Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 354329..354855 | Replicon | plasmid unnamed1 |
| Accession | NZ_CP091493 | ||
| Organism | Enterobacter cloacae complex sp. ECL405 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | L3070_RS25460 | Protein ID | WP_000323025.1 |
| Coordinates | 354329..354616 (-) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | L3070_RS25465 | Protein ID | WP_000534858.1 |
| Coordinates | 354616..354855 (-) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| L3070_RS25425 (L3070_25425) | 349904..350080 | - | 177 | WP_001371930.1 | hypothetical protein | - |
| L3070_RS25430 (L3070_25430) | 350591..351535 | + | 945 | WP_000778029.1 | DUF5417 domain-containing protein | - |
| L3070_RS25435 (L3070_25435) | 351631..352233 | + | 603 | WP_012695474.1 | hypothetical protein | - |
| L3070_RS25440 (L3070_25440) | 352293..352643 | + | 351 | WP_000743059.1 | hypothetical protein | - |
| L3070_RS25445 (L3070_25445) | 352690..352893 | + | 204 | WP_001015183.1 | hypothetical protein | - |
| L3070_RS25450 (L3070_25450) | 353175..353495 | + | 321 | WP_000332796.1 | hypothetical protein | - |
| L3070_RS25455 (L3070_25455) | 354103..354228 | - | 126 | WP_229020258.1 | DUF5431 family protein | - |
| L3070_RS25460 (L3070_25460) | 354329..354616 | - | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| L3070_RS25465 (L3070_25465) | 354616..354855 | - | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| L3070_RS25470 (L3070_25470) | 354880..354984 | + | 105 | Protein_397 | hypothetical protein | - |
| L3070_RS25475 (L3070_25475) | 355118..356041 | - | 924 | WP_000167917.1 | cation diffusion facilitator family transporter | - |
| L3070_RS25480 (L3070_25480) | 356241..356813 | - | 573 | WP_001515348.1 | cytochrome b/b6 domain-containing protein | - |
| L3070_RS25485 (L3070_25485) | 357288..358524 | - | 1237 | Protein_400 | IS110 family transposase | - |
| L3070_RS25490 (L3070_25490) | 358945..359094 | - | 150 | WP_141119139.1 | hypothetical protein | - |
| L3070_RS25495 (L3070_25495) | 359052..359486 | - | 435 | WP_236904372.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | blaSHV-12 / mph(A) / blaTEM-1B / dfrA19 / blaIMP-26 / qacE / sul1 / mcr-9 | - | 1..362923 | 362923 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T233433 WP_000323025.1 NZ_CP091493:c354616-354329 [Enterobacter cloacae complex sp. ECL405]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T233433 NZ_HG938355:659162-659461 [Neorhizobium galegae bv. officinalis bv. officinalis str. HAMBI]
ATGGCCGCTAAGGGCCGGGACTATAAGCTTTCACCGCTCGCGGAAGAGGATCTTGAGGATATTTGGGGTTACACGGTCGA
AACGTGGTCTTGGGAACAGGCCGAGCGCTACCACGATGAACTGATCTCAACTCTGGAAGGATTGGCGGCAGGGCGGAAAC
TCGGTCGGCCGGTTGATATTCGGCAAGGATATTTCAAATATTCCGTCGGTGCGCATTGTGTTTTCTATCGGTTTTCCGAA
AGCGCGATCGATATTATCCGCATCCTCCATCAGAAGATGGACGTCAGCCGACACCTCTAG
ATGGCCGCTAAGGGCCGGGACTATAAGCTTTCACCGCTCGCGGAAGAGGATCTTGAGGATATTTGGGGTTACACGGTCGA
AACGTGGTCTTGGGAACAGGCCGAGCGCTACCACGATGAACTGATCTCAACTCTGGAAGGATTGGCGGCAGGGCGGAAAC
TCGGTCGGCCGGTTGATATTCGGCAAGGATATTTCAAATATTCCGTCGGTGCGCATTGTGTTTTCTATCGGTTTTCCGAA
AGCGCGATCGATATTATCCGCATCCTCCATCAGAAGATGGACGTCAGCCGACACCTCTAG
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT233433 WP_000534858.1 NZ_CP091493:c354855-354616 [Enterobacter cloacae complex sp. ECL405]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT233433 NZ_HG938355:658927-659172 [Neorhizobium galegae bv. officinalis bv. officinalis str. HAMBI]
ATGGCTCGAAATACATCCATCTCACTTGGCGATCATTTCGCCAGCTTCATCGACACGCAGGTCGAAAGCGGCCGTTATGG
TTCGGCAAGCGATGTCGTCAGGGCAGGCCTGCGTCTGCTTGAAGAACATGAGGCCCGGGTCAAAGCTTTACAGGACGCTC
TGATTGCCGGTGAAGAGTCTGGCCCGCCACAACCCTTTGATAATCAGGCATTTCTGAAACGGATGCGAGCGCGTCATGGC
CGCTAA
ATGGCTCGAAATACATCCATCTCACTTGGCGATCATTTCGCCAGCTTCATCGACACGCAGGTCGAAAGCGGCCGTTATGG
TTCGGCAAGCGATGTCGTCAGGGCAGGCCTGCGTCTGCTTGAAGAACATGAGGCCCGGGTCAAAGCTTTACAGGACGCTC
TGATTGCCGGTGAAGAGTCTGGCCCGCCACAACCCTTTGATAATCAGGCATTTCTGAAACGGATGCGAGCGCGTCATGGC
CGCTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|