Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hipBA/HipA-HipB |
| Location | 232569..234192 | Replicon | plasmid unnamed1 |
| Accession | NZ_CP091493 | ||
| Organism | Enterobacter cloacae complex sp. ECL405 | ||
Toxin (Protein)
| Gene name | hipA | Uniprot ID | C1IUI3 |
| Locus tag | L3070_RS24730 | Protein ID | WP_000088044.1 |
| Coordinates | 232867..234192 (+) | Length | 442 a.a. |
Antitoxin (Protein)
| Gene name | hipB | Uniprot ID | A0A6M3PBR7 |
| Locus tag | L3070_RS24725 | Protein ID | WP_012477377.1 |
| Coordinates | 232569..232862 (+) | Length | 98 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| L3070_RS24700 (L3070_24700) | 227706..228410 | - | 705 | WP_001067855.1 | IS6-like element IS26 family transposase | - |
| L3070_RS24705 (L3070_24705) | 228401..228760 | + | 360 | WP_063945302.1 | hypothetical protein | - |
| L3070_RS24710 (L3070_24710) | 229419..230075 | + | 657 | WP_000462754.1 | trypsin-like serine protease | - |
| L3070_RS24715 (L3070_24715) | 230278..230775 | + | 498 | WP_000340139.1 | membrane protein | - |
| L3070_RS24720 (L3070_24720) | 230780..232168 | + | 1389 | WP_012695445.1 | hypothetical protein | - |
| L3070_RS24725 (L3070_24725) | 232569..232862 | + | 294 | WP_012477377.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| L3070_RS24730 (L3070_24730) | 232867..234192 | + | 1326 | WP_000088044.1 | type II toxin-antitoxin system HipA family toxin | Toxin |
| L3070_RS24735 (L3070_24735) | 234253..234459 | + | 207 | WP_000134171.1 | hypothetical protein | - |
| L3070_RS24740 (L3070_24740) | 234560..234970 | + | 411 | WP_000985909.1 | hypothetical protein | - |
| L3070_RS24745 (L3070_24745) | 234983..235507 | + | 525 | WP_001805097.1 | hypothetical protein | - |
| L3070_RS24750 (L3070_24750) | 235689..236303 | - | 615 | Protein_253 | IS110-like element IS4321 family transposase | - |
| L3070_RS24755 (L3070_24755) | 236359..237327 | - | 969 | WP_072202995.1 | IS5 family transposase | - |
| L3070_RS24760 (L3070_24760) | 237360..237758 | - | 399 | Protein_255 | IS110 family transposase | - |
| L3070_RS24765 (L3070_24765) | 237849..238283 | - | 435 | WP_000405672.1 | Cd(II)/Pb(II)-responsive transcriptional regulator | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | blaSHV-12 / mph(A) / blaTEM-1B / dfrA19 / blaIMP-26 / qacE / sul1 / mcr-9 | - | 1..362923 | 362923 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 442 a.a. Molecular weight: 50333.32 Da Isoelectric Point: 6.5044
>T233432 WP_000088044.1 NZ_CP091493:232867-234192 [Enterobacter cloacae complex sp. ECL405]
MSRKQQRLAIWMNGIKVGYWEKSKGVDSLQYLPDWSADEQGRPLSLSLPFTPGNQVWRGNVVRDYFDNLLPDSEGIRRRL
AMRYKADSLEPFDLLTELGKDCVGAIQLLHDGDEPTDLYSVKYHPLTESEIAATLRNTTETLLPGRPEDNDDLRLSIAGA
QEKTALLWHEDRWCMPEGNTPTTHIFKLPLGLVGNMKADMRSSVENEWLCSVLLEQYGLPVARTQIAHFEDQKALVVERF
DRKWSGNGQWIIRLPQEDMCQALGISPLRKYQADGGPGISEIMEVLSNSDRAERDKAQFFMTQIVFWMMAATDGHAKNFS
ISIGPQGRYHLTPLYDVLSAWPVIGHGNNQISWQKCKLAMAVRGSSNYYQIYRIQRRHWIRHGEITGLSKQQTEAMIEEI
IARTPGVIERVSGLLPDQFPQQLAESIFDGMRQQCRRLAEK
MSRKQQRLAIWMNGIKVGYWEKSKGVDSLQYLPDWSADEQGRPLSLSLPFTPGNQVWRGNVVRDYFDNLLPDSEGIRRRL
AMRYKADSLEPFDLLTELGKDCVGAIQLLHDGDEPTDLYSVKYHPLTESEIAATLRNTTETLLPGRPEDNDDLRLSIAGA
QEKTALLWHEDRWCMPEGNTPTTHIFKLPLGLVGNMKADMRSSVENEWLCSVLLEQYGLPVARTQIAHFEDQKALVVERF
DRKWSGNGQWIIRLPQEDMCQALGISPLRKYQADGGPGISEIMEVLSNSDRAERDKAQFFMTQIVFWMMAATDGHAKNFS
ISIGPQGRYHLTPLYDVLSAWPVIGHGNNQISWQKCKLAMAVRGSSNYYQIYRIQRRHWIRHGEITGLSKQQTEAMIEEI
IARTPGVIERVSGLLPDQFPQQLAESIFDGMRQQCRRLAEK
Download Length: 1326 bp
>T233432 NZ_HG938355:c584508-584260 [Neorhizobium galegae bv. officinalis bv. officinalis str. HAMBI]
TTGAAGATCATTTGGGACGAGACGAAGCGAATTGTGAACCTCGAGAAGCATGGTCTCGATTTCGCTGATCTTTATTTCGA
ATTCTTCGCGACGGCGGTGACCACGCCCGCCAGAAAGGCGAGGTCGAAAGCTGTCGGTCGCCTGAAGGATGGAACGATTG
TCGTAATATTCCTGACGCTTGGCTCGGAAGCAATCTCGGTCATTTCGATGCGCCCTGCCCGAAAAGATGAGAGGAGCATG
GTCGAATGA
TTGAAGATCATTTGGGACGAGACGAAGCGAATTGTGAACCTCGAGAAGCATGGTCTCGATTTCGCTGATCTTTATTTCGA
ATTCTTCGCGACGGCGGTGACCACGCCCGCCAGAAAGGCGAGGTCGAAAGCTGTCGGTCGCCTGAAGGATGGAACGATTG
TCGTAATATTCCTGACGCTTGGCTCGGAAGCAATCTCGGTCATTTCGATGCGCCCTGCCCGAAAAGATGAGAGGAGCATG
GTCGAATGA
Antitoxin
Download Length: 98 a.a. Molecular weight: 10860.30 Da Isoelectric Point: 10.3134
>AT233432 WP_012477377.1 NZ_CP091493:232569-232862 [Enterobacter cloacae complex sp. ECL405]
INNDYPLNTLNQLRPLLIGFRKANGLTQKDLSERLGVTQQTYSRLEANPASASIERLFKVFSILGVKISFSSTTASSEGK
QTEEMLKSNSPARQEKW
INNDYPLNTLNQLRPLLIGFRKANGLTQKDLSERLGVTQQTYSRLEANPASASIERLFKVFSILGVKISFSSTTASSEGK
QTEEMLKSNSPARQEKW
Download Length: 294 bp
>AT233432 NZ_HG938355:c584263-583949 [Neorhizobium galegae bv. officinalis bv. officinalis str. HAMBI]
ATGAATATCAAGCACGAAAAACAGAAAGAATTTCGCCCTGGTCGCGGATACACCAAAGAGGACTGGGACGCGGTCGACAG
TCCACCACTGACTGCTGAAGAGATGGCGAGCATGCGCCCGTTCCGGGAAGTGTTTCCCGAAATGGCCGCAAAAATGGAAC
AGGCGATCGCCGCTCGCGGCCGGCCGAAGGTCGAGGCGCCGAAGGTGGCCGTCACGCTGAGGCTCGACCCGGACGTGCTC
GAAAAATACAAGGCGTCAGGCAAAGACTGGCGAGCCAAAATGGCCGAGGAACTGCGCAAGGCAGCCGGCCTCTGA
ATGAATATCAAGCACGAAAAACAGAAAGAATTTCGCCCTGGTCGCGGATACACCAAAGAGGACTGGGACGCGGTCGACAG
TCCACCACTGACTGCTGAAGAGATGGCGAGCATGCGCCCGTTCCGGGAAGTGTTTCCCGAAATGGCCGCAAAAATGGAAC
AGGCGATCGCCGCTCGCGGCCGGCCGAAGGTCGAGGCGCCGAAGGTGGCCGTCACGCTGAGGCTCGACCCGGACGTGCTC
GAAAAATACAAGGCGTCAGGCAAAGACTGGCGAGCCAAAATGGCCGAGGAACTGCGCAAGGCAGCCGGCCTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2S1XXW1 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A6M3PBR7 |