ID WP_085417968.1
Coordinates 1588132..1588386 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LVJ88_RS07230 Protein ID WP_085360615.1
Coordinates 1588383..1588718 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ88_RS07215 (LVJ88_07215) 1583305..1586139 + 2835 WP_085417970.1 excinuclease ABC subunit UvrA -
LVJ88_RS07220 (LVJ88_07220) 1586416..1587831 + 1416 WP_085417969.1 Fic family protein -
LVJ88_RS07225 (LVJ88_07225) 1588132..1588386 + 255 WP_085417968.1 type II toxin-antitoxin system HicA family toxin Toxin
LVJ88_RS07230 (LVJ88_07230) 1588383..1588718 + 336 WP_085360615.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LVJ88_RS07235 (LVJ88_07235) 1588832..1589608 - 777 WP_085417967.1 ferredoxin--NADP reductase -
LVJ88_RS07240 (LVJ88_07240) 1589762..1590277 + 516 WP_085357030.1 signal peptidase II -
LVJ88_RS07245 (LVJ88_07245) 1590303..1591241 + 939 WP_054598759.1 4-hydroxy-3-methylbut-2-enyl diphosphate reductase -
LVJ88_RS07250 (LVJ88_07250) 1591698..1592204 - 507 WP_085417966.1 hemerythrin domain-containing protein -
LVJ88_RS07255 (LVJ88_07255) 1592366..1593145 + 780 WP_054598757.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(23-75)

Antitoxin

Uncharacterised protein family HicB

(55-105)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9467.91 Da        Isoelectric Point: 10.5624

>T233454 WP_085417968.1 NZ_CP091509:1588132-1588386 [Neisseria dumasiana]
MKKKHQRTFALIFNRPVSGSIKWGDIEALFTELGAEIQEREGSRVAVILFGQVKVFHRPHPSPDTDKGAVASVRKWLEEN
GVKP

Download         Length: 255 bp

>T233454 NZ_HG938356:c672994-672608 [Neorhizobium galegae bv. officinalis bv. officinalis str. HAMBI]
ATGATCGTCGACACTTCGGCGCTGGTCGCAATTCTTTATCGTGAGCCCGAGGCGGCAAGGTTTGTTAAGGCCATCCATGA
CGTCGAGCTCACGCGGATCAGCGTAGCGAATTACGTGGAGTTGTCGATGGTGGTGGAAGGCCAGCTCGGCCCTGATGGTA
TGCGCCAGGCGGAGGCTTTCCTCCGGCGCGCCGGCATCATCGTCGAGCCTGTCACTCTTGATCACGGCGAACTGGCCCGA
CAAGCTTTTCCAGATTTCGGTAAAGGCCGTCACAAGGCCGGTCTCAACTTCGGCGACTGCTTTGCTTATGCTCTAGCGAA
AGCGACTGGCGAACCGCTGCTGTTCAAGGGTAACGACTTCTCTCAAACCGATGTCCAGGCGGCGTAA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12031.45 Da        Isoelectric Point: 5.5571

>AT233454 WP_085360615.1 NZ_CP091509:1588383-1588718 [Neisseria dumasiana]
MNNVMEINGHKAIIQYDPETELLRGEFIGLNGGADFYADNVADLHKEGAASLAVFLDVCKEKGIEPYKRYSGRFNVRVSP
ETHAAAAAAAAAQNISLNEWVNRAISQSAHA

Download         Length: 336 bp

>AT233454 NZ_HG938356:c673239-672991 [Neorhizobium galegae bv. officinalis bv. officinalis str. HAMBI]
ATGAGCCTCAGCATCAAGGATCCGGAAGCCCATCGCCTGGCACAGGCGATCTCCCACGCCACGGGAGAAAGCATGACCCG
TGTCGTCACCGAGGCGTTGCGTGAGCGTTTTGCCAAGATCGAACGCCGAAAAGGCCGGGCCAGCGTCGAGGAGCTTCTCG
CGATCGCAGATCGCGCTGCGGCGAACGTCAAACGCCCCTATGTCGATCATGCTGATTTCCTTTATGACGAGAACGGCCTA
CCAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References