Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 199937..200463 | Replicon | plasmid unnamed1 |
| Accession | NZ_CP091497 | ||
| Organism | Enterobacter cloacae complex sp. ECL404 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | L3071_RS23885 | Protein ID | WP_000323025.1 |
| Coordinates | 199937..200224 (-) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | L3071_RS23890 | Protein ID | WP_000534858.1 |
| Coordinates | 200224..200463 (-) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| L3071_RS23850 (L3071_23850) | 195507..195683 | - | 177 | WP_001371930.1 | hypothetical protein | - |
| L3071_RS23855 (L3071_23855) | 196194..197138 | + | 945 | WP_000778029.1 | DUF5417 domain-containing protein | - |
| L3071_RS23860 (L3071_23860) | 197234..197836 | + | 603 | WP_012695474.1 | hypothetical protein | - |
| L3071_RS23865 (L3071_23865) | 197896..198246 | + | 351 | WP_000743059.1 | hypothetical protein | - |
| L3071_RS23870 (L3071_23870) | 198293..198496 | + | 204 | WP_001015183.1 | hypothetical protein | - |
| L3071_RS23875 (L3071_23875) | 198778..199098 | + | 321 | WP_000332796.1 | hypothetical protein | - |
| L3071_RS23880 (L3071_23880) | 199711..199836 | - | 126 | WP_229020258.1 | DUF5431 family protein | - |
| L3071_RS23885 (L3071_23885) | 199937..200224 | - | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| L3071_RS23890 (L3071_23890) | 200224..200463 | - | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| L3071_RS23895 (L3071_23895) | 200488..200592 | + | 105 | Protein_219 | hypothetical protein | - |
| L3071_RS23900 (L3071_23900) | 200726..201649 | - | 924 | WP_000167917.1 | cation diffusion facilitator family transporter | - |
| L3071_RS23905 (L3071_23905) | 201849..202421 | - | 573 | WP_001515348.1 | cytochrome b/b6 domain-containing protein | - |
| L3071_RS23910 (L3071_23910) | 202897..204135 | - | 1239 | WP_000219087.1 | IS110-like element ISEsa2 family transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | blaTEM-1B / dfrA19 / aph(3'')-Ib / aph(6)-Id / mcr-9 / aph(3')-Ia / tet(D) / catA2 / blaSHV-12 / sul1 / blaDHA-1 / qnrB4 / qacE / ere(A) / aac(6')-IIc | - | 1..319000 | 319000 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T233446 WP_000323025.1 NZ_CP091497:c200224-199937 [Enterobacter cloacae complex sp. ECL404]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T233446 NZ_HG938355:c4495698-4495402 [Neorhizobium galegae bv. officinalis bv. officinalis str. HAMBI]
GTGTTCGAGCTCAAGCAGACGGAAACGTTTCTGAAATGGCGCACGCGTCTGAAGGACGAGCGTGCTCGCGCATTGATAGC
CTCGCGTCTGGACCGGCTCGCTTTCGGGCATGCCGGAGATGTGGCCCCCGTCGGCGAAGGTGTCAGCGAACTGCGCATCC
ATCATGGGCCGGGTTACCGCGTCTATTTTCAGCAGCGCGGTGACATCCTAATCGTTCTTCTGTGCGGTGGCGACAAAAGC
AGCCAGGCAAAGGACATCAAGGCTGCAAAGCGACTGGCGATGGAATGGAGTGAGTGA
GTGTTCGAGCTCAAGCAGACGGAAACGTTTCTGAAATGGCGCACGCGTCTGAAGGACGAGCGTGCTCGCGCATTGATAGC
CTCGCGTCTGGACCGGCTCGCTTTCGGGCATGCCGGAGATGTGGCCCCCGTCGGCGAAGGTGTCAGCGAACTGCGCATCC
ATCATGGGCCGGGTTACCGCGTCTATTTTCAGCAGCGCGGTGACATCCTAATCGTTCTTCTGTGCGGTGGCGACAAAAGC
AGCCAGGCAAAGGACATCAAGGCTGCAAAGCGACTGGCGATGGAATGGAGTGAGTGA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT233446 WP_000534858.1 NZ_CP091497:c200463-200224 [Enterobacter cloacae complex sp. ECL404]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT233446 NZ_HG938355:c4495402-4495115 [Neorhizobium galegae bv. officinalis bv. officinalis str. HAMBI]
ATGGCTGAAAAACTAACCGTTTACGATCCAGCCGAAGACCTGGGCTCCGATCAGGCGATTGCGGCATTTATGGCCGAAGC
TTTCGAGACGGAGGACGCGGCCTACATTGCGCATGCCTTAGGGGTGGTTGCCCGTGCCAAGGGGATGATGCAGATTGCCA
AAGACACCGGTCTTTCCCGAGAGCAGCTCTATCGTTCCTTTAGCGCCACCGGAAACCCGACGCTCAAGACGACGATTGCA
GTGATGAAATCGTTGGGGATCGAGTTGACCGCCAAGGCCCATTCCTGA
ATGGCTGAAAAACTAACCGTTTACGATCCAGCCGAAGACCTGGGCTCCGATCAGGCGATTGCGGCATTTATGGCCGAAGC
TTTCGAGACGGAGGACGCGGCCTACATTGCGCATGCCTTAGGGGTGGTTGCCCGTGCCAAGGGGATGATGCAGATTGCCA
AAGACACCGGTCTTTCCCGAGAGCAGCTCTATCGTTCCTTTAGCGCCACCGGAAACCCGACGCTCAAGACGACGATTGCA
GTGATGAAATCGTTGGGGATCGAGTTGACCGCCAAGGCCCATTCCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|