Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB(antitoxin)
Location 2033052..2033698 Replicon chromosome
Accession NZ_CP091508
Organism Uruburuella testudinis strain CCUG 63373m

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LVJ83_RS09340 Protein ID WP_123805061.1
Coordinates 2033052..2033234 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LVJ83_RS09345 Protein ID WP_244784239.1
Coordinates 2033279..2033698 (+) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ83_RS09315 (LVJ83_09315) 2029635..2030078 + 444 WP_244784236.1 Arm DNA-binding domain-containing protein -
LVJ83_RS09320 (LVJ83_09320) 2030023..2030691 + 669 WP_244784237.1 tyrosine-type recombinase/integrase -
LVJ83_RS09325 (LVJ83_09325) 2031121..2031336 + 216 WP_244784238.1 hypothetical protein -
LVJ83_RS09330 (LVJ83_09330) 2031568..2031834 + 267 Protein_1836 transposase -
LVJ83_RS09335 (LVJ83_09335) 2032006..2032922 + 917 Protein_1837 phage antirepressor N-terminal domain-containing protein -
LVJ83_RS09340 (LVJ83_09340) 2033052..2033234 + 183 WP_123805061.1 type II toxin-antitoxin system HicA family toxin Toxin
LVJ83_RS09345 (LVJ83_09345) 2033279..2033698 + 420 WP_244784239.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LVJ83_RS09350 (LVJ83_09350) 2033935..2034351 - 417 WP_244784240.1 phage virion morphogenesis protein -
LVJ83_RS09355 (LVJ83_09355) 2034457..2035746 - 1290 WP_244784241.1 phage minor head protein -
LVJ83_RS09360 (LVJ83_09360) 2035733..2037301 - 1569 WP_244784242.1 DUF935 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2022521..2047420 24899


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-126)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6830.96 Da        Isoelectric Point: 11.0962

>T233452 WP_123805061.1 NZ_CP091508:2033052-2033234 [Uruburuella testudinis]
MKYSEFRKWLLSQGVEFTTQKRGSHQLIRLGNKTSVFPNHGSKEIGTGLVNKIKKDLGLK

Download         Length: 183 bp

>T233452 NZ_HG938356:c281537-281115 [Neorhizobium galegae bv. officinalis bv. officinalis str. HAMBI]
GTGAAACTGCTCATCGACACCAACGTTCTGTCTGAAGTAACAAAGCCCCATCCCGACGCACGCGTTTTAGAATGGCTTGG
CGGGCTCGACGAAGACCGCGCCTATATCAGCGTCATATCAATCGCAGAAATCCGCCGAGGCGTCGCTTTGATGGATAGCG
GGCGAAAACGCGACACTCTGGCGGAATGGCTTTCGCATGACCTGCCGCAGCGTTTCGAGGGGCGAGTGATTCCGGTGGAA
GAGCCTGTTGCCCTGTCGTGGGGCGATCTCATGGCGCTTGCCAAGCAGAGTGGCCGCGGACTGGCTTCAATGGACGGATT
AATCGCCGCCACCGCGATAGCACACCATCTCACCCTCGCGACGCGCAACACCAAAGATTTTGAAGGTTTCGGTATTGATA
TGATCAATCCGTGGAACGGCTAG

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15408.68 Da        Isoelectric Point: 4.6562

>AT233452 WP_244784239.1 NZ_CP091508:2033279-2033698 [Uruburuella testudinis]
MLAYPYKLTPDDNGTFLVTFPDIPEATAVGEDLESAKIEALDGLLCALDGYFEDRRAIPLPGSYSDTQDTVSLPALETAK
VLLLNEMVSQGVKKAEMARRLEVHMPQVDRLLDLRHNTKIDFMEKAASKLGKHLNISFS

Download         Length: 420 bp

>AT233452 NZ_HG938356:c281800-281534 [Neorhizobium galegae bv. officinalis bv. officinalis str. HAMBI]
ATGCGGCCATCAGCACACGATGATAGGATCTGGACGGTCGCCGGCGCCAAAGCAAAACTCTCCGAGGTCATCGAGCGAGC
ACAATCAGCGCCCCAGACAATCACGCGGAACGGAAAACCAAGCGTGGTTGTCGTTTCGGCGGAAGAATGGCAGCGGAAAA
TAGCACGCAAAGGATCACTTGCAGAATTCCTCATGGACTCGCCGCTCCGCGGTGCCGGCTTGGATCTGGATCGTGAACGC
GATGAGCCACGTGATCTGCCGCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References